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Table 1 The profile of proinflammatory cytokine and chemokine secretion of iDCs in response to C. parapsilosis

From: In vitro interactions of Candida parapsilosis wild type and lipase deficient mutants with human monocyte derived dendritic cells

  iDC (24 h)
(pg/ml) unstimulated Cpwt Cplip-/-
IL-1 α 9.38 (8.20-11.19) 10.01 (8.34-11.17) 23.60# (19.88-26.74)
IL-6 175.77 (48.34-252.62) 3059.61 (1689.8-5880.12) 5636.54# (2792.25-7915.07)
TNF α 74.36 (55.71-115.78) 624.47 (522.57-736.08) 2836.59# (2822.29-3147.02)
CXCL8 794.23 (162.80-1226.77) 3622.8 (2047-5297.31) 3023.9 (1226.41-5297.31)
  iDC (48 h)
(pg/ml) unstimulated Cp wt Cp lip-/-
IL-1 α 7.85 (5.05-12.31) 15.45 (8.34-21.56) 22.14 (19.88-26.74)
IL-6 3573.23 (3201.12-4752.01) 5238.9 (3767.13-6082.85) 6968.16# (5398-8938.58)
TNF α 154.92 (115.71-194.82) 2342.12 (649.76-4333.62) 3947.27# (2433.01-5393.78)
CXCL8 1103.05 (656.02-1473.77) 1615.33 (942.11-1756.85) 1824.31 (1226.41-2491.06)
  1. n = 8 independent blood donors
  2. Immature dendritic cells were stimulated with C. parapsilosis wild type (Cp wt), lipase deficient (Cp lip-/-) cells or left unstimulated. Secretion of IL-1α, IL-6, TNFα or CXCL8 by iDCs was determined by Luminex analyzer or ELISA at 24 h and 48 h post-infection. †: medians (interquartile ranges) # p < 0.05