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Table 2 Extra protein motifs in mycobacterial rhomboids

From: Rhomboid homologs in mycobacteria: insights from phylogeny and genomic analysis

Species/strain Rhomboid Number of aTMHs TMH with active Site Extra motif E-value Target signal
bH37Rv Rv0110 7 4 & 6 DUF17511 0.27 Mitochondrial
     Siva2 0.68  
     Zf-B_box3 0.00021  
M. marinum MMAR_0300 7 4 & 6 Zf-B_box 0.00012 Other
     FixQ4 0.016  
M. ulcerans MUL_4822 7 4 & 6 EcsB5 0.17 Mitochondrial
cM. sp Jls Mjls_5528 7 4 & 6 IBR6 0.301 Other
     Zf-B_box 0.013  
     Dynactin p627 0.24  
     Tim178 0.36  
M. vanbaalenii Mvan_5753 7 4 & 6 Zf-B_box 0.0044 Other
     Dynactin p62 0.11  
     DUF1751 0.028  
M. gilvum Mflv_1071 7 4 & 6 Zf-B_box 0.015 Other
     DUF1751 0.02  
M. smegmatis MSMEG_5036 7 4 & 6 -   Mitochondrial
M. abscessus MAB_0026 7 4 & 6 Zf-B_box 0.0064 Other
H37Rv Rv1337 6 4 & 6 CBM_19 0.17 Mitochondrial
M. marinum MMAR_4059 6 4 & 6 C_GCAxxG_C_C10 0.0062 Secretory
M. avium MAV_1554 6 4 & 6 C_GCAxxG_C_C 0.0099 Secretory
M. leprae ML1171 6 4 & 6 C_GCAxxG_C_C 0.031 Other
M. abscessus MAB_1481 6 4 & 6 -   Other
M. smegamatis MSMEG_4904 5 3 & 5 C_GCAxxG_C_C 0.025 Secretory
M. sp Jls Mjls_3833 5 3 & 5 DUF215411 0.6 Secretory
M. vanbaalenii Mvan_4290 5 3 & 5 -   Secretory
M. gilvum Mflv_2355 5 3 & 5 -   Secretory
  1. The rhomboid family domain was excluded
  2. -: Extra domain not detected
  3. Other: cellular localization target other than secretory and mitochondrial
  4. a: Transmembrane helices
  5. b: Mycobacterium tuberculosis
  6. c: Mycobacterium species Jls
  7. 1: Eukaryotic integral membrane protein
  8. 2: Cd27 binding protein
  9. 3: B-box zinc finger
  10. 4:Cbb3-type cytochrome oxidase component
  11. 5: Bacterial ABC transporter protein
  12. 6: In Between Ring 'IBR' fingers
  13. 7: Dynactin p62 family
  14. 8: Tim17/Tim22/Tim23 family
  15. 9: Fungal cellulose binding domain
  16. 10: Putative redox-active protein
  17. 11: Predicted membrane protein