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Table 2 MIC values and summary of induction kinetics characteristics of different antibiotics

From: Induction kinetics of the Staphylococcus aureus cell wall stress stimulon in response to different cell wall active antibiotics

Antibiotic MICa Fold MIC decrease in BB255ΔVraRb Lag before inductionc Maximum inductiond Time point of maximum inductione Concentration dependencef OD/CFU/ml as % of controlg
Fosfomycin 0.5 2x 30 high 120 high (29.5) 47/10
D-Cycloserine 12 none 10 medium 60 high (25.5) 56/36
Bacitracin 32 10x none medium 60 low (1.5) 26/9
Tunicamycin 8 4x 10 high 120 medium (3.0) 38/9
Flavomycin 4 16x none high 60 low (1.6) 41/25
Vancomycin 1.3 2x none low 120 medium (12.6) 100/100
Oxacillin 0.2 none none high 120 high (19.1) 74/20
Daptomycin 0.25 2x none low 120 medium (14.1) 85/75
Lysostaphin 0.065 2x none low 10 medium (11.3) 11/6
Teicoplanin 0.5 10x none medium 60 medium (7.5) 91/83
  1. aDetermined in μg/ml for BB255 psas016-luc+. bDifference in MIC values of BB255/BB255ΔVraR. cEarliest time point at which induction was detected (min). dInduction levels were scored as: high (> 40'000 RLU); medium (>10'000 - < 40'000); low (< 10'000). eTime taken for maximum induction to be reached after antibiotic addition (min). fThe ratio of maximal induction levels measured at 5x MIC/0.2x MIC, scored as: high (> 15); medium (>2 - < 15); low (< 2). gOD and CFU/ml values after treatment with antibiotics (1x MIC) for 120 min, expressed as a percentage of the values from untreated cell.