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Microbial biochemistry, physiology and metabolism

This section aims to publish studies relating to microbial biochemistry, physiology and metabolism, including enzymology, metabolic pathways and regulation, growth, development and stress responses.

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  1. Streptococcus pneumoniae is one of the leading causes of community acquired pneumonia and acute otitis media. Certain aspects of S. pneumoniae’s virulence are dependent upon expression...

    Authors: Joseph C. Bryant, Ridge C. Dabbs, Katie L. Oswalt, Lindsey R. Brown, Jason W. Rosch, Keun S. Seo, Janet R. Donaldson, Larry S. McDaniel and Justin A. Thornton

    Citation: BMC Microbiology 2016 16:271

    Content type: Research article

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  2. In Escherichia coli, nagD, yrfG, yjjG, yieH, yigL, surE, and yfbR encode 5′-nucleotidases that hydrolyze the phosphate group of 5′-nucleotides. In Bacillus subtilis, genes encoding 5′-nucleotidase have remained t...

    Authors: Ayako Terakawa, Ayane Natsume, Atsushi Okada, Shogo Nishihata, Junko Kuse, Kosei Tanaka, Shinji Takenaka, Shu Ishikawa and Ken-ichi Yoshida

    Citation: BMC Microbiology 2016 16:249

    Content type: Research article

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  3. Human milk oligosaccharides (HMOs) are one of the major glycan source of the infant gut microbiota. The two species that predominate the infant bifidobacteria community, Bifidobacterium longum subsp. infantis and...

    Authors: Vera Bunesova, Christophe Lacroix and Clarissa Schwab

    Citation: BMC Microbiology 2016 16:248

    Content type: Research article

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  4. Proteins from the LytR-CpsA-Psr family are found in almost all Gram-positive bacteria. Although LCP proteins have been studied in other pathogens, their functions in enterococci remain uncharacterized. The Psr...

    Authors: Maxime Maréchal, Ana Amoroso, Cécile Morlot, Thierry Vernet, Jacques Coyette and Bernard Joris

    Citation: BMC Microbiology 2016 16:239

    Content type: Research article

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  5. Community and nosocomial infections by Pseudomonas aeruginosa still create a major therapeutic challenge. The resistance of this opportunist pathogen to β-lactam antibiotics is determined mainly by production of ...

    Authors: Cristian Gustavo Aguilera Rossi, Paulino Gómez-Puertas and Juan Alfonso Ayala Serrano

    Citation: BMC Microbiology 2016 16:234

    Content type: Research article

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  6. Cyclodipeptides and their derivatives constitute a large class of peptide natural products with noteworthy biological activities. In some yeasts and bacterial species, pulcherriminic acid derived from cyclo-L-...

    Authors: Paola Randazzo, Anne Aubert-Frambourg, Alain Guillot and Sandrine Auger

    Citation: BMC Microbiology 2016 16:190

    Content type: Research article

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  7. In Gram-positive Corynebacterium glutamicum and other members of the suborder Corynebacterianeae, which includes mycobacteria, cell elongation and peptidoglycan biosynthesis is mainly due to polar growth. C. glut...

    Authors: Christian Matano, Stephan Kolkenbrock, Stefanie N. Hamer, Elvira Sgobba, Bruno M. Moerschbacher and Volker F. Wendisch

    Citation: BMC Microbiology 2016 16:177

    Content type: Research article

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  8. Malic enzymes decarboxylate the tricarboxylic acid (TCA) cycle intermediate malate to the glycolytic end-product pyruvate and are well positioned to regulate metabolic flux in central carbon metabolism. Despit...

    Authors: Ye Zhang, Laura Anne Smallbone, George C. diCenzo, Richard Morton and Turlough M. Finan

    Citation: BMC Microbiology 2016 16:163

    Content type: Research article

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  9. Two variants of Methylobacterium extorquens AM1 demonstrated a trade-off between growth rate and biomass yield. In addition, growth rate and biomass yield were also affected by supplementation of growth medium wi...

