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Microbial biochemistry, physiology and metabolism

This section aims to publish studies relating to microbial biochemistry, physiology and metabolism, including enzymology, metabolic pathways and regulation, growth, development and stress responses.

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  1. Aflatoxins (AFs) are potent carcinogenic compounds produced by several Aspergillus species, which pose serious threats to human health. As sugar is a preferred carbohydrate source for AF production, we examined t...

    Authors: Jin-Dan Zhang, Lida Han, Shijuan Yan and Chun-Ming Liu

    Citation: BMC Microbiology 2014 14:95

    Content type: Research article

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  2. The disaccharide trehalose is a major component of fungal spores and is released upon germination. Moreover, the sugar is well known for is protective functions, e.g. against thermal stress and dehydration. Th...

    Authors: Åsa Svanström, Martin Richard van Leeuwen, Jan Dijksterhuis and Petter Melin

    Citation: BMC Microbiology 2014 14:90

    Content type: Research article

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  3. The currently accepted thesis on nitrogenous fertilizer additions on methane oxidation activity assumes niche partitioning among methanotrophic species, with activity responses to changes in nitrogen content b...

    Authors: Sven Hoefman, David van der Ha, Nico Boon, Peter Vandamme, Paul De Vos and Kim Heylen

    Citation: BMC Microbiology 2014 14:83

    Content type: Research article

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  4. Metal tolerance in bacteria has been related to polyP in a model in which heavy metals stimulate the polymer hydrolysis, forming metal-phosphate complexes that are exported. As previously described in our labo...

    Authors: Mariana Grillo-Puertas, Lici Ariane Schurig-Briccio, Luisa Rodríguez-Montelongo, María Regina Rintoul and Viviana Andrea Rapisarda

    Citation: BMC Microbiology 2014 14:72

    Content type: Research article

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  5. Corynebacterium glutamicum cg1790/pgk encodes an enzyme active as a 3-phosphoglycerate kinase (PGK) (EC 2.7.2.3) catalyzing phosphoryl transfer from 1,3-biphosphoglycerate (bPG) to ADP to yield 3-phosphoglycerat...

    Authors: Gajendar Komati Reddy and Volker F Wendisch

    Citation: BMC Microbiology 2014 14:54

    Content type: Research article

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  6. Haemophilus influenzae colonizes the nasopharynx as a commensal. Strain-specific factors allow some strains to migrate to particular anatomical niches, such as the middle ear, bronchi or blood, and induce diseas...

    Authors: Nadiah Ishak, Alexandra Tikhomirova, Stephen J Bent, Garth D Ehrlich, Fen Z Hu and Stephen P Kidd

    Citation: BMC Microbiology 2014 14:47

    Content type: Research article

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  7. Laribacter hongkongensis is a Gram-negative, urease-positive bacillus associated with invasive bacteremic infections in liver cirrhosis patients and fish-borne community-acquired gastroenteritis and traveler’s d...

    Authors: Lifeng Xiong, Jade LL Teng, Rory M Watt, Biao Kan, Susanna KP Lau and Patrick CY Woo

    Citation: BMC Microbiology 2014 14:42

    Content type: Research article

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  8. A wealth of microbial eukaryotes is adapted to life in oxygen-deficient marine environments. Evidence is accumulating that some of these eukaryotes survive anoxia by employing dissimilatory nitrate reduction, ...

    Authors: Peter Stief, Silvia Fuchs-Ocklenburg, Anja Kamp, Cathrine-Sumathi Manohar, Jos Houbraken, Teun Boekhout, Dirk de Beer and Thorsten Stoeck

    Citation: BMC Microbiology 2014 14:35

    Content type: Research article

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  9. In this study we employed the TAP tag purification method coupled with mass spectrometry analysis to identify proteins that co-purify with Escherichia coli RNase R during exponential growth and after temperature ...

    Authors: Michal Malecki, Cátia Bárria and Cecilia M Arraiano

    Citation: BMC Microbiology 2014 14:34

    Content type: Research article

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  10. In an effort to reconstitute the NAD+ synthetic pathway in Escherichia coli (E. coli), we produced a set of gene knockout mutants with deficiencies in previously well-defined NAD+ de novo and salvage pathways. Un...

    Authors: Wei-Ren Dong, Cen-Cen Sun, Guan Zhu, Shi-Hua Hu, Li-Xin Xiang and Jian-Zhong Shao

    Citation: BMC Microbiology 2014 14:29

    Content type: Research article

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  11. Lactobacillus rhamnosus is a non-starter lactic acid bacterium that plays a significant role during cheese ripening, leading to the formation of flavor. In long-ripened cheeses it persists throughout the whole t...

