Skip to main content


Signaling and cellular microbiology

Section edited by Ralf Heermann

This section aims to publish studies looking at all aspects of signaling and cellular microbiology, including cell growth and division, cell cycle, membrane biosynthesis and transport, subcellular organization and ultrastructure, signalling pathways, cell to cell communication, quorum signaling and chemotaxis.

Page 1 of 2

  1. Content type: Research article

    Salmonella enterica serovar Typhimurium is a common food-borne pathogen. S. enterica uses a type III secretion system encoded within Salmonella pathogenicity island 1 (SPI-1) to invade intestinal epithelial cells...

    Authors: Selwan Hamed, Xiaoyi Wang, Riham M. Shawky, Mohamed Emara, Philip D. Aldridge and Christopher V. Rao

    Citation: BMC Microbiology 2019 19:211

    Published on:

  2. Content type: Research article

    Key mechanisms of cell division and its regulation are well understood in model bacteria such as Escherichia coli and Bacillus subtilis. In contrast, current knowledge on the regulation of cell division in Actino...

    Authors: Kim Julia Kraxner, Tino Polen, Meike Baumgart and Michael Bott

    Citation: BMC Microbiology 2019 19:179

    Published on:

  3. Content type: Research article

    Staphylococcus aureus remains a medical challenge in the treatment of bacterial infections. It has acquired resistance to commonly used antibiotics, and to those considered to be the last weapons in treating stap...

    Authors: Ghazal Tajbakhsh and Dasantila Golemi-Kotra

    Citation: BMC Microbiology 2019 19:153

    Published on:

  4. Content type: Research article

    Thermal regulation of gene expression occurs in many microorganisms, and is mediated via several typical mechanisms. Yersinia pestis is the causative agent of the plague and spreads by zoonotic transfer from flea...

    Authors: Abdulmajeed D. Al-Jawdah, Iglika G. Ivanova, Helen Waller, Neil D. Perkins, Jeremy H. Lakey and Daniel T. Peters

    Citation: BMC Microbiology 2019 19:68

    Published on:

  5. Content type: Research article

    Farnesol has potential antifungal activity against Candida albicans biofilms, but the molecular mechanism of this activity is still unclear. Farnesol inhibits hyphal growth by regulating the cyclic AMP (cAMP) sig...

    Authors: Shengyan Chen, Jinping Xia, Chengxi Li, Lulu Zuo and Xin Wei

    Citation: BMC Microbiology 2018 18:203

    Published on:

  6. Content type: Research article

    The pathogenesis of Helicobacter pylori (H. pylori) infection-induced duodenal ulcer remains to be elucidated. Duodenal mucosal bicarbonate secretion is the most important protective factor against acid-induced m...

    Authors: Guorong Wen, Shili Deng, Wenfeng Song, Hai Jin, Jingyu Xu, Xuemei Liu, Rui Xie, Penghong Song and Biguang Tuo

    Citation: BMC Microbiology 2018 18:87

    Published on:

  7. Content type: Research article

    Autoinducer-2 (AI-2) is a universal signal molecule and enables an individual bacteria to communicate with each other and ultimately control behaviors of the population. Harnessing the character of AI-2, two k...

    Authors: Yufen Quan, Fankang Meng, Xinyu Ma, Xinhao Song, Xiao Liu, Weixia Gao, Yulei Dang, Yao Meng, Mingfeng Cao and Cunjiang Song

    Citation: BMC Microbiology 2017 17:198

    Published on:

  8. Content type: Research article

    Chlamydia pneumoniae (C. pneumoniae) is pathogenic to humans, by causing pulmonary inflammation or bronchitis in both adolescents and young adults. However, the molecular signals linki...

    Authors: Hong-liang Chen, Guo-zhi Dai, An-wen Zhou, Ran-hui Li, Hong-xia Yuan, Jing Xiang, Xiao-xing You, Ou Ran and Yi-mou Wu

    Citation: BMC Microbiology 2017 17:153

    Published on:

  9. Content type: Research article

    Hepatitis C virus (HCV) core protein and nonstructural protein 4B (NS4B) are potentially oncogenic. Aberrant activation of the Wnt/β-catenin signaling pathway is closely associated with hepatocarcinogenesis. W...

