Skip to main content

Table 5 MIC Assay of Az for F. novicida transposon mutants.

From: Azithromycin effectiveness against intracellular infections of Francisella

Bacteria

AZ MIC (μg/ml)

AZ EC50(μg/ml)

p-value

F. novicida

0.78

0.16

------

wbtQ

3.12

0.52

0.005

wbtN

12.5

0.54

<0.002

wbtE

25

0.50

<0.001

wbtA

12.5

0.67

0.007

dsbB

1.56

0.16

0.401

ftlC

25

13.47

<0.002

tolC

50

16.44

<0.001

acrA

50

12.39

<0.001

acrB

50

13.23

0.001

F. tularensis Schu S4

0.78

0.1453

-------

ΔacrA

3.13

0.0852

0.087

ΔacrB

1.56

0.0493

0.031

  1. MIC and EC50 were calculated as described. p-values compare the EC50 of mutants to wild-type F. novicida and F. tularensis Schu S4.