    Authors: Camilla Lazzi, Silvia Turroni, Andrea Mancini, Elisa Sgarbi, Erasmo Neviani, Patrizia Brigidi and Monica Gatti

    Citation: BMC Microbiology 2014 14:28

    Content type: Research article

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  12. Multidrug efflux pumps are membrane translocases that have the ability to extrude a variety of structurally unrelated compounds from the cell. AcrD, a resistance-nodulation-cell division (RND) transporter, was...

    Authors: Daniel Pletzer and Helge Weingart

    Citation: BMC Microbiology 2014 14:13

    Content type: Research article

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  13. Penicillin-resistance in Streptococcus pneumoniae is mainly due to alterations in genes encoding the target enzymes for beta-lactams, the penicillin-binding proteins (PBPs). However, non-PBP genes are altered in ...

    Authors: Marina Meiers, Carsten Volz, Jessica Eisel, Patrick Maurer, Bernhard Henrich and Regine Hakenbeck

    Citation: BMC Microbiology 2014 14:12

    Content type: Research article

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  14. Transketolase (TKT) is a key enzyme of the pentose phosphate pathway (PPP), the Calvin cycle and the ribulose monophosphate (RuMP) cycle. Bacillus methanolicus is a facultative RuMP pathway methylotroph. B. metha...

    Authors: Benno Markert, Jessica Stolzenberger, Trygve Brautaset and Volker F Wendisch

    Citation: BMC Microbiology 2014 14:7

    Content type: Research article

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  15. Adenosine triphosphate (ATP) is used as an intracellular energy source by all living organisms. It plays a central role in the respiration and metabolism, and is the most important energy supplier in many enzy...

    Authors: Roberto Mempin, Helen Tran, Connie Chen, Hao Gong, Katharina Kim Ho and Sangwei Lu

    Citation: BMC Microbiology 2013 13:301

    Content type: Research article

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  16. Lysine plays an important role in Streptomyces clavuligerus metabolism; it takes part in its catabolism, via cadaverine, and in its secondary metabolism, in which lysine is converted via 1-piperideine-6-carboxyla...

    Authors: Carla A Leite, André P Cavallieri and Maria L G C Araujo

    Citation: BMC Microbiology 2013 13:296

    Content type: Research article

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  17. Functional characterization of genes in important pathogenic bacteria such as Mycobacterium tuberculosis is imperative. Rv2135c, which was originally annotated as conserved hypothetical, has been found to be asso...

    Authors: Olabisi Oluwabukola Coker, Saradee Warit, Kamolchanok Rukseree, Pijug Summpunn, Therdsak Prammananan and Prasit Palittapongarnpim

    Citation: BMC Microbiology 2013 13:292

    Content type: Research article

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  18. Bradyrhizobium japonicum USDA110, a soybean symbiont, is capable of accumulating a large amount of poly-β-hydroxybutyrate (PHB) as an intracellular carbon storage polymer during free-living growth. Within the gen...

    Authors: Ken-ichi Yoshida, Yuki Takemoto, Takayuki Sotsuka, Kosei Tanaka and Shinji Takenaka

    Citation: BMC Microbiology 2013 13:290

    Content type: Research article

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  19. Stachybotrys chartarum is a filamentous mold frequently identified among the mycobiota of water-damaged building materials. Growth of S. chartarum on suitable substrates and under favorable environmental conditio...

    Authors: Doris A Betancourt, Ken Krebs, Scott A Moore and Shayna M Martin

    Citation: BMC Microbiology 2013 13:283

    Content type: Research article

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  20. Bovine papillomatous digital dermatitis (DD) is the leading cause of lameness in dairy cattle and represents a serious welfare and economic burden. Found primarily in high production dairy cattle worldwide, DD...

    Authors: Jennifer H Wilson-Welder, Margaret K Elliott, Richard L Zuerner, Darrell O Bayles, David P Alt and Thad B Stanton

    Citation: BMC Microbiology 2013 13:280

    Content type: Research article

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  21. XylS is the positive regulator of the inducible Pm promoter, originating from Pseudomonas putida, where the system controls a biochemical pathway involved in degradation of aromatic hydrocarbons, which also act a...

    Authors: Friederike Zwick, Rahmi Lale and Svein Valla

    Citation: BMC Microbiology 2013 13:262

    Content type: Research article

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  22. The balanced synthesis of membrane phospholipids, fatty acids and cell wall constituents is a vital facet of bacterial physiology, but there is little known about the biochemical control points that coordinate...