    Authors: Xiao-Hua Jiang, Yu-Tao Xie, Ya-Ping Cai, Jing Ren and Tao Ma

    Citation: BMC Microbiology 2017 17:124

    Published on:

  10. Content type: Research article

    The secondary messenger cyclic di-GMP promotes biofilm formation by up regulating the expression of csgD, encoding the major regulator of rdar biofilm formation in Salmonella typhimurium. The GGDEF/EAL domain pro...

    Authors: Irfan Ahmad, Annika Cimdins, Timo Beske and Ute Römling

    Citation: BMC Microbiology 2017 17:27

    Published on:

  11. Content type: Research article

    Reversible protein phosphorylation catalyzed by protein kinases and phosphatases is the primary mechanism for signal transduction in all living organisms. Streptococcus pneumoniae encodes a single Ser/Thr protein...

    Authors: Aleš Ulrych, Nela Holečková, Jana Goldová, Linda Doubravová, Oldřich Benada, Olga Kofroňová, Petr Halada and Pavel Branny

    Citation: BMC Microbiology 2016 16:247

    Published on:

  12. Content type: Research article

    Traditional medicinal plants have been used as an alternative medicine in many parts of the world, including Ethiopia. There are many documented scientific reports on antimicrobial activities of the same. To o...

    Authors: Ketema Bacha, Yinebeb Tariku, Fisseha Gebreyesus, Shibru Zerihun, Ali Mohammed, Nancy Weiland-Bräuer, Ruth A. Schmitz and Mulugeta Mulat

    Citation: BMC Microbiology 2016 16:139

    Published on:

  13. Content type: Research article

    Tissue factor pathway inhibitor-2 (TFPI-2) is a serine protease inhibitor that exerts multiple physiological and patho-physiological activities involving the modulation of coagulation, angiogenesis, tumor inva...

    Authors: Gopinath Kasetty, Emanuel Smeds, Emelie Holmberg, Louise Wrange, Selvi Adikesavan and Praveen Papareddy

    Citation: BMC Microbiology 2016 16:129

    Published on:

  14. Content type: Research article

    Different species and strains of probiotic bacteria confer distinct immunological responses on immune cells. Lactobacillus rhamnosus GR-1 (GR-1) is a probiotic bacterial strain found in both the intestinal and ur...

    Authors: Shahab Meshkibaf, Jӧrg Fritz, Marcelo Gottschalk and Sung Ouk Kim

    Citation: BMC Microbiology 2015 15:238

    Published on:

  15. Content type: Research article

    The signaling second messenger cyclic AMP (cAMP) regulates many aspects of cellular function in all organisms. Previous studies have suggested a role for cAMP in the regulation of gene expression of cellulolyt...

    Authors: Karoline Maria Vieira Nogueira, Mariana do Nascimento Costa, Renato Graciano de Paula, Flávia Costa Mendonça-Natividade, Rafael Ricci-Azevedo and Roberto Nascimento Silva

    Citation: BMC Microbiology 2015 15:195

    Published on:

  16. Content type: Research article

    Pseudomonas aeruginosa is an opportunistic pathogen that is the leading cause of iatrogenic infections in critically ill patients, especially those undergoing mechanical ventilation. I...

    Authors: Hongdong Li, Xingyuan Li, Zhengli Wang, Yakun Fu, Qing Ai, Ying Dong and Jialin Yu

    Citation: BMC Microbiology 2015 15:192

    Published on:

  17. Content type: Methodology article

    The cyclic diguanylate (c-di-GMP) is currently considered an ubiquitous second messenger in bacteria that influences a wide range of cellular processes. One of the methodological approaches to unravel c-di-GMP...

    Authors: Lorena Romero-Jiménez, David Rodríguez-Carbonell, María Trinidad Gallegos, Juan Sanjuán and Daniel Pérez-Mendoza

    Citation: BMC Microbiology 2015 15:190

    Published on:

  18. Content type: Research article

    The Escherichia coli response regulator NarL controls transcription of genes involved in nitrate respiration during anaerobiosis. NarL consists of two domains joined by a linker that wraps around the interdomain ...

