Different bacterial gene expression patterns and attenuated host immune responses are associated with the evolution of low-level vancomycin resistance during persistent methicillin-resistant Staphylococcus aureusbacteraemia

Table 2 Urease assay results and comparison to microarray results

		VISA/VSSA fold ratio
Strain	Urease activity (μmol urea min^-1 mg protein^-1)	urease assay	microarray (*ureA*)
Pair 1
JKD 6000	0.0
JKD 6001	8.2	>8.2	3.75*
Pair 2
JKD 6009	3.9
JKD 6008	6.8	1.7	1.40
Pair 3
JKD 6021	3.7
JKD 6023	17.1	4.6	1.82*
Pair 4
JKD 6052	3.8
JKD 6051	5.17	1.5	2.69*
Pair 5
JKD 6004	2.3
JKD 6005	1.5	0.65	0.73

Abbreviations: VSSA, vancomycin-susceptible S. aureus; VISA, vancomycin intermediate S. aureus.
*Microarray fold ratios were statistically significant.

ISSN: 1471-2180