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Table 1 Comparison between the lesion profiles in the different immunosuppressive conditions.

From: In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis

   Lesions Recruted Inflammatory Cells Fungi
   Proportion of inflammatory infiltrate surface Major Localisation Necrosis Neutrophiles Macrophages Conidia Hyphae
Chlodrolip Early
1 day PI
1.8 ± 1.0% Random
distribution
- ++ +/- ++ -
  Late
8 days PI
2.9 ± 1.7% Perivascular
Peribronchiolar
- - + + -
Cortisone Acetate        
  Early
1 day PI
3.8 ± 2.0% Alveoli ++ ++ +/- ++ +/-
  Late
3 days PI
11.2 ± 1.9% Bronchi
Bronchioles
+++ +++ ++ ++ +++
RB6-8C5        
  Early
1 day PI
1.9 ± 0.5% Random
distribution
+/- - +/- + -
  Late
3 days PI
18.9 ± 2.8% Bronchi
Bronchioles
+++ - +++ ++ +++
Cyclophosphamide        
  Early
1 day PI
No infiltrate Bronchioles +/- +/- - +/- -
  Late
3 days PI
No infiltrate All structures ++++ - - + ++++
  1. A group of five mice was studied at each time point, for each condition. The lesions were very similar between the different animals in a same group (PI: post-infection). A group of three mice was studied for the measurement of the surface of inflammatory cell infiltrates in tissue sections (morphometric analysis, 22 to 40 microscopic fields covering an entire lung section for each animal).
  2. - none, +/- minimal, + mild, ++ moderate, +++ marked, ++++ severe