Figure 1From: Virulence regulator AphB enhances toxR transcription in Vibrio choleraeThe ToxR regulon. AphA and AphB are known to activate tcpPH expression. TcpPH and ToxRS activate the expression of ToxT, which in turn activates the expression of the central virulence factors, cholera toxin (CT) and the toxin-coregulated pilus (TCP). ToxRS also upregulates OmpU and downregulates OmpT, which are outer membrane porins.Back to article page