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Table 2 List of the 23 differentially expressed proteins found in rifampicin resistant Neisseria meningitidis strains

From: Neisseria meningitidis rifampicin resistant strains: analysis of protein differentially expressed

Spot n Protein name (gene) a Protein accession number Ordered Locus Nameb Sequence coverage % Mowse Score MWt/pIt Expression level c UniProtKB Functional classification d
1 Aconitate hydratase (acn B) A1KUZ6 NMC1492 51 403 93412/5.38 up Carbohydrate metabolism: TCA cycle
2 Piruvate dehydrogenase subunit E1 (ace E) A1KUG5 NMC1278 53 426 99915/5.60 up Carbohydrate metabolism: pyruvate metabolism
3 Putative phosphoenolpyruvate synthase (pps A) A1KSM6 NMC0561 26 165 87128/6.01 up Carbohydrate metabolism: pyruvate metabolism
4 Elongation factor G (fus A) A1KRH0 NMC0127 30 245 77338/5.08 up Genetic Information Processing: protein synthesis
5 Isocitrate dehydrogenase (icd) A1KTJ0 NMC0897 27 229 80313/5.53 up* Carbohydrate metabolism: TCA cycle
6 60 kDa chaperonin (gro L) A1KW52 NMC1948 41 206 57535/4.90 down Genetic Information Processing: protein folding
7 ATP synthase subunit α (atp A) A1KW13 NMC1908 62 281 55481/5.50 down Energy metabolism: oxidative phosphorilation
8 N utilisation substance protein A (nus A) A1KV50 NMC1556 71 426 55745/4.54 up Genetic Information Processing: protein synthesis
9 Putative phosphate acyltransferase (NMC0575) A1KSN9 NMC0575 47 263 57551/5.47 up* Carbohydrate metabolism: propanoate metabolism
10 Probable malate:quinone oxidoreductase (mqo) A1KWH2 NMC2076 36 178 54091/5.58 down Carbohydrate metabolism: TCA cycle
11 Trigger factor (tig) A1KUE0 NMC1250 51 209 48279/4.76 down Genetic Information Processing: protein folding
12 Enolase (eno) A1KUB6 NMC1220 25 129 46319/4.78 down Carbohydrate metabolism: glycolysis
13 Cell division protein (fts A) A1KVK9 NMC1738 40 132 44348/5.33 down Genetic Information Processing: cell division
14 Glutamate dehydrogenase (gdh A) A1KVB4 NMC1625 54 221 48731/5.80 up Energy metabolism: amino acid metabolism
15 Putative zinc-binding alcohol dehydrogenase (NMC0547) A1KSL2 NMC0547 38 235 38283/5.32 down* Carbohydrate metabolism: butanoate metabolism
16 Succinyl-CoA ligase [ADP-forming] subunit beta (suc C) A1KTM6 NMC0935 26 125 41567/5.01 up Carbohydrate metabolism: TCA cycle
17 DNA-directed RNA polymerase subunit α (rpo A) A1KRJ9 NMC0158 41 184 36168/4.94 up Genetic Information Processing: transcription
18 Carboxyphosphonoenol pyruvate phosphonomutase (prp B) A1KVK6 NMC1733 73 234 31876/5.22 down Carbohydrate metabolism: propanoate metabolism
19 Putative malonyl Co-A acyl carrier protein transacylase (fab D) A1KRY7 NMC0305 57 158 31958/5.44 down Lipid metabolism: fatty acid biosynthesis
20 Septum site-determining protein (min D) A1KRK2 NMC0161 29 143 29768/5.70 down Genetic Information Processing: cell division
21 Putative two-component system regulator (NMC0537) A1KSK4 NMC0537 74 181 24821/5.44 down Environmental Information Processing: signal transduction
22 Peptidyl-prolyl cis-trans isomerase (ppi B) A1KT50 NMC0744 84 260 18840/5.04 down Genetic Information Processing: protein folding
23 Putative oxidoreductase (NMC0426) A1KSA1 NMC0426 52 129 20759/5.74 down* -
  1. a According to the UniProtKB/TrEMBL entry http://www.uniprot.org/.
  2. bOrdered Locus Name in Neisseria meningitidis serogroup C/serotype 2a (strain ATCC 700532/FAM18)
  3. c Expression level of RIF R versus RIF S strains.
  4. d Functional classification of the proteins according to KEGG: Kyoto Encyclopedia of Genes and Genomes http://www.genome.jp/kegg/.
  5. *Protein with changed pI in RIF R versus RIF S isolate.