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Table 3 The SNP genotypes of MMPs and TIMPs in the both genders with different clinical diagnoses

From: Matrix metalloproteinase-3 promoter polymorphisms but not dupA-H. pylori correlate to duodenal ulcers in H. pylori-infected females

Genotype

Female

Male

N (%)

Gastritis

DU

GU

P a

P b

Gastritis

DU

GU

P a

P b

MMP-3

          

   5A carrier

46 (25.1)

7 (12.3)

8 (22.2)

0.04

0.71

28 (34.1)

15 (24.6)

11 (21.6)

0.22

0.12

   6A/6a

137 (74.9)

50 (87.7)

28 (77.8)

  

54 (65.9)

46 (75.4)

40 (78.4)

  

MMP-7

          

   A/A

150 (82.9)

45 (80.4)

32 (91.4)

 

0.31

72 (88.9)

52 (86.7)

39 (76.5)

0.69

0.06

   G carrier

31 (17.1)

11 (19.6)

3 (8.6)

0.67

 

9 (11.1)

8 (13.3)

12 (23.5)

  

MMP-9

          

   A carrier

78 (42.6)

19 (33.3)

15 (41.7)

0.21

0.92

25 (30.5)

22 (36.1)

22 (43.1)

0.48

0.14

   G/G

105 (57.4)

38 (66.7)

21 (58.3)

  

57 (69.5)

39 (63.9)

29 (56.9)

  

TIMP-1

           

♀ T carrier

♂ T

148 (80.9)

41 (73.2)

29 (80.6)

0.22

0.97

46 (56.8)

31 (50.8)

26 (51.0)

0.48

0.51

   C/C

C

35 (19.1)

15 (26.8)

7 (19.4)

  

35 (43.2)

30 (49.2)

25 (49.0)

  

TIMP-2

          

   C carrier

54 (30.2)

17 (32.1)

10 (28.6)

0.79

0.85

27 (33.3)

20 (32.3)

13 (25.5)

0.89

0.34

   G/G

125 (69.8)

36 (67.9)

25 (71.4)

  

54 (66.7)

42 (67.7)

38 (74.5)

  
  1. Abbreviations: DU, duodenal ulcer; GU, gastric ulcer. The p value was determined by Fisher's exact test or χ2 test. a indicated significance with p < 0.05 of such parameter between gastritis and duodenal ulcer; b between gastritis and gastric ulcer. Genotype distribution of SNP in cases and control was in Hardy-Weinberg equilibrium (p < 0.05).
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BMC Microbiology

ISSN: 1471-2180

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