Figure 1

Percentage of up- and down-regulated genes of L. interrogans serovar Copenhageni in response to serum in each general COG grouping (A) and COG category (B). The percentage of differentially regulated genes was calculated by dividing number of genes up- and down-regulated in each category by the total number of up- and down-regulated genes, respectively × 100. The COG functional categories are as follows: information storage and processing (includes J, translation; A, RNA processing and modification; K, transcription; L, replication, recombination, and repair; B, chromatin structure and dynamics); cellular processes and signaling (includes D, cell cycle control, cell division, chromosome partitioning; Y, Nuclear structure; V, defense mechanisms; T, signal transduction mechanisms; M, cell wall, membrane, or envelope biogenesis; N, cell motility; Z, cytoskeleton; W, extracellular structures; U, intracellular trafficking, secretion, and vesicular trans- port; O, posttranslational modification, protein turnover, chaperones); metabolism (includes C, energy production and conversion; G, carbohydrate transport and metabolism; E, amino acid transport and metabolism; F, nucleotide transport and metabolism; H, coenzyme transport and metabolism; I, lipid transport and metabolism; P, inorganic ion transport and metabolism; Q, secondary metabolite biosynthesis, transport, and catabolism); poorly characterized (includes R, general function prediction only; S, function unknown; and -, not in COGs).