| | | |
pncA mutation
|
|---|
|
M. tuberculosis strains (no. of isolates)
|
MGIT 960
|
PZase assay
|
Nucleotide change
|
Amino acid change
|
|---|
|
Susceptible (46)
|
S
|
+
|
wild-type
|
no
|
|
Susceptible (1)
|
S
|
+
|
T92G
|
Ile31Ser
|
|
Susceptible (2)
|
R
|
+
|
wild-type
|
wild-type
|
|
Susceptible (1)
|
R
|
+
|
T92C
|
Ile31Thr
|
|
MDR-TB (42)
|
S
|
+
|
wild-type
|
wild-type
|
|
MDR-TB (9)
|
S
|
+
|
T92C
|
Ile31Thr
|
|
MDR-TB (34)
|
R
|
-
|
A(-11)G (1)
|
no
|
| | | |
A(-11)C (1)
|
no
|
| | | |
T56G (1)
|
Leu19Arg
|
| | | |
T80C (1)
|
Leu27Pro
|
| | | |
T92G (2)
|
Ile31Ser
|
| | | |
T104C (1)
|
Leu35Pro
|
| | | |
T134C (1)
|
Val45Ala
|
| | | |
G136T (1)
|
Ala46Ser
|
| | | |
T199C (1)
|
Ser67Pro
|
| | | |
C211G (8)
|
His71Asp
|
| | | |
G215A (1)
|
Cys72Tyr
|
| | | |
G289A (3)
|
Gly97Ser
|
| | | |
C312G (2)
|
Ser104Arg
|
| | | |
G322C (1)
|
Gly108Arg
|
| | | |
G373T (1)
|
Val125Phe
|
| | | |
G379T (1)
|
Glu 127 Stop
|
| | | |
G394A (1)
|
Gly132Ser
|
| | | |
G insertion b/w 411-412 (1)
| |
| | | |
T416G (1)
|
Val 139 Gly
|
| | | |
C425T (1)
|
Thr 142 Met
|
| | | |
G436A (1)
|
Ala 146 Thr
|
| | | |
GG insertion b/w 520-521 (1)
| |
| | | |
C530T (1)
|
Thr 177 Ile
|
|
MDR-TB (11)
|
R
|
+
|
wild-type
|
no
|
|
MDR-TB (4)
|
R
|
+
|
T92C (3)
|
Ile31Thr
|
| | | |
T92G (1)
|
Ile31Ser
|
