Figure 1

Graphical representation of the cell and peptide targets of Botulinum neurotoxin. 1(A) is a representation of the Synaptic cleft where BoNT enters the eukaryotic nerve cell. 1(B) displays the position on the synaptobrevin-2 (VAMP-2) protein where BoNT/G cleaves, stopping the synaptic vesicle from releasing acetylcholine, inhibiting nerve impulse and causing muscle paralysis. In a healthy cell, synaptobrevin-2 on the synaptic vesicle must interact with syntaxin and synaptosomal-associated protein-25 (SNAP-25) on the neuronal membrane for fusion to occur. Fusion allows the nerve impulse to be delivered across the synaptic junction.