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Table 2 LSMMG E. coli MG1655 genes down-regulated compared to the control in minimal MOPS medium.

From: Characterization of Escherichia coli MG1655 grown in a low-shear modeled microgravity environment

Gene

b#

Contran

Ave. Fold Change

Average p-value

Gene Product

Product Location

Present in S. Typhimurium

yaiN

b0357

 

-2.28

0.0013

orf, hypothetical protein

 

orthologue

copA

b0484

 

-2.21

0.0012

Cu-translocating P-type ATPase resistance pump

inner mem.

present

renD

b0542

yes

-2.02

0.0005

orf, phage λ ren gene homolog

lysis

 

emrE

b0543

yes

-2.02

0.0001

multidrug resistance pump, methylviologen resistance

inner mem.

orthologue

essD

b0554

yes

-2.57

0.0001

orf, phage lambda S lysis protein homolog

mem. lysis

 

ybcS

b0555

yes

-2.19

0.0001

orf, bacteriophage lambda lysozyme homolog

wall lysis

orthologue

rzpD

b0556

yes

-2.41

0.0001

orf, bacteriophage lambda endopeptidase homolog

mem. disrpt.

orthologue

ybcH

b0567

 

-3.17

0.0000

orf, hypothetical protein

  

cusC

b0572

yes

-2.57

0.0002

outer mem. factor of CusABC Ag & Cu efflux system

outer mem.

orthologue

cusF

b0573

yes

-4.06

0.0001

Ag & Cu periplasmic binding protein, chaperone

periplasm

 

cusB

b0574

yes

-2.16

0.0001

CusABC Ag & Cu efflux periplasmic fusion protein

periplasm

 

cusA

b0575

yes

-3.26

0.0001

inner mem. factor of CusABC Ag & Cu transporter

inner mem.

orthologue

ybdF

b0579

 

-2.47

0.0005

orf, hypothetical protein

  

uspG

b0607

 

-2.55

0.0003

universal stress protein of UspA family, heat shock

cytoplasm

present

yfiA

b2597

 

-2.50

0.0007

30S ribosome stabilizing subunit, cold shock response

cytoplasm

present

accB*

b3255

 

-2.64

0.0001

acetylCoA carboxylase, BCCP subunit; fatty acid bios.

cytoplasm

present

cpxP

b3913/14

 

-2.50

0.0002

Cpx extracytoplasmic stress response repressor

periplasmic

present

yjaH

b4001

 

-2.32

0.0021

orf, hypothetical protein

 

present

zraP

b4002

 

-3.84

0.0000

zinc binding periplasmic protein, responds to Zn & Pb

periplasm

present

  1. Ave. Fold Change and Average p-value columns are the averaged fold change in gene expression and p-values from the 3 MOPS minimal media functional genomic experiments.
  2. *Gene product located in cytoplasm, but plays a role in membrane component regulation.
  3. Underlined: associated or involved in membrane function, production or regulation.