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Figure 5 | BMC Microbiology

Figure 5

From: Comparative proteomic analysis of Salmonella enterica serovar Typhimurium ppGpp-deficient mutant to identify a novel virulence protein required for intracellular survival in macrophages

Figure 5

STM3169 is a novel virulence protein. Competitive index was determined at 48 h after infection in the spleen (A). Effects of stm3169 disruption on the invasion (B) and the intracellular survival (C) in the mouse macrophage cell lines, RAW264.7. Cells treated with IFN-γ were infected with S. Typhimurium wild-type and the mutant strains at a multiplicity of infection of 1. At 2 h and 24 h after infection, macrophages were lysed and the bacterial number was determined. Asterisks indicate that differences were statistically significant (P < 0.05).

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