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Table 2 The profile of proinflammatory cytokine and chemokine secretion of mDCs in response to C. parapsilosis

From: In vitro interactions of Candida parapsilosis wild type and lipase deficient mutants with human monocyte derived dendritic cells

  mDC (24 h)
(pg/ml) unstimulated Cpwt Cplip-/-
IL-1 α 21.90 (6.64- 70.46) 241.71 (19.78- 366.12) 487.97# (110.80- 548.77)
IL-6 159.26 (38.75- 226.87) 3934.41 (2481.7-6316.06) 6535.23# (3122.14-9215.14)
TNF α 99.51 (58.12-158.89) 1724.67 (736.08-2859.76) 3454.13# (2934.29-4139.50)
CXCL8 1632.81 (1358.45-2897.26) 3420.32 (3268-6563.96) 2657.64 (1846.33-3076.52)
  mDC (48 h)
(pg/ml) unstimulated Cp wt Cp lip-/-
IL-1 α 22.97 (11.17-40.30) 35.58 (11.19-68.98) 126.87# (59.90-198.21)
IL-6 4364.11 (4025.97-5410.58) 5873.19 (4767.13-7510.32) 7988.22# (6119.10-9893.27)
TNF α 124.92 (74.93-163.21) 3456.54 (1628.19-5686.98) 4345.39 (2694.78-5426.10)
CXCL8 2223.11 (898.14-4978.58) 2605.43 (1254.21-5297.94) 2392.44 (1226.74-5394.56)
  1. n = 8 independent blood donors
  2. Mature dendritic cells were stimulated with C. parapsilosis wild type (Cp wt), lipase deficient (Cp lip-/-) cells or left unstimulated. Secretion of IL-1α, IL-6, TNF-α or CXCL8 by iDCs was determined by Luminex analyzer or ELISA at 24 h and 48 h post-infection. †: medians (interquartile ranges) # p < 0.05