    Authors: Yanfen Fu, David A. C. Beck and Mary E. Lidstrom

    Citation: BMC Microbiology 2016 16:156

    Content type: Research article

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  10. Bacteroides fragilis is the most frequent species at the human intestinal mucosal surface, it contributes to the maturation of the immune system although is also considered as an oppor...

    Authors: David Rios-Covian, Isabel Cuesta, Jorge R. Alvarez-Buylla, Patricia Ruas-Madiedo, Miguel Gueimonde and Clara G. de los Reyes-Gavilán

    Citation: BMC Microbiology 2016 16:150

    Content type: Research article

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  11. Pseudomonas aeruginosa (Pa) is a Gram-negative bacteria frequently involved in healthcare-associated pneumonia with poor clinical outcome. To face the announced post-antibiotic era due...

    Authors: Perrine Bortolotti, Benjamin Hennart, Camille Thieffry, Guillaume Jausions, Emmanuel Faure, Teddy Grandjean, Marion Thepaut, Rodrigue Dessein, Delphine Allorge, Benoit P. Guery, Karine Faure, Eric Kipnis, Bertrand Toussaint and Audrey Le Gouellec

    Citation: BMC Microbiology 2016 16:137

    Content type: Research article

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  12. Biodegradation of rubber (polyisoprene) is initiated by oxidative cleavage of the polyisoprene backbone and is performed either by an extracellular rubber oxygenase (RoxA) from Gram-negative rubber degrading b...

    Authors: Sirimaporn Watcharakul, Wolf Röther, Jakob Birke, Kamontam Umsakul, Brian Hodgson and Dieter Jendrossek

    Citation: BMC Microbiology 2016 16:92

    Content type: Research article

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  13. The emergence of antibiotic resistant pathogenic bacteria has reduced our ability to combat infectious diseases. At the same time the numbers of new antibiotics reaching the market have decreased. This situati...

    Authors: Verena Hoerr, Gavin E. Duggan, Lori Zbytnuik, Karen K. H. Poon, Christina Große, Ute Neugebauer, Karen Methling, Bettina Löffler and Hans J. Vogel

    Citation: BMC Microbiology 2016 16:82

    Content type: Research article

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  14. The betaproteobacterium Thauera linaloolentis 47LolT was isolated on the tertiary monoterpene alcohol (R,S)-linalool as sole carbon and energy source under denitrifying conditions. Growth experiments indicated th...

    Authors: Robert Marmulla, Edinson Puentes Cala, Stephanie Markert, Thomas Schweder and Jens Harder

    Citation: BMC Microbiology 2016 16:76

    Content type: Research article

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  15. Vibrio parahaemolyticus is a main causative agent of serious human seafood-borne gastroenteritis disease. Many researchers have investigated its pathogenesis by observing the alteratio...

    Authors: Bo Feng, Zhuoran Guo, Weijia Zhang, Yingjie Pan and Yong Zhao

    Citation: BMC Microbiology 2016 16:75

    Content type: Research article

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  16. Tetracyclines are among the most used antibiotics in livestock worldwide. Resistance is widely disseminated in Escherichia coli, where it is generally mediated by tetracycline efflux pumps, such as TetA. Expressi...

    Authors: Thea S. B. Møller, Martin Overgaard, Søren S. Nielsen, Valeria Bortolaia, Morten O. A Sommer, Luca Guardabassi and John E. Olsen

    Citation: BMC Microbiology 2016 16:39

    Content type: Research article

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  17. Helicobacter pylori MutS2 (HpMutS2), an inhibitor of recombination during transformation is a non-specific nuclease with two catalytic sites, both of which are essential for its anti-recombin...

    Authors: Prashant P. Damke, Rajkumar Dhanaraju, Stéphanie Marsin, J. Pablo Radicella and Desirazu N. Rao

    Citation: BMC Microbiology 2016 16:14

    Content type: Research article

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    The Correction to this article has been published in BMC Microbiology 2019 19:190

  18. Clostridium difficile is one of the major nosocomial threats causing severe gastrointestinal infections. Compared to the well documented clinical symptoms, little is known about the pr...