    Authors: Galit Katsir, Michael Jarvis, Martin Phillips, Zhongcai Ma and Robert P. Gunsalus

    Citation: BMC Microbiology 2015 15:174

    Published on:

  19. Content type: Research article

    Motility of flagellated bacteria depends crucially on their organelles such as flagella and pili, as well as physical properties of the external medium, such as viscosity and matrix elasticity. We studied the ...

    Authors: Yukun Gao, Marianna Neubauer, Alexander Yang, Nathan Johnson, Michael Morse, Guanglai Li and Jay X Tang

    Citation: BMC Microbiology 2014 14:322

    Published on:

  20. Content type: Research article

    Bacillus thuringiensis GabR is a Sigma 54-dependent transcriptional activator containing three typical domains, an N-terminal regulatory domain Per-ARNT-Sim (PAS), a central AAA+ (ATPases associated with differe...

    Authors: Qi Peng, Min Yang, Wei Wang, Lili Han, Guannan Wang, Pengyue Wang, Jie Zhang and Fuping Song

    Citation: BMC Microbiology 2014 14:306

    Published on:

  21. Content type: Research article

    Curcumin (CUR), an active polyphenol derived from the spice turmeric, has been traditionally used for centuries in ancient Indian medicine to treat a number of diseases. The physiological effects of CUR have b...

    Authors: Gajendra Kumar Azad, Vikash Singh, Mayur Jankiram Thakare, Shivani Baranwal and Raghuvir Singh Tomar

    Citation: BMC Microbiology 2014 14:317

    Published on:

  22. Content type: Research article

    Bacteria often form multicellular, organized communities known as biofilms, which protect cells from a variety of environmental stresses. During biofilm formation, bacteria secrete a species-specific matrix; in B...

    Authors: Sara A Leiman, Laura C Arboleda, Joseph S Spina and Anna L McLoon

    Citation: BMC Microbiology 2014 14:301

    Published on:

  23. Content type: Research article

    Synthesis and uptake of pyoverdine, the primary siderophore of the opportunistic pathogen Pseudomonas aeruginosa, is dependent on two extra-cytoplasmic function (ECF) sigma factors, FpvI and PvdS. FpvI and PvdS a...

    Authors: Rebecca J Edgar, Xin Xu, Matt Shirley, Anna F Konings, Lois W Martin, David F Ackerley and Iain L Lamont

    Citation: BMC Microbiology 2014 14:287

    Published on:

  24. Content type: Research article

    Aquatic biofilms often serve as environmental reservoirs for microorganisms and provide them with a nutrient-rich growth environment under harsh conditions. With regard to Cryptosporidium, biofilms can serve as e...

    Authors: Wan Koh, Andrew Thompson, Hanna Edwards, Paul Monis and Peta L Clode

    Citation: BMC Microbiology 2014 14:281

    Published on:

  25. Content type: Research article

    The second messenger cyclic diguanylate (c-di-GMP) plays a central role in bacterial adaptation to extracellular stimuli, controlling processes such as motility, biofilm development, cell development and, in s...

    Authors: Robert W McKee, Ankunda Kariisa, Benjamin Mudrak, Courtney Whitaker and Rita Tamayo

    Citation: BMC Microbiology 2014 14:272

    Published on:

  26. Content type: Research article

    Pectinex Ultra SP-L (Pectinex) is a microbial-derived enzyme that is used in the food industry and that has been shown to inhibit bacterial biofilms. It has been suggested that Pectinex may be useful in the ma...

    Authors: Ian P Olwoch, Oppel B W Greeff, Gisela Jooné and Vanessa Steenkamp

    Citation: BMC Microbiology 2014 14:251

    Published on:

  27. Content type: Methodology article

    Bacterial biofilms are predominant in natural ecosystems and constitute a public health threat because of their outstanding resistance to antibacterial treatments and especially to antibiotics. To date, severa...

    Authors: Marc Crouzet, Caroline Le Senechal, Volker S Brözel, Patricia Costaglioli, Christophe Barthe, Marc Bonneu, Bertrand Garbay and Sebastien Vilain

    Citation: BMC Microbiology 2014 14:253

    Published on:

  28. Content type: Research article

    The treatment of leishmaniasis with pentavalent antimonials is problematic because of their toxicity. Investigations of potentially active molecules are important to discover less toxic drugs that are viable e...

