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Table 3 The SNP genotypes of MMPs and TIMPs in the both genders with different clinical diagnoses

From: Matrix metalloproteinase-3 promoter polymorphisms but not dupA-H. pylori correlate to duodenal ulcers in H. pylori-infected females

Genotype Female Male
N (%) Gastritis DU GU P a P b Gastritis DU GU P a P b
MMP-3           
   5A carrier 46 (25.1) 7 (12.3) 8 (22.2) 0.04 0.71 28 (34.1) 15 (24.6) 11 (21.6) 0.22 0.12
   6A/6a 137 (74.9) 50 (87.7) 28 (77.8)    54 (65.9) 46 (75.4) 40 (78.4)   
MMP-7           
   A/A 150 (82.9) 45 (80.4) 32 (91.4)   0.31 72 (88.9) 52 (86.7) 39 (76.5) 0.69 0.06
   G carrier 31 (17.1) 11 (19.6) 3 (8.6) 0.67   9 (11.1) 8 (13.3) 12 (23.5)   
MMP-9           
   A carrier 78 (42.6) 19 (33.3) 15 (41.7) 0.21 0.92 25 (30.5) 22 (36.1) 22 (43.1) 0.48 0.14
   G/G 105 (57.4) 38 (66.7) 21 (58.3)    57 (69.5) 39 (63.9) 29 (56.9)   
TIMP-1            
♀ T carrier ♂ T 148 (80.9) 41 (73.2) 29 (80.6) 0.22 0.97 46 (56.8) 31 (50.8) 26 (51.0) 0.48 0.51
   C/C C 35 (19.1) 15 (26.8) 7 (19.4)    35 (43.2) 30 (49.2) 25 (49.0)   
TIMP-2           
   C carrier 54 (30.2) 17 (32.1) 10 (28.6) 0.79 0.85 27 (33.3) 20 (32.3) 13 (25.5) 0.89 0.34
   G/G 125 (69.8) 36 (67.9) 25 (71.4)    54 (66.7) 42 (67.7) 38 (74.5)   
  1. Abbreviations: DU, duodenal ulcer; GU, gastric ulcer. The p value was determined by Fisher's exact test or χ2 test. a indicated significance with p < 0.05 of such parameter between gastritis and duodenal ulcer; b between gastritis and gastric ulcer. Genotype distribution of SNP in cases and control was in Hardy-Weinberg equilibrium (p < 0.05).