    Authors: Joshua B Parsons, Jiangwei Yao, Pamela Jackson, Matthew Frank and Charles O Rock

    Citation: BMC Microbiology 2013 13:260

    Content type: Research article

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  23. In this study, we aimed at investigating heterogeneity in the expression of metabolic genes in clonal populations of Escherichia coli growing on glucose as the sole carbon source. Different metabolic phenotypes c...

    Authors: Nela Nikolic, Thomas Barner and Martin Ackermann

    Citation: BMC Microbiology 2013 13:258

    Content type: Research article

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  24. Abundant populations of bacteria have been observed on Mir and the International Space Station. While some experiments have shown that bacteria cultured during spaceflight exhibit a range of potentially troubl...

    Authors: Wooseong Kim, Farah K Tengra, Jasmine Shong, Nicholas Marchand, Hon Kit Chan, Zachary Young, Ravindra C Pangule, Macarena Parra, Jonathan S Dordick, Joel L Plawsky and Cynthia H Collins

    Citation: BMC Microbiology 2013 13:241

    Content type: Research article

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  25. Lipoproteins are virulence factors of Mycobacterium tuberculosis. Bacterial lipoproteins are modified by the consecutive action of preprolipoprotein diacylglyceryl transferase (Lgt), prolipoprotein signal peptida...

    Authors: Juliane K Brülle, Andreas Tschumi and Peter Sander

    Citation: BMC Microbiology 2013 13:223

    Content type: Research article

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  26. Magnetotactic bacteria produce membrane-enveloped magnetite crystals (magnetosomes) whose formation is controlled primarily by a gene island termed the magnetosome island (MAI). Characterization of single gene...

    Authors: Jing Yang, Shuqi Li, Xiuliang Huang, Jinhua Li, Li Li, Yongxin Pan and Ying Li

    Citation: BMC Microbiology 2013 13:203

    Content type: Research article

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  27. Naphthoquinones (NQs) are privileged structures in medicinal chemistry due to the biological effects associated with the induction of oxidative stress. The present study evaluated the activities of sixteen NQs...

    Authors: Kelly Salomão, Natalia A De Santana, Maria Teresa Molina, Solange L De Castro and Rubem F S Menna-Barreto

    Citation: BMC Microbiology 2013 13:196

    Content type: Research article

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  28. The increase in antibiotic resistant bacteria has led to renewed interest in development of alternative antimicrobial compounds such as antimicrobial peptides (AMPs), either naturally-occurring or syntheticall...

    Authors: Sanne Gottschalk, Dan Ifrah, Sandra Lerche, Caroline T Gottlieb, Marianne T Cohn, Hiroshi Hiasa, Paul R Hansen, Lone Gram, Hanne Ingmer and Line E Thomsen

    Citation: BMC Microbiology 2013 13:192

    Content type: Research article

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  29. The growth of Escherichia coli at elevated temperatures is limited due to the inherent instability of homoserine o-succinyltransferase, MetA, which is the first enzyme in the methionine biosynthesis pathway. MetA...

    Authors: Elena A Mordukhova, Dooil Kim and Jae-Gu Pan

    Citation: BMC Microbiology 2013 13:179

    Content type: Research article

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  30. In bacteria, signal-transduction two-component systems are major players for adaptation to environmental stimuli. The perception of a chemical or physical signal by a sensor-kinase triggers its autophosphoryla...

    Authors: Elian Dupré, Alexandre Wohlkonig, Julien Herrou, Camille Locht, Françoise Jacob-Dubuisson and Rudy Antoine

    Citation: BMC Microbiology 2013 13:172

    Content type: Research article

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  31. As an opportunistic human pathogen Pseudomonas aeruginosa is able to cause acute and chronic infections. The biofilm mode of life significantly contributes to the growth and persistence of P. aeruginosa during an...

    Authors: Petra Tielen, Hubert Kuhn, Frank Rosenau, Karl-Erich Jaeger, Hans-Curt Flemming and Jost Wingender

    Citation: BMC Microbiology 2013 13:159

    Content type: Research article

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  32. S. oneidensis MR-1 is a dissimilatory metal-reducing bacterium. Under anoxic conditions S. oneidensis MR-1 attaches to and uses insoluble minerals such as Fe(III) and Mn(IV) oxides as electron acceptors. In the l...

    Authors: Jana Müller, Soni Shukla, Kathinka A Jost and Alfred M Spormann

    Citation: BMC Microbiology 2013 13:119

    Content type: Research article

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  33. Populations of aerobic anoxygenic photoheterotrophic bacteria in marine environments are dominated by members of the Roseobacter lineage within the Alphaproteobacteria and the OM60/NOR5 clade of gammaproteobacter...

