A three-phase in-vitro system for studying Pseudomonas aeruginosa adhesion and biofilm formation upon hydrogel contact lenses

Table 1 Properties of hydrogel contact lenses used in this study

Proprietary name	ACUVUE 2	PROCLEAR	BIOFINITY	AIROPTIX
United States Adopted Name (USAN)	Etafilcon A	Omafilcon A	Comfilcon A	Lotrafilcon B
Manufacturer	Johnson & Johnson	Cooper Vision	Cooper Vision	CIBA Vision
Water content (%)	58	62	48	33
Ionic charge	Ionic	Non-ionic	Non-ionic	Non-ionic
Oxygen permeability (Dk)	22	27	128	110
Centre thickness (mm) -3.00 D	0.084	0.065	0.08	0.08
Oxygen transmissibility (Dk/t) at 35°C	33.3	42	160	138
Basis curve (mm)	8.7	8.6	8.6	8.6
Diameter (mm)	14.0	14.2	14.0	14.2
Surface treatment	None	None	None	25-nm-thick plasma coating with high refractive index
FDA Group	4 (Conventional hydrogel)	2 (Conventional hydrogel)	1 (Silicone hydrogel)^α	1 (Silicone hydrogel)^β
Replacement and wearing schedule*	Every 2 weeks (daily wear) OR six nights extended wear	Every 4 weeks (daily wear)	Every 4 weeks (daily, continuous OR flexible wear)	Every 4 weeks (daily wear) OR up to six nights extended wear
Principal monomers	HEMA, MA	HEMA, PC	FM0411M, HOB, IBM, M3U, NVP, TAIC, VMA	DMA, TRIS, siloxane monomer

HEMA (poly-2-hydroxyethyl methacrylate); MA (methacrylic acid); PC (phoshoryl choline); DMA (N,N-dimethylacryl amide); TRIS (trimethylsiloxy silane); DMA, N,N-dimethylacrylamide; FM0411M (α-methacryloyloxyethyl iminocarboxyethyloxypropyl-poly(dimethylsiloxy)-butyldimethylsilane); HOB (2-hydroxybutyl methacrylate); IBM (isobornyl methacrylate); M3U αω -bis(methacryloyloxyethyl iminocarboxy ethyloxypropyl)-poly(dimethylsiloxane)-poly(trifluoropropylmethylsiloxane)-poly(ω methoxy- poly(ethyleneglycol)propylmethylsiloxane); NVP (N-vinyl pyrrolidone); TAIC (1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione); VMA (N-Vinyl-N-methylacetamide)
^α third silicone generation
^β first silicone generation
*It is recommended that the CL wearer first be evaluated on a daily wear schedule. If successful, then a gradual introduction of extended wear can be followed as determined by the prescribing Eye Care Practitioner.

ISSN: 1471-2180