    Authors: Meina Neumann-Schaal, Julia Danielle Hofmann, Sabine Eva Will and Dietmar Schomburg

    Citation: BMC Microbiology 2015 15:281

    Content type: Research article

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  19. Nucleotide sugar transporters (NSTs) play an essential role in translocating nucleotide sugars into the lumen of the endoplasmic reticulum and Golgi apparatus to be used as substrates in glycosylation reaction...

    Authors: Carlos Gustavo Baptista, Elizabeth Cristina Rodrigues, Patricia Morking, Amanda Klinke, Maria Luiza Zardo, Maurílio José Soares, Alessandra Melo de Aguiar, Samuel Goldenberg and Augusto Savio Peixoto Ramos

    Citation: BMC Microbiology 2015 15:269

    Content type: Research article

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  20. Fungi are ubiquitous in nature and have evolved over time to colonize a wide range of ecosystems including pest control. To date, most research has focused on the hypocrealean genera Beauveria bassiana, which is ...

    Authors: Hongxia Liu, Xusheng Zhao, Mingxin Guo, Hui Liu and Zhiming Zheng

    Citation: BMC Microbiology 2015 15:267

    Content type: Research article

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  21. Angomonas deanei is a trypanosomatid parasite of insects that has a bacterial endosymbiont, which supplies amino acids and other nutrients to its host. Bacterium loss induced by antibi...

    Authors: Simone Santiago Carvalho de Oliveira, Aline dos Santos Garcia-Gomes, Claudia Masini d’Avila-Levy, André Luis Souza dos Santos and Marta Helena Branquinha

    Citation: BMC Microbiology 2015 15:188

    Content type: Research article

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  22. Paracoccidioides spp is a fungi genus and the agent of paracoccidioidomycosis. The strategies of infection used by these pathogens involve the expression of proteins related to adaptation to the host, particular...

    Authors: Haroldo Cesar de Oliveira, Julhiany de Fátima da Silva, Marcelo Teruyuki Matsumoto, Caroline Maria Marcos, Roberta Peres da Silva, Rosângela Aparecida Moraes da Silva, Mônica Teresa Veneziano Labate, Carlos Alberto Labate, Ana Marisa Fusco Almeida and Maria José Soares Mendes Giannini

    Citation: BMC Microbiology 2014 14:302

    Content type: Research article

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  23. Forestomach fermentation in Australian marsupials such as wallabies and kangaroos, though analogous to rumen fermentation, results in lower methane emissions. Insights into hydrogenotrophy in these systems cou...

    Authors: Emma J Gagen, Jiakun Wang, Jagadish Padmanabha, Jing Liu, Isabela Pena Carvalho de Carvalho, Jianxin Liu, Richard I Webb, Rafat Al Jassim, Mark Morrison, Stuart E Denman and Christopher S McSweeney

    Citation: BMC Microbiology 2014 14:314

    Content type: Research article

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  24. Genetic models have been developed in divergent branches of the class Alphaproteobacteria to help answer a wide spectrum of questions regarding bacterial physiology. For example, Sinorhizobium meliloti serves as ...

    Authors: Mina Mostafavi, Jainee Christa Lewis, Tanisha Saini, Julian Albert Bustamante, Ivan Thomas Gao, Tuyet Thi Tran, Sean Nicholas King, Zhenzhong Huang and Joseph C Chen

    Citation: BMC Microbiology 2014 14:295

    Content type: Research article

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  25. Bifidobacteria constitute a specific group of commensal bacteria that commonly inhabit the mammalian gastrointestinal tract. Bifidobacterium breve UCC2003 was previously shown to utilize a variety of plant/diet/h...

    Authors: Muireann Egan, Mary O’Connell Motherway, Michelle Kilcoyne, Marian Kane, Lokesh Joshi, Marco Ventura and Douwe van Sinderen

    Citation: BMC Microbiology 2014 14:282

    Content type: Research article

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  26. Many studies on M. tuberculosis have emerged from using M. smegmatis MC 2 155 (Msm), since they share significant similarities and yet Msm is non-pathogenic and faster growin...

