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Table 1 List of commonly upregulated genes for all pathogens.

From: Gram-positive pathogenic bacteria induce a common early response in human monocytes

    

Fold Change

No.

Gene IDs

Gene Symbol

Gene name

LM

SA

SP

1

51561

IL23A

Interleukin 23, alpha subunit p19""

48,15

30,02

6,70

2

57124

CD164L1

CD248 antigen, endosialin""

20,36

22,03

8,23

3

3426

IF

I factor (complement)

17,07

13,08

6,88

4

10411

RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

13,85

11,81

5,60

5

1960

EGR3

Early growth response 3

12,16

8,98

2,65

6

3725

JUN

V-jun sarcoma virus 17 oncogene homolog (avian)

10,80

12,09

6,35

7

9389

SLC22A14

Solute carrier family 22 (organic cation transporter), member 14""

10,41

9,29

5,40

8

6648

SOD2

Superoxide dismutase 2, mitochondrial""

10,24

8,61

4,23

9

3290

HSD11B1

Hydroxysteroid (11-beta) dehydrogenase 1

10,04

20,04

5,73

10

122616

C14orf79

Chromosome 14 open reading frame 79

9,27

8,15

4,45

11

4790

NFKB1

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)

8,03

8,17

3,06

12

131566

DCBLD2

Discoidin, CUB and LCCL domain containing 2""

7,94

5,46

4,59

13

1906

EDN1

Endothelin 1

7,76

10,71

3,40

14

9025

RNF8

Ring finger protein 8

7,38

6,01

2,98

15

51458

RHCG

Rhesus blood group, C glycoprotein""

6,90

8,94

2,55

16

1735

DIO3

Deiodinase, iodothyronine, type III""

6,83

6,20

3,70

17

9021

SOCS3

Suppressor of cytokine signaling 3

6,82

9,90

3,10

18

83740

H2AFB3

H2A histone family, member B3""

6,69

8,58

3,55

19

9028

RHBDL1

Rhomboid, veinlet-like 1 (Drosophila)""

6,18

5,07

2,28

20

8659

ALDH4A1

Aldehyde dehydrogenase 4 family, member A1""

6,13

3,74

3,02

21

8740

TNFSF14

Tumor necrosis factor (ligand) superfamily, member 14""

5,74

3,83

1,60

22

51025

Magmas

Mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction

5,52

5,54

3,11

23

10120

ACTR1B

ARP1 actin-related protein 1 homolog B, centractin beta (yeast)""

5,17

4,63

2,70

24

2615

GARP

Leucine rich repeat containing 32

4,96

3,18

3,03

25

55655

NALP2

NACHT, leucine rich repeat and PYD containing 2""

4,72

4,59

2,83

26

6004

RGS16

Regulator of G-protein signalling 16

4,66

2,42

2,22

27

6935

TCF8

Transcription factor 8 (represses interleukin 2 expression)

4,66

2,81

7,11

28

3280

HES1

Hairy and enhancer of split 1, (Drosophila)""

4,65

4,37

2,02

29

983

CDC2

Cell division cycle 2, G1 to S and G2 to M""

4,64

4,21

2,31

30

9076

CLDN1

Claudin 1

4,60

4,85

2,59

31

10307

APBB3

Amyloid beta (A4) precursor protein-binding, family B, member 3""

4,53

3,47

2,90

32

283131

TncRNA

Trophoblast-derived noncoding RNA

4,29

5,03

2,53

33

114112

TXNRD3

Thioredoxin reductase 3

4,15

3,55

2,01

34

6355

CCL8

Chemokine (C-C motif) ligand 8

4,06

3,54

2,54

35

1164

CKS2

CDC28 protein kinase regulatory subunit 2

3,95

3,12

2,11

36

5142

PDE4B

Phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)""

3,93

3,93

2,35

37

6358

CCL14

Chemokine (C-C motif) ligand 14

3,80

4,33

3,76

38

788

SLC25A20

Solute carrier family 25 (carnitine/acylcarnitine translocase), member 20""

3,72

3,69

2,55

39

3697

ITIH1

Inter-alpha (globulin) inhibitor H1

3,71

3,12

2,05

40

2322

FLT3

Fms-related tyrosine kinase 3

3,66

4,59

2,20

41

6489

SIAT8A

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1""

3,47

3,23

2,67

42

23529

CLC

Cardiotrophin-like cytokine factor 1

3,33

7,64

2,12

43

55647

RAB20

RAB20, member RAS oncogene family""

3,31

3,86

3,95

44

54847

SIDT1

SID1 transmembrane family, member 1""

3,15

4,43

2,78

45

10514

MYBBP1A

MYB binding protein (P160) 1a

3,09

5,53

2,35

46

64108

IFRG28

28 kD interferon responsive protein

3,08

2,48

2,22

47

9590

AKAP12

A kinase (PRKA) anchor protein (gravin) 12

2,99

2,72

2,09

48

5894

RAF1

V-raf-1 murine leukemia viral oncogene homolog 1

2,97

2,75

2,19

49

51365

PLA1A

Phospholipase A1 member A

2,95

4,52

2,45

50

6696

SPP1

Secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)""

2,93

5,05

1,70

51

1939

LGTN

Ligatin

2,80

3,90

2,15

52

57801

HES4

Hairy and enhancer of split 4 (Drosophila)

2,78

2,72

2,13

53

3202

HOXA5

Homeo box A5

2,76

2,07

2,37

54

4216

MAP3K4

Mitogen-activated protein kinase kinase kinase 4

2,68

3,54

2,05

55

481

ATP1B1

ATPase, Na+/K+ transporting, beta 1 polypeptide""

2,65

2,04

2,27

56

1466

CSRP2

Cysteine and glycine-rich protein 2

2,64

8,75

3,66

57

11182

SLC2A6

Solute carrier family 2 (facilitated glucose transporter), member 6""

2,48

2,46

2,00

58

83660

TLN2

Talin 2

2,41

2,26

2,21

59

7003

TEAD1

TEA domain family member 1 (SV40 transcriptional enhancer factor)

2,40

1,92

2,11

60

85378

TUBGCP6

Tubulin, gamma complex associated protein 6""

2,40

2,72

2,46

61

1846

DUSP4

Dual specificity phosphatase 4

2,38

2,92

2,60

62

7422

VEGF

Vascular endothelial growth factor

2,30

2,27

2,10

63

10560

SLC19A2

Solute carrier family 19 (thiamine transporter), member 2""

2,10

2,45

2,90

64

6617

SNAPC1

Small nuclear RNA activating complex, polypeptide 1, 43 kDa""

2,05

2,65

2,38

65

6515

SLC2A3

Solute carrier family 2 (facilitated glucose transporter), member 3""

2,04

2,57

2,36

66

136

ADORA2B

Adenosine A2b receptor

1,90

1,79

1,72

  1. FDR 10. LM: L. monocytogene s EGDe, SA: S. aureu s, SP: S. pneumoniae.
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BMC Microbiology

ISSN: 1471-2180

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