    Authors: Stefan Spring and Thomas Riedel

    Citation: BMC Microbiology 2013 13:117

    Content type: Research article

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  34. Pseudomonas fluorescens SBW25 has been extensively studied because of its plant growth promoting properties and potential as a biocontrol agent. The genome of SBW25 has been sequenced, and among sequenced strains...

    Authors: Kristin Trippe, Kerry McPhail, Donald Armstrong, Mark Azevedo and Gary Banowetz

    Citation: BMC Microbiology 2013 13:111

    Content type: Research article

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    The Erratum to this article has been published in BMC Microbiology 2013 13:263

  35. The fungus Paracoccidioides spp is the agent of paracoccidioidomycosis (PCM), a pulmonary mycosis acquired by the inhalation of fungal propagules. Paracoccidioides malate synthase (PbMLS) is important in the infe...

    Authors: Karine Martins de Oliveira, Benedito Rodrigues da Silva Neto, Juliana Alves Parente, Roosevelt Alves da Silva, Guilherme Oliveira Quintino, Aline Raquel Voltan, Maria José Soares Mendes-Giannini, Célia Maria de Almeida Soares and Maristela Pereira

    Citation: BMC Microbiology 2013 13:107

    Content type: Research article

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  36. Arginine methylation is a post-translational modification that expands the functional diversity of proteins. Kinetoplastid parasites contain a relatively large group of protein arginine methyltransferases (PRM...

    Authors: Michel Pelletier, Alyssa S Frainier, Dominic N Munini, Jenna M Wiemer, Amber R Karpie and Jeff J Sattora

    Citation: BMC Microbiology 2013 13:101

    Content type: Research article

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  37. The ATP-Binding Cassette (ABC) functional superfamily includes integral transmembrane exporters that have evolved three times independently, forming three families termed ABC1, ABC2 and ABC3, upon which monoph...

    Authors: Wei Hao Zheng, Åke Västermark, Maksim A Shlykov, Vamsee Reddy, Eric I Sun and Milton H Saier

    Citation: BMC Microbiology 2013 13:98

    Content type: Research article

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  38. The catabolic pathways of N-acetyl-D-galactosamine (Aga) and D-galactosamine (Gam) in E. coli were proposed from bioinformatic analysis of the aga/gam regulon in E. coli K-12 and later from studies using E. coli ...

    Authors: Zonglin Hu, Isha R Patel and Amit Mukherjee

    Citation: BMC Microbiology 2013 13:94

    Content type: Research article

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    The Erratum to this article has been published in BMC Microbiology 2014 14:127

  39. Heavy metal Resistance-Nodulation-Division (HME-RND) efflux systems help Gram-negative bacteria to keep the intracellular homeostasis under high metal concentrations. These proteins constitute the cytoplasmic ...

    Authors: Estela Y Valencia, Vânia S Braz, Cristiane Guzzo and Marilis V Marques

    Citation: BMC Microbiology 2013 13:79

    Content type: Research article

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  40. The ability to distinguish nonself from self is a fundamental characteristic of biological systems. In the filamentous fungus Neurospora crassa, multiple incompatibility genes mediate nonself recognition during v...

    Authors: Robert Phillip Smith, Kenji Wellman and Myron L Smith

    Citation: BMC Microbiology 2013 13:63

    Content type: Research article

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  41. The cellular temperatures of microorganisms are considered to be the same as those of their surroundings because the cellular volume is too small to maintain a cellular temperature that is different from the a...

    Authors: Kenji Tabata, Fuminori Hida, Tomoyuki Kiriyama, Noriaki Ishizaki, Toshiaki Kamachi and Ichiro Okura

    Citation: BMC Microbiology 2013 13:56

    Content type: Research article

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  42. Hfq is an RNA chaperone protein that has been broadly implicated in sRNA function in bacteria. Here we describe the construction and characterization of a null allele of the gene that encodes the RNA chaperone...

    Authors: Christopher M Brennan, Meghan L Keane, Taylor M Hunt, Matthew T Goulet, Nicholas Q Mazzucca, Zachary Sexton, Taylor Mezoian, Katherine E Douglas, Jessica M Osborn and Brett J Pellock

    Citation: BMC Microbiology 2013 13:33

    Content type: Research article

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  43. The Staphylococcus aureus RecU protein is homologous to a Bacillus subtilis Holliday junction resolvase. Interestingly, RecU is encoded in the same operon as PBP2, a penicillin-binding protein required for cell w...

    Authors: Ana R Pereira, Patricia Reed, Helena Veiga and Mariana G Pinho

    Citation: BMC Microbiology 2013 13:18

    Content type: Research article

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    The Erratum to this article has been published in BMC Microbiology 2017 17:119

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