    Authors: Priyanka Baloni, Jyothi Padiadpu, Anupam Singh, Kuldeepkumar R Gupta and Nagasuma Chandra

    Citation: BMC Microbiology 2014 14:276

    Content type: Research article

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  27. Campylobacter jejuni and C. coli are human intestinal pathogens that are the most frequent causes of bacterial foodborne gastroenteritis in humans in the UK. In this study, we aimed to characterise the metabolic...

    Authors: Sariqa Wagley, Jane Newcombe, Emma Laing, Emmanuel Yusuf, Christine M Sambles, David J Studholme, Roberto M La Ragione, Richard W Titball and Olivia L Champion

    Citation: BMC Microbiology 2014 14:262

    Content type: Research article

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  28. Thiamine (vitamin B1) is synthesized de novo by certain yeast, fungi, plants, protozoans, bacteria and archaea. The pathway of thiamine biosynthesis by archaea is poorly understood, particularly the route of sulf...

    Authors: Sungmin Hwang, Bryan Cordova, Nikita Chavarria, Dina Elbanna, Stephen McHugh, Jenny Rojas, Friedhelm Pfeiffer and Julie A Maupin-Furlow

    Citation: BMC Microbiology 2014 14:260

    Content type: Research article

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  29. At high concentrations of organic substrates, microbial utilization of preferred substrates (i.e., supporting fast growth) often results in diauxic growth with hierarchical substrate depletion. Unlike the carb...

    Authors: Sven Lahme, Kathleen Trautwein, Annemieke Strijkstra, Marvin Dörries, Lars Wöhlbrand and Ralf Rabus

    Citation: BMC Microbiology 2014 14:269

    Content type: Research article

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  30. In a multicellular organism, the extracellular matrix (ECM) provides a cell-supporting scaffold and helps maintaining the biophysical integrity of tissues and organs. At the same time it plays crucial roles in...

    Authors: Fábio Faria-Oliveira, Joana Carvalho, Celso LR Belmiro, Montserrat Martinez-Gomariz, Maria Luisa Hernaez, Mauro Pavão, Concha Gil, Cândida Lucas and Célia Ferreira

    Citation: BMC Microbiology 2014 14:244

    Content type: Methodology article

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  31. Trypanosoma cruzi, the etiologic agent of Chagas disease, alternates between distinct morphological and functional forms during its life cycle. Axenic multiplication and differentiation processes of this protozo...

    Authors: Carla V De Paula Lima, Michel Batista, Fernanda G Kugeratski, Isabel M Vincent, Maurilio J Soares, Christian M Probst, Marco A Krieger and Fabricio K Marchini

    Citation: BMC Microbiology 2014 14:238

    Content type: Research article

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  32. Bacterial sortases are transpeptidases that covalently anchor surface proteins to the peptidoglycan of the Gram-positive cell wall. Sortase protein anchoring is mediated by a conserved cell wall sorting signal...

    Authors: Elizabeth H Donahue, Lisa F Dawson, Esmeralda Valiente, Stuart Firth-Clark, Meriel R Major, Eddy Littler, Trevor R Perrior and Brendan W Wren

    Citation: BMC Microbiology 2014 14:219

    Content type: Research article

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  33. Salmonellae are food-borne pathogens of great health and economic importance. To pose a threat to humans, Salmonellae normally have to cope with a series of stressful conditions in the food chain, including low ...

    Authors: Gitte Maegaard Knudsen, Maj-Britt Nielsen, Line Elnif Thomsen, Søren Aabo, Ivan Rychlik and John Elmerdahl Olsen

    Citation: BMC Microbiology 2014 14:208

    Content type: Research article

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  34. Selenium (Se) is an essential trace element in most organisms but has to be carefully handled since there is a thin line between beneficial and toxic concentrations. Many bacteria have the ability to reduce se...

