Global transcriptomic response of Leptospira interrogans serovar Copenhageni upon exposure to serum

BMC Microbiology

Table 4 Number of leptospiral genes differentially expressed in response to serum compared with the effects of temperature and osmolarity shifts^a

Serum effect	Temperature effect		Osmolarity effect		Temperature and osmolarity effect
	Up-regulated	Down-regulated	Up-regulated	Down-regulated	Up-regulated	Down-regulated
Up-regulated (%^b)	5 (9.1)	2 (3.6)	11 (20)	0 (0)	3 (5.6)	0 (0)
Down-regulated (%^c)	9 (8)	3 (2.7)	2 (1.8)	14 (12.4)	0 (0)	2 (1.8)

^acompared with previous microarray data of overnight 37°C [11] and osmolarity upshifts [13]
^bpercentage of genes up-regulated in response to serum and/or temperature and/or osmolarity shifts per total number of genes up-regulated in response to serum (55 genes)
^cpercentage of genes down-regulated in response to serum and/or temperature and/or osmolarity shifts per total number of genes down-regulated in response to serum (113 genes)

ISSN: 1471-2180