Table 1 Mode of action of different classes of antibiotics
From: Characterization and prediction of the mechanism of action of antibiotics through NMR metabolomics
Mode of action | Action | Antibiotics |
|---|---|---|
Cell wall synthesis inhibitors: Inhibition of penicillin binding proteins (PBPs) | bactericidal | ß-lactam-antibiotics Penicillin-derivatives: Ampicillin, Carbenicillin Cephalosporin-derivatives: Cefalexin |
DNA and protein synthesis inhibitors: Inhibition of topoisomerase | bactericidal | Fluoroquinolones Ofloxacin, Ciprofloxacin |
Protein synthesis inhibitors: Inhibition of 30s subunit | bacteriostatic | Tetracycline derivatives Tetracycline, Doxycycline |
Protein synthesis inhibitors: Inhibition of 30s subunit | bactericidal | Aminoglycosides Kanamycin, Streptomycin |