    Authors: Shixue Zheng, Jing Su, Liang Wang, Rong Yao, Dan Wang, Yujia Deng, Rui Wang, Gejiao Wang and Christopher Rensing

    Citation: BMC Microbiology 2014 14:204

    Content type: Research article

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  35. Streptococcus mutans is known to be a primary etiological factor of dental caries, a widespread and growing disease in Polish children. Recognition of novel features determining the pathogenicity of this pathoge...

    Authors: Wirginia Krzyściak, Katarzyna K Pluskwa, Jakub Piątkowski, Paweł Krzyściak, Anna Jurczak, Dorota Kościelniak and Anna Skalniak

    Citation: BMC Microbiology 2014 14:194

    Content type: Research article

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  36. Resistance to fluconazole, a commonly used azole antifungal, is a challenge for the treatment of fungal infections. Resistance can be mediated by overexpression of ABC transporters, which promote drug efflux t...

    Authors: Leandro Figueira Reis de Sá, Fabiano Travanca Toledo, Bruno Artur de Sousa, Augusto César Gonçalves, Ana Claudia Tessis, Edison P Wendler, João V Comasseto, Alcindo A Dos Santos and Antonio Ferreira-Pereira

    Citation: BMC Microbiology 2014 14:201

    Content type: Research article

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  37. Shewanella oneidensis MR-1 exhibits extracellular electron transfer (EET) activity that is influenced by various cellular components, including outer-membrane cytochromes, cell-surface polysaccharides (CPS), and...

    Authors: Atsushi Kouzuma, Hitomi Oba, Nozomi Tajima, Kazuhito Hashimoto and Kazuya Watanabe

    Citation: BMC Microbiology 2014 14:190

    Content type: Research article

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  38. The Gram-negative bacterium Erwinia amylovora is the causal agent of the devastating disease fire blight in rosaceous plants such as apple, pear, quince, raspberry, and cotoneaster. In order to survive and multip...

    Authors: Daniel Pletzer and Helge Weingart

    Citation: BMC Microbiology 2014 14:185

    Content type: Research article

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  39. SigX (σX), the alternative sigma factor of Streptococcus mutans, is the key regulator for transcriptional activation of late competence genes essential for taking up exogenous DNA. Recent studies reveal that adap...

    Authors: Gaofeng Dong, Xiao-Lin Tian, Zubelda A Gomez and Yung-Hua Li

    Citation: BMC Microbiology 2014 14:183

    Content type: Research article

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  40. Malaria continues to be a devastating disease. The elucidation of factors inducing asexual growth versus arrest of Plasmodium falciparum can provide information about the development of the parasite, and may help...

    Authors: Hiroko Asahi, Mohammed Essa Marghany Tolba, Masanobu Tanabe, Sumio Sugano, Kazumi Abe and Fumihiko Kawamoto

    Citation: BMC Microbiology 2014 14:167

    Content type: Research article

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  41. Magnetotactic bacteria are capable of synthesizing magnetosomes only under oxygen-limited conditions. However, the mechanism of the aerobic repression on magnetite biomineralization has remained unknown. In Esche...

    Authors: Yingjie Li, Monique Sabaty, Sarah Borg, Karen T Silva, David Pignol and Dirk Schüler

    Citation: BMC Microbiology 2014 14:153

    Content type: Research article

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  42. Denitrification is defined as the dissimilatory reduction of nitrate or nitrite to nitric oxide (NO), nitrous oxide (N2O), or dinitrogen gas (N2). N2O is a powerful atmospheric greenhouse gas and cause of ozone l...

    Authors: Maria J Torres, Maria I Rubia, Teodoro Coba de la Peña, José J Pueyo, Eulogio J Bedmar and María J Delgado

    Citation: BMC Microbiology 2014 14:142

    Content type: Research article

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  43. Microbial gene expression is strongly influenced by environmental growth conditions. Comparison of gene expression under different conditions is frequently used for functional analysis and to unravel regulator...

    Authors: Ishwar Bajaj, Tânia Veiga, Dino van Dissel, Jack T Pronk and Jean-Marc Daran

    Citation: BMC Microbiology 2014 14:114

    Content type: Research article

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