Fig. 2
From: Effects of hepatitis C virus core protein and nonstructural protein 4B on the Wnt/β-catenin pathway
HCV core protein and NS4B enhance the β-catenin/Tcf-dependent transcriptional activity in Huh7 cells or LO2 cells under Wnt3a induction. a Relative luciferase activity of pTOP/pFOP in Huh7 cells. HCV core protein and NS4B enhance the β-catenin/Tcf-dependent transcriptional activity in Huh7 stable cell line. Compared with Huh7-mkate2, ** P < 0.01. b Relative luciferase activity of pTOP/pFOP in LO2 cells non-Wnt3a stimulation, stimulated by 100 ng/ml Wnt3a, stimulated by 200 ng/ml Wnt3a. HCV core protein and NS4B stabilize the β-catenin/Tcf-dependent transcriptional activity in LO2 stable cell line under Wnt3a induction. ** P < 0.01