Figure 4

Proteins expressed by type II MAP under iron-replete conditions: Proteins upregulated in cattle MAP strain whereas downregulated in sheep strain in the presence of iron. Fold change for each target is calculated and represented as a ratio of iron-replete/iron-limitation. A negative fold change represents repression and a positive fold change indicates de-repression of that particular target gene in the presence of iron. MhuD = mycobacterial heme utilization, degrader; USP = universal stress protein; CHP = conserved hypothetical protein; MIHF = mycobacterial integration host factor; CsbD = general stress response protein