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Microbe-host interactions and microbial pathogenicity

Section edited by David Nelson

This section aims to publish studies looking at all aspects of microbe-host interactions and pathogenicity including pathogenic mechanisms, virulence factors, host invasion, immune evasion, host defence, immunity, immunology and symbiotic interactions.

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  1. Toxin complex (Tc) family proteins were first identified as insecticidal toxins in Photorhabdus luminescens and have since been found in a wide range of bacteria. The genome of Yersinia pestis, the causative agen...

    Authors: Justin L Spinner, Clayton O Jarrett, Doris L LaRock, Samuel I Miller, Carleen M Collins and B Joseph Hinnebusch

    Citation: BMC Microbiology 2012 12:296

    Content type: Research article

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  2. Burkholderia pseudomallei and B. mallei are closely related Category B Select Agents of bioterrorism and the causative agents of the diseases melioidosis and glanders, respectively. Rapid phage-based diagnostic t...

    Authors: Brian H Kvitko, Christopher R Cox, David DeShazer, Shannon L Johnson, Kent J Voorhees and Herbert P Schweizer

    Citation: BMC Microbiology 2012 12:289

    Content type: Research article

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  3. Candida albicans is a human fungal pathogen, able to cause both superficial and serious, systemic diseases and is able to switch from yeast cells to long, tube-like hyphae, depending on the prevailing environment...

    Authors: Ekaterina S Ovchinnikova, Bastiaan P Krom, Henk J Busscher and Henny C van der Mei

    Citation: BMC Microbiology 2012 12:281

    Content type: Research article

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  4. Staphylococcus aureus strains with distinct genetic backgrounds have shown different virulence in animal models as well as associations with different clinical outcomes, such as causing infection in the hospital ...

    Authors: Kaiyu Wu, John Conly, Michael Surette, Christopher Sibley, Sameer Elsayed and Kunyan Zhang

    Citation: BMC Microbiology 2012 12:274

    Content type: Research article

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  5. Prophages of enteric bacteria are frequently of key importance for the biology, virulence, or host adaptation of their host. Some C. jejuni isolates carry homologs of the CJIE1 (CMLP 1) prophage that carry cargo ...

    Authors: Clifford G Clark, Christopher CR Grant, Frank Pollari, Barbara Marshall 3, Jason Moses, Dobryan M Tracz and Matthew W Gilmour

    Citation: BMC Microbiology 2012 12:269

    Content type: Research article

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  6. The morphogenesis of herpes simplex virus type 1 (HSV-1) comprises several events, of which some are not completely understood. It has been shown that HSV-1 glycoproteins accumulate in the trans-Golgi network (TG...

    Authors: Raquel Bello-Morales, Antonio Jesús Crespillo, Alberto Fraile-Ramos, Enrique Tabarés, Antonio Alcina and José Antonio López-Guerrero

    Citation: BMC Microbiology 2012 12:265

    Content type: Research article

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  7. Nontypeable Haemophilus influenzae (NTHi) is a significant human pathogen responsible for respiratory tract infections and the most common cause of recurrent otitis media. Type II toxin-antitoxin (TA) systems are...

    Authors: Dabin Ren, Anna N Walker and Dayle A Daines

    Citation: BMC Microbiology 2012 12:263

    Content type: Research article

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  8. The genetic features that facilitate Campylobacter jejuni’s adaptation to a wide range of environments are not completely defined. However, whole genome expression studies showed that respiratory proteins (RPs) w...

    Authors: Issmat I Kassem, Mahesh Khatri, Malak A Esseili, Yasser M Sanad, Yehia M Saif, Jonathan W Olson and Gireesh Rajashekara

    Citation: BMC Microbiology 2012 12:258

    Content type: Research article

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  9. The classical roles of B cells include the production of antibodies and cytokines and the generation of immunological memory, these being key factors in the adaptive immune response. However, their role in inn...