    Authors: Elizandra Aparecida Britta, Débora Botura Scariot, Hugo Falzirolli, Tânia Ueda-Nakamura, Cleuza Conceição Silva, Benedito Prado Dias Filho, Redouane Borsali and Celso Vataru Nakamura

    Citation: BMC Microbiology 2014 14:236

    Published on:

  29. Content type: Research article

    Porphyromonas gingivalis is an important bacterial etiological agent involved in periodontitis. The bacterium expresses two kinds of cysteine proteases called gingipains: arginine gingipains (RgpA/B) and lysine ...

    Authors: Kartheyaene Jayaprakash, Hazem Khalaf and Torbjörn Bengtsson

    Citation: BMC Microbiology 2014 14:193

    Published on:

  30. Content type: Research article

    Meiotic cells undergo two rounds of nuclear division and generate gametes. Previous studies have indicated that a number of transcription factors modulate the transcriptome in successive waves during meiosis a...

    Authors: Naoyuki Togashi, Akira Yamashita, Masamitsu Sato and Masayuki Yamamoto

    Citation: BMC Microbiology 2014 14:188

    Published on:

  31. Content type: Research article

    The ColRS two-component system has been shown to contribute to the membrane functionality and stress tolerance of Pseudomonas putida as well as to the virulence of Pseudomonas aeruginosa and plant pathogenic Xant...

    Authors: Kadi Ainsaar, Karl Mumm, Heili Ilves and Rita Hõrak

    Citation: BMC Microbiology 2014 14:162

    Published on:

  32. Content type: Research article

    Production of the gene transfer agent RcGTA in the α-proteobacterium Rhodobacter capsulatus is dependent upon the response regulator protein CtrA. Loss of this regulator has widespread effects on transcription in...

    Authors: Ryan G Mercer and Andrew S Lang

    Citation: BMC Microbiology 2014 14:71

    Published on:

  33. Content type: Research article

    Acinetobacter baumannii has emerged as an opportunistic nosocomial pathogen causing infections worldwide. One reason for this emergence is due to its natural ability to survive in the hospital environment, which...

    Authors: Yassine Nait Chabane, Mohamed Ben Mlouka, Stéphane Alexandre, Marion Nicol, Sara Marti, Martine Pestel-Caron, Jordi Vila, Thierry Jouenne and Emmanuelle Dé

    Citation: BMC Microbiology 2014 14:62

    Published on:

  34. Content type: Research article

    Extensive use of antibiotics has fostered the emergence of superbugs that are resistant to multidrugs, which becomes a great healthcare and public concern. Previous studies showed that quorum sensing signal DS...

    Authors: Yinyue Deng, Amy Lim, Jasmine Lee, Shaohua Chen, Shuwen An, Yi-Hu Dong and Lian-Hui Zhang

    Citation: BMC Microbiology 2014 14:51

    Published on:

  35. Content type: Research article

    Diguanylate cyclases (DGCs) regulate biofilm formation and motility in bacteria by synthesizing the second messenger cyclic di-GMP (c-di-GMP) in response to environmental stimuli. DGC enzymatic activity is bel...

    Authors: Jessica L Hunter, Geoffrey B Severin, Benjamin J Koestler and Christopher M Waters

    Citation: BMC Microbiology 2014 14:22

    Published on:

  36. Content type: Research article

    Celiac disease is characterized by enhanced intestinal paracellular permeability due to alterations of function and expression of tight junction (TJ) proteins including ZO-1, Claudin-1 and Occludin. Polyamines...

    Authors: Antonella Orlando, Michele Linsalata, Maria Notarnicola, Valeria Tutino and Francesco Russo

    Citation: BMC Microbiology 2014 14:19

    Published on:

  37. Content type: Research article

    The Escherichia coli uropathogenic-specific protein (Usp) is a bacteriocin-like genotoxin, active against mammalian cells and associated with E. coli strains that provoke pyelonephritis, prostatitis and bacteraem...

