pncA mutation | ||||
---|---|---|---|---|
M. tuberculosis strains (no. of isolates) | MGIT 960 | PZase assay | Nucleotide change | Amino acid change |
Susceptible (46) | S | + | wild-type | no |
Susceptible (1) | S | + | T92G | Ile31Ser |
Susceptible (2) | R | + | wild-type | wild-type |
Susceptible (1) | R | + | T92C | Ile31Thr |
MDR-TB (42) | S | + | wild-type | wild-type |
MDR-TB (9) | S | + | T92C | Ile31Thr |
MDR-TB (34) | R | - | A(-11)G (1) | no |
A(-11)C (1) | no | |||
T56G (1) | Leu19Arg | |||
T80C (1) | Leu27Pro | |||
T92G (2) | Ile31Ser | |||
T104C (1) | Leu35Pro | |||
T134C (1) | Val45Ala | |||
G136T (1) | Ala46Ser | |||
T199C (1) | Ser67Pro | |||
C211G (8) | His71Asp | |||
G215A (1) | Cys72Tyr | |||
G289A (3) | Gly97Ser | |||
C312G (2) | Ser104Arg | |||
G322C (1) | Gly108Arg | |||
G373T (1) | Val125Phe | |||
G379T (1) | Glu 127 Stop | |||
G394A (1) | Gly132Ser | |||
G insertion b/w 411-412 (1) | ||||
T416G (1) | Val 139 Gly | |||
C425T (1) | Thr 142 Met | |||
G436A (1) | Ala 146 Thr | |||
GG insertion b/w 520-521 (1) | ||||
C530T (1) | Thr 177 Ile | |||
MDR-TB (11) | R | + | wild-type | no |
MDR-TB (4) | R | + | T92C (3) | Ile31Thr |
T92G (1) | Ile31Ser |