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Table 6 UTI89 genes downregulated in J82 BECs. BLAST results of hypothetical proteins are represented in parentheses. Genes located on the UTI89 plasmid are marked in bold

From: DFI-seq identification of environment-specific gene expression in uropathogenic Escherichia coli

Genes downregulated during growth in J82 BECs

Protein

Number of genes in operon

rLogFC

repB

replication protein

1

2,011113132

htgA

positive regulator for sigma 32 heat shock promoters

1

1,890514455

UTI89_P010

hypothetical protein (iron permease/transporter (membrane protein))

1

1,861559188

ribF

bifunctional riboflavin kinase/FMN adenylyltransferase

1

1,859516233

yaaY

hypothetical protein

1

1,848940285

ydiA

hypothetical protein

1

1,753697215

gyrB

DNA gyrase subunit B

1

1,74780503

rob

right origin-binding protein

1

1,738152589

yajK

thiamine biosynthesis protein ThiI

1

1,638543917

creA

hypothetical protein (protein CreA (Catabolite regulation protein A))

1

1,635400678

ytfB

hypothetical protein (Opacity-associated protein A)

1

1,617894201

UTI89_P053

hypothetical protein

1

1,614324659

yjjX

NTPase

1

1,60329406

UTI89_P144

hypothetical protein (putative endonuclease)

1

1,577892223

yccW

hypothetical protein (ribosomal RNA large subunit methyltransferase)

1

1,516636602

UTI89_P046; UTI89_P047

hypothetical serine-threonine protein kinase

hypothetical protein

2

1,513872693