From: Acceleration of epithelial cell syndecan-1 shedding by anthrax hemolytic virulence factors
Inhibitors | Shed Synd1 (mean % of no-inhibitor control ± C.I.) | ||||
---|---|---|---|---|---|
 | Spontaneous | ClnA | AnlB | AnlO | LT |
No inhibitor | 100 ± 11 | 100 ± 9 | 100 ± 12 | 100 ± 22 | 100 ± 1 |
Tyrphostin A25 | Â | Â | Â | Â | Â |
5 μM 50 μM | 86 ± 6 72 ± 7 | 100 ± 9 | 85 ± 17 | 73 ± 23 67 ± 7 | 97 ± 8 81 ± 4 |
Piceatannol | Â | Â | Â | Â | Â |
0.5 μM 5 μM 50 μM | 191 ± 31 112 ± 24 46 ± 4 | 17 ± 9 | 6 ± 2 | 136 ± 30 88 ± 25 14 ± 9 | 199 ± 15 79 ± 12 25 ± 2 |
Suramin | Â | Â | Â | Â | Â |
20 μM 200 μM | 160 ± 27 36 ± 4 | 89 ± 17 | 118 ± 7 | 155 ± 26 25 ± 4 | 144 ± 14 34 ± 4 |
PD98059 | Â | Â | Â | Â | Â |
5 μM 50 μM | 130 ± 10 133 ± 4 | 103 ± 15 | 88 ± 3 | 84 ± 5 56 ± 5 | 90 ± 4 77 ± 4 |
SB202190 | Â | Â | Â | Â | Â |
5 μM 50 μM | 97 ± 10 91 ± 10 | 108 ± 17 | 101 ± 19 | 72 ± 1 39 ± 1 | 69 ± 4 37 ± 5 |
JNK inhibitor II | Â | Â | Â | Â | Â |
1.5 μM 15 μM | 125 ± 9 145 ± 9 | 92 ± 13 | 129 ± 31 | 89 ± 5 90 ± 5 | 109 ± 7 103 ± 3 |