Identification of Lactobacillus plantarum genes modulating the cytokine response of human peripheral blood mononuclear cells

Table 2 L. plantarum genes with putative roles in modulating PBMC cytokine production.

Genes(s)	Gene number^a	Product	Percent of strains with the gene(s)^b	Gene-dependent contribution to cytokine stimulation^c
lp_1953	lp_1953	Hypothetical protein	48	IL-10	1.6-fold ↑
pts19ADCBR	lp_2647-2651	N-galactosamine PTS, EIIADCB and transcription regulator, GntR family	33	IL-10	1.7-fold ↓
plnEFI	lp_0419-0422	Immunity protein PlnI	81-85	IL-10/IL-12	1.7-fold ↓
		Bacteriocin-like peptide PlnF
		Bacteriocin-like peptide PlnE
plnG	lp_0423	ABC transporter	88	IL-10/IL-12	1.8-fold ↓
lamB	lp_3582	Accessory gene regulator protein	43	IL-10/IL-12	1.3-fold ↓
prophage P2b 1 & 21	lp_2460	Prophage P2b protein 21	38	IL-10/IL-12	1.5-fold ↑
	lp_2480	Prophage P2b protein 1, integrase

^aGene number on the L. plantarum WCFS1 chromosome [23].
^bPercentage of L. plantarum strains containing the gene according to CGH [27, 28].
^cGene-trait matching importance measures (in parentheses) and predicted effects of the gene(s) on the variable and average magnitude and direction (higher or lower) of IL-10 and IL-10/IL-12 amounts.

ISSN: 1471-2180