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Table 5 MIC Assay of Az for F. novicida transposon mutants.

From: Azithromycin effectiveness against intracellular infections of Francisella

Bacteria AZ MIC (μg/ml) AZ EC50(μg/ml) p-value
F. novicida 0.78 0.16 ------
wbtQ 3.12 0.52 0.005
wbtN 12.5 0.54 <0.002
wbtE 25 0.50 <0.001
wbtA 12.5 0.67 0.007
dsbB 1.56 0.16 0.401
ftlC 25 13.47 <0.002
tolC 50 16.44 <0.001
acrA 50 12.39 <0.001
acrB 50 13.23 0.001
F. tularensis Schu S4 0.78 0.1453 -------
ΔacrA 3.13 0.0852 0.087
ΔacrB 1.56 0.0493 0.031
  1. MIC and EC50 were calculated as described. p-values compare the EC50 of mutants to wild-type F. novicida and F. tularensis Schu S4.