    Authors: Miha Črnigoj, Zdravko Podlesek, Maruška Budič and Darja Žgur-Bertok

    Citation: BMC Microbiology 2014 14:16

    Published on:

  38. Content type: Research article

    Antimicrobial peptides have been the focus of much research over the last decade because of their effectiveness and broad-spectrum activity against microbial pathogens. These peptides also participate in infla...

    Authors: Simon Theberge, Abdelhabib Semlali, Abdullah Alamri, Kai P Leung and Mahmoud Rouabhia

    Citation: BMC Microbiology 2013 13:246

    Published on:

  39. Content type: Research article

    Cis-2-dodecenoic acid (BDSF) is well known for its important functions in intraspecies signaling in Burkholderia cenocepacia. Previous work has also established an important role of BDSF in interspecies and inter...

    Authors: Yinyue Deng, Calvin Boon, Shaohua Chen, Amy Lim and Lian-Hui Zhang

    Citation: BMC Microbiology 2013 13:231

    Published on:

  40. Content type: Research article

    Microorganisms use two-component signal transduction (TCST) systems to regulate the response of the organism to changes of environmental conditions. Such systems are absent from mammalian cells and are thus of...

    Authors: Mohammed El-Mowafy, Mahmoud M Bahgat and Ursula Bilitewski

    Citation: BMC Microbiology 2013 13:209

    Published on:

  41. Content type: Research article

    The facultative anoxygenic photosynthetic bacterium Rhodospirillum rubrum exhibits versatile metabolic activity allowing the adaptation to rapidly changing growth conditions in its natural habitat, the microaerob...

    Authors: Lisa Carius, Anke B Carius, Matthew McIntosh and Hartmut Grammel

    Citation: BMC Microbiology 2013 13:189

    Published on:

  42. Content type: Research article

    The developmental cycle of the obligate intracellular pathogen Chlamydia is dependant on the formation of a unique intracellular niche termed the chlamydial inclusion. The inclusion is a membrane bound vacuole de...

    Authors: Theresa S Richards, Andrea E Knowlton and Scott S Grieshaber

    Citation: BMC Microbiology 2013 13:185

    Published on:

  43. Content type: Research article

    Biofilms are communities of bacteria that are characterized by specific phenotypes, including an increased resistance towards anti-microbials and the host immune system. This calls for the development of novel...

    Authors: Priyankar Samanta, Emily R Clark, Katie Knutson, Shelley M Horne and Birgit M Prüß

    Citation: BMC Microbiology 2013 13:182

    Published on:

  44. Content type: Research article

    The emergence of colony morphology variants in structured environments is being recognized as important to both niche specialization and stress tolerance. Pseudomonas fluorescens demonstrates diversity in both it...

    Authors: Matthew L Workentine, Siyuan Wang, Howard Ceri and Raymond J Turner

    Citation: BMC Microbiology 2013 13:175

    Published on:

  45. Content type: Research article

    Success of biofilm dwelling bacteria in causing persistent and chronic infections is attributed to their resistance towards antibiotics and immune defences. Free iron is critical for the growth of biofilm asso...

    Authors: Sanjay Chhibber, Deepika Nag and Shruti Bansal

    Citation: BMC Microbiology 2013 13:174

    Published on:

  46. Content type: Research article

    Microcalorimetric bacterial growth studies have illustrated that thermograms differ significantly with both culture media and strain. The present contribution examines the possibility of discriminating between...

    Authors: Dragos C Zaharia, Alexandru A Muntean, Mihnea G Popa, Alexandru T Steriade, Octavian Balint, Roxana Micut, Corneliu Iftene, Ioana Tofolean, Vlad T Popa, Cristian Baicus, Miron A Bogdan and Mircea I Popa

    Citation: BMC Microbiology 2013 13:171

    Published on:

  47. Content type: Research article

    Polar development during the alphaproteobacterium Caulobacter crescentus cell cycle is integrated to the point that individual mutations can have pleiotropic effects on the synthesis of polar organelles. Disrupti...

    Authors: Patrick D Curtis, David Klein and Yves V Brun

    Citation: BMC Microbiology 2013 13:166

    Published on: