Table 4 Maximum median concentrations [ppb _v ] with respective time of bacteria growth [h] as well as appearance in exhaled breath of healthy volunteers for selected metabolites which fulfill the criteria for biomarker of Staphylococcus aureus and Pseudomonas aeruginosa (based on in vitro experiments)

2-nonanone

n. s.

-

22.4

28 h

1 h 30 min

0

0

1-nonene

n. s.

-

3.4

26 h

3 h 45 min

0

0

1-decene

n. s.

-

1.2

26 h

5 h 20 min

0

0

1,10-undecadiene

n. s.

-

6.8

24 h

4 h 30 min

0

0

1-dodecene

n. s.

-

9.5

24 h

6 h

0

5,6

1-undecene

n. s.

-

317.5

24 h

1 h 30 min

0

5,6

1-vinylaziridine

n. s.

-

2.8E + 07

2 h 15 min

1 h 30 min

0

0

3-methylpyrrole

n. s.

-

24.74

24 h

5 h 20 min

3,6

0

acetol

331.0

6 h

4 h 30 min

n. s.

-

-

0

0

acetoin

279.3

6 h

1 h 30 min

n. s.

-

-

3,6

0

(E)-2-butene

13.73

6 h

3 h

n. s.

-

-

0

11,1

(Z)-2-butene

4.789

6 h

4 h 30 min

n. s.

-

-

0

5,6

1-butanol

59.40

6 h

4 h 30 min

n. s.

-

-

0

0

ethyl formate

3.188

6 h

6 h

n. s.

-

-

0

0

isopentyl acetate

1.938

6 h

6 h

n. s.

-

-

0

0

ethyl isovalerate

0.852

6 h

6 h

n. s.

-

-

0

0

2-ethylacrolein

6.453

3 h

3 h

n. s.

-

-

0

0

(Z)-2-methyl-2-butenal

268.5

4 h 30 min

3 h

n. s.

-

-

0

0

isovaleric acid

97.35

6 h

4 h 30 min

n. s.

-

-

0

5,6