Figure 4

FimH mediates opsonised E. coli adherence and invasion of PTECs. Adherence assays (A) and internalisation assays (B) were performed in the presence of 5% NHS. The type 1 fimbriated E. coli cystitis isolates, NU14 is more efficient at adhering to and internalisation into PTEC than the isogenic fimH^- mutant, NU14-1 (*, P < 0.005). Data are shown as Mean ± SEM [n = 3 (for adherence assay) or n = 4 for (internalisation assays)], a representative of three independent experiments.