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Table 2 Genes of known or predicted function which were up-regulated in response to serum

From: Global transcriptomic response of Leptospira interrogans serovar Copenhageni upon exposure to serum

Gene ID a and COG category Gene Fold ratio Description of gene product Temperature effect b Osmolarity effect c
Information storage and processing      
- Transcription (K)      
LIC11154 (LA2894)   1.70 transcription regulator - -
LIC10378 (LA0431)   1.54 transcription regulator, PadR family - -
Cellular process and signaling      
- defense mechanisms (V)      
LIC12182 (LA1600)   1.58 ATP-binding protein of an ABC transporter complex - -
- signal transduction mechanisms (T)      
LIC12979 (LA0599)   2.49 signal transduction protein - -
LIC13289 (LA4127)   2.17 sensor histidine kinase of a two- component response regulator - d
LIC10900 (LA3235)   1.72 adenylate/guanylate cyclase - -
- cell wall/membrane biogenesis (M)      
LIC11149 (LA2901)   2.75 metallopeptidase - -
LIC12151 (LA1632)   2.45 nucleoside-diphosphate sugar epimerase - -
LIC10200 (LA0232)   2.17 glycosyltransferase - -
LIC10587 (LA3624)   2.07 glycosyltransferase - -
LIC11728 (LA2200)   2.01 amidase -
LIC13469 (LA4326) lpxD 1.65 UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase - -
- cell motility (N)      
LIC10464 (LA3778) ligB 1.89 LigB lipoprotein
- posttranslational modification, protein turnover, chaperones (O)      
LIC11657 (LA2280) fliS 1.98 endoflagellar biosynthesis chaperone - -
Metabolism      
- energy production and conversion (C)      
LIC10090 (LA0102)   1.73 conserved hypothetical protein (FOG: - -
    HEAT repeat)   
LIC20084 (LB107)   1.71 conserved hypothetical protein related to ferredoxin oxidoreductase - -
- carbohydrate transport and metabolism      
(G)   1.77 permease -
LIC20149 (LB187)      
- amino acid transport and metabolism (E)   1.69 acetyltransferase -
LIC12184 (LA1598)      
- nucleotide transport and metabolism (F) pyrD 2.01 dihydroorotate dehydrogenase - -
LIC13433 (LA4290) dgt 1.54 deoxyguanosinetriphosphate - -
LIC11663 (LA2274)    triphosphohydrolase   
- coenzyme transport and metabolism (H)   1.82 pyrimidine reductase -
LIC13208 (LA4019)   1.58 methylase/methyl transferase - -
LIC20082 (LB105) coaE 1.55 dephospho-CoA kinase - -
LIC13085 (LA3863)      
- lipid transport and metabolism (I)   2.59 fatty acid desaturase - -
LIC20052 (LB068) desA 2.59 fatty acid desaturase - -
LIC13053 (LA0502)   2.42 enoyl-CoA hydratase - -
LIC12629 (LA1032)      
- inorganic ion transport and metabolism hemO 2.47 heme oxygenase -
(P)   1.82 Reductase - -
LIC20148 (LB186)   1.69 cation transport ATPase, possibly copper -
LIC13470 (LA4327)   1.51 Bifunctional permease/carbonic anhydrase - -
LIC12982 (LA0594)      
LIC12992 (LA0579)      
  1. aGene ID is based on predicted ORFs of whole-genome sequence of L. interrogans serovar Copenhageni. Gene ID of corresponding serovar Lai is in parenthesis. ORFs of unknown or poorly characterized function were excluded from this table.
  2. bPrevious microarray data on the effect of overnight 37°C upshift [11] compared to growth at 30°C.
  3. cPrevious microarray data on the effect of osmolarity upshift [13] compared to EMJH medium.
  4. d ↑ represents up-regulation of gene expression and ↓ represents down-regulation of gene expression.