    Authors: Blanca Estela García-Pérez, Juan José De la Cruz-López, Jorge Ismael Castañeda-Sánchez, Ana Rosa Muñóz-Duarte, Alma Delia Hernández-Pérez, Hilda Villegas-Castrejón, Ethel García-Latorre, Angel Caamal-Ley and Julieta Luna-Herrera

    Citation: BMC Microbiology 2012 12:246

    Content type: Research article

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  10. Efficient perception of attacking pathogens is essential for plants. Plant defense is evoked by molecules termed elicitors. Endogenous elicitors or damage-associated molecular patterns (DAMPs) originate from p...

    Authors: Frank-Jörg Vorhölter, Heinrich-Günter Wiggerich, Heiko Scheidle, Vishaldeep Kaur Sidhu, Kalina Mrozek, Helge Küster, Alfred Pühler and Karsten Niehaus

    Citation: BMC Microbiology 2012 12:239

    Content type: Research article

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  11. Campylobacter jejuni is a major cause of bacterial food-borne illness in Europe and North America. The mechanisms allowing survival in the environment and transmission to new hosts are not well understood. Enviro...

    Authors: Xuan Thanh Bui, Klaus Qvortrup, Anders Wolff, Dang Duong Bang and Carole Creuzenet

    Citation: BMC Microbiology 2012 12:232

    Content type: Research article

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  12. Enterohemorrhagic Escherichia coli (EHEC) colonizes the intestinal epithelium and causes attaching and effacing (A/E) lesions. Expression of virulence genes, particularly those from the locus of the enterocyte ef...

    Authors: Anne-Marie Hansen and Ding Jun Jin

    Citation: BMC Microbiology 2012 12:231

    Content type: Research article

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  13. Coccidioidomycosis results from airborne infections caused by either Coccidioides immitis or C. posadasii. Both are pathogenic fungi that live in desert soil in the New World and can infect normal hosts, but most...

    Authors: Christopher H Woelk, Jin X Zhang, Lorraine Walls, Suganya Viriyakosol, Akul Singhania, Theo N Kirkland and Joshua Fierer

    Citation: BMC Microbiology 2012 12:218

    Content type: Research article

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  14. The genus Mycobacterium (M.) comprises highly pathogenic bacteria such as M. tuberculosis as well as environmental opportunistic bacteria called non-tuberculous mycobacteria (NTM). While the incidence of tubercul...

    Authors: Faisal Asghar Khattak, Ashutosh Kumar, Elisabeth Kamal, Ralph Kunisch and Astrid Lewin

    Citation: BMC Microbiology 2012 12:204

    Content type: Research article

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  15. Klebsiella pneumoniae is an important opportunistic pathogen causing pneumonia, sepsis and urinary tract infections. Colonisation of the gastrointestinal (GI) tract is a key step in the development of infections;...

    Authors: Erik J Boll, Lene N Nielsen, Karen A Krogfelt and Carsten Struve

    Citation: BMC Microbiology 2012 12:201

    Content type: Research article

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  16. The accumulation of thick stagnant mucus provides a suitable environment for the growth of Pseudomonas aeruginosa and Staphylococcus aureus within the lung alveoli of cystic fibrosis (CF) patients. These infectio...

    Authors: Cecily L Haley, Jane A Colmer-Hamood and Abdul N Hamood

    Citation: BMC Microbiology 2012 12:181

    Content type: Research article

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  17. B. bronchiseptica infections are usually associated with wild or domesticated animals, but infrequently with humans. A recent phylogenetic analysis distinguished two distinct B. bronchiseptica subpopulations, des...

    Authors: Umesh Ahuja, Minghsun Liu, Shuta Tomida, Jihye Park, Puneet Souda, Julian Whitelegge, Huiying Li, Eric T Harvill, Julian Parkhill and Jeff F Miller

    Citation: BMC Microbiology 2012 12:167

    Content type: Research article

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  18. Mycobacterium tuberculosis differs from most pathogens in its ability to multiply inside monocytes and to persist during long periods of time within granuloma in a status of latency. A class of proteins called my...

    Authors: Ralph Kunisch, Elisabeth Kamal and Astrid Lewin

    Citation: BMC Microbiology 2012 12:165

    Content type: Research article

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  19. Studies on mycorrhiza associated bacteria suggest that bacterial-fungal interactions play important roles during mycorrhiza formation and affect plant health. We surveyed Streptomyces Actinobacteria, known as ant...

    Authors: Silvia D Schrey, Eric Erkenbrack, Elisabeth Früh, Svenja Fengler, Kerstin Hommel, Nadine Horlacher, Dirk Schulz, Margret Ecke, Andreas Kulik, Hans-Peter Fiedler, Rüdiger Hampp and Mika T Tarkka

    Citation: BMC Microbiology 2012 12:164

    Content type: Research article

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  20. Enterovirus 71 (EV71) is a major causative agent of hand-foot-and-mouth disease (HFMD), and infection of EV71 to central nerve system (CNS) may result in a high mortality in children less than 2 years old. Alt...

    Authors: Pei-Yi Su, Yueh-Tung Liu, Hsin-Yueh Chang, Sheng-Wen Huang, Ya-Fang Wang, Chun-Keung Yu, Jen-Ren Wang and Chuan-Fa Chang

    Citation: BMC Microbiology 2012 12:162

    Content type: Research article

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  21. Plague is caused by Yersinia pestis, a bacterium that disseminates inside of the host at remarkably high rates. Plague bacilli disrupt normal immune responses in the host allowing for systematic spread that is fa...

    Authors: Rodrigo J Gonzalez, Eric H Weening, Richard Frothingham, Gregory D Sempowski and Virginia L Miller

    Citation: BMC Microbiology 2012 12:147

    Content type: Methodology article

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  22. Avian pathogenic Escherichia coli (APEC) and uropathogenic E. coli (UPEC) are the two main subsets of extraintestinal pathogenic E. coli (ExPEC). Both types have multiple iron acquisition systems, including heme ...

    Authors: Qingqing Gao, Xiaobo Wang, Huiqing Xu, Yaya Xu, Jielu Ling, Debao Zhang, Song Gao and Xiufan Liu

    Citation: BMC Microbiology 2012 12:143

    Content type: Research article

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  23. Deoxyhypusine synthase (DHS) catalyzes the first step in hypusine biosynthesis of eukaryotic initiation factor 5A (eIF-5A) in Plasmodium falciparum. Target evaluation of parasitic DHS has recently been performed ...

    Authors: Andreas Schwentke, Marcel Krepstakies, Ann-Kristin Mueller, Christiane Hammerschmidt-Kamper, Basma A Motaal, Tina Bernhard, Joachim Hauber and Annette Kaiser

    Citation: BMC Microbiology 2012 12:107

    Content type: Research article

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  24. Diseases from Staphylococcus aureus are a major problem in Indian hospitals and recent studies point to infiltration of community associated methicillin resistant S. aureus (CA-MRSA) into hospitals. Although CA-M...

    Authors: Srikanth Shambat, Savitha Nadig, Sushma Prabhakara, Michele Bes, Jerome Etienne and Gayathri Arakere

    Citation: BMC Microbiology 2012 12:64

    Content type: Research article

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  25. A powerful approach to understanding complex processes such as aging is to use model organisms amenable to genetic manipulation, and to seek relevant phenotypes to measure. Caenorhabditis elegans is particularly ...

    Authors: Cynthia Portal-Celhay, Ellen R Bradley and Martin J Blaser

    Citation: BMC Microbiology 2012 12:49

    Content type: Research article

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  26. The experimental murine model of leishmaniasis has been widely used to characterize the immune response against Leishmania. CBA mice develop severe lesions, while C57BL/6 present small chronic lesions under L. am...

    Authors: Christian M Probst, Rodrigo A Silva, Juliana P B Menezes, Tais F Almeida, Ivana N Gomes, Andréia C Dallabona, Luiz S Ozaki, Gregory A Buck, Daniela P Pavoni, Marco A Krieger and Patrícia S T Veras

    Citation: BMC Microbiology 2012 12:22

    Content type: Research article

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  27. The production of virulence factors in Staphylococcus aureus is tightly controlled by a complex web of interacting regulators. EsxA is one of the virulence factors that are excreted by the specialized, type VII-l...

    Authors: Bettina Schulthess, Dominik A Bloes and Brigitte Berger-Bächi

    Citation: BMC Microbiology 2012 12:17

    Content type: Research article

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  28. Epithelial cells of the urinary