In the late stage after RB6-8C5 treatment, macrophages and recruited monocytes were unable to prevent fungal lung colonisation. (A): Multifocal large inflammatory infiltrates centred on bronchioles but extending to alveoli and blood vessels (arrowheads). (B): Fungi displayed a high infiltrative potential with a marked extension to alveoli (arrowheads). (C): Inflammatory infiltrates were composed of mononucleated cells; mainly macrophages (inlay). (D): Hyphae were mature and displayed a high invasive potential. A, C: HE staining; B, D: GMS staining.