Fig. 5

Network interaction analysis of proteins related to Nm. Known and predicted protein-protein interactions of the differentially abundant proteins were extracted from STRING database. Graphical representation of the interaction was generated by cytoscape software version 3.4. Proteins are represented as nodes, and the biological relationship between two nodes is represented as an edge (line). The intensity of the node color indicates the increased (red) or decreased (green) abundance according to fold changes. Those non-highlighted nodes were not in the input list but identified by STRING database as interacting partners. Dash-lined circle indicates sub-network of proteins linked to specific KEGG pathways. Core metabolic pathways (1); DNA transformation and recombination (2); Response to oxidative stress (3)