Skip to main content

Table 2 Macrophage genes with decreased expression in M. avium 109 but increased in 2D6 mutant 4 h post infection

From: Virulence-related Mycobacterium avium subsp hominissuis MAV_2928 gene is associated with vacuole remodeling in macrophages

Gene Gene Bank ID Name Function Fold induction (± SD) p value <0.05
AMBP X04494 Alpha-1-microglobulin Negative regulation of immune response/Protease inhibitor 4.2 ± 0.7 Y
BLK BC004473 B-lymphoid tyrosine kinase Apoptosis 3.3 ± 0.3 Y
BMX AF045459 BMX non-receptor tyrosine kinase Intracellular signaling 18.6 ± 4.1 Y
CCR3 AF247361 Chemokine receptor 3 Signal transduction 4.1 ± 0.6 Y
CD53 BC040693 CD53 molecule Growth regulation 4.1 ± 0.3 Y
CETN2 X72964 Centrin, EF-hand protein 2 Microtubule organization center 6.3 ± 0.9 Y
CHP NP_009167 Calcium binding protein P22 Potassium channel regulator/Signal transduction 20.8 ± 3.5 Y
CR1 Y00816 Complement receptor 1 Bacterial uptake 4.3 ± 0.4 Y
CTSG NM_001911 Cathepsin G Bacterial killing 2.9 ± 0.2 Y
DCTN1 NM_004082 Dynactin 1 Lysosome and endosome movement 35.8 ± 8.0 Y
DDOST D29643 Dolichyl-diphosphooligosaccharide-protein glycosyltransferase N-linked glycosylation 3.3 ± 0.3 Y
DGKG AF020945 Diacylglycerol kinase gamma Intracellular signaling 5.3 ± 0.6 Y
DGKZ U51477 Diacylglycerol kinase zeta Intracellular signaling 48.1 ± 6.1 Y
EMILIN2 AF270513 Elastin microfibril interfacer 2 Cell adhesion 14.7 ± 3.7 Y
FOXC2 Y08223 Forkhead box C2 Transcription factor 5.9 ± 1.5 Y
GABBR1 Y11044 GABA receptor 1 Signal transduction 6.1 ± 2.0 Y
GABBR2 AF069755 GABA receptor 2 Signal transduction 2.8 ± 0.4 Y
GPR17 NM_005291 G-protein coupled receptor 17 Signal transduction 83.2 ± 12.5 Y
GZMA NM_006144 Granzyme A Apoptosis 2.1 ± 0.6 Y
IFNA1 NM_024013 Interferon alpha 1 Intracellular signaling 2.6 ± 1.0 Y
IL10RA U00672 Interleukin 10 receptor alpha Inhibition of proinflammatory cytokine synthesis 2.3 ± 0.2 Y
ITGB1 BC020057 Fibronectin receptor Bacterial uptake 4.6 ± 0.7 Y
LCP2 NM_005565 Lymphocyte cytosolic protein 2 Immune response 37.5 ± 9.2 Y
MCAM X68264 Melanoma cell adhesion molecule Cell adhesion 4.7 ± 0.2 Y
MS4A1 M27394 Membrane-spanning 4-dmains Immune response 9.6 ± 0.9 Y
PBX2 NM_002586 Pre-B-cell leukemia transcription factor 2 Transcriptional activator 3.0 ± 0.3 Y
PLTP NM_006227 Phospholipid transfer protein Lipid metabolism 3.6 ± 0.5 Y
RAB7 X93499 RAS related GTP binding protein Vesicular transport regulation 3.4 ± 0.4 Y
RAB13 X75593 RAS related GTP binding protein Small GTPase mediated signal transduction 7.5 ± 1.1 Y
RGS12 AF035152 Regulator of G-protein signaling 12 Negative regulation of G-protein signaling 3.0 ± 0.3 Y
RGS13 AF030107 Regulator of G-protein signaling 13 Negative regulation of G-protein signaling 2.6 ± 0.4 Y
S100A11 NM_005620 Calgizzarin Motility, invasion & tubulin polymerization 9.6 ± 0.8 Y
TNFRSF17 Z29574 TNF receptor Immune response 2.6 ± 0.3 Y
TUBB AB062393 Tubulin beta Microtubule based movement 4.0 ± 0.3 Y
YWHAZ NM_003406 Tyrosine 3-monooxygenase Signal transduction 4.3 ± 0.5 Y
  1. Complemented 2D6 mutant had similar results to the wild-type bacterium. Y = Yes; N = No