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Fig. 7 | BMC Microbiology

Fig. 7

From: Development of non-alcoholic steatohepatitis is associated with gut microbiota but not with oxysterol enzymes CH25H, EBI2, or CYP7B1 in mice

Fig. 7

Summary of the evidence and model of the interplay between gut microbiota, oxysterol synthesizing enzymes and NASH: Levels of 24- and 7 hydroxylated oxysterol in liver biopsies are elevated in human NASH (upper left [31]). In a murine feeding model of NASH, relative abundance of some bacterial taxa of the intestinal differed between animals with and without NASH. Because of limits in the taxonomic resolution some OTUs with identical assignment were found in both conditions. Mechanistic effects of the intestinal microbiota and NASH have not been addressed by the current study but microbial metabolites absorbed from the intestine might mediate the induction of liver inflammation

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BMC Microbiology

ISSN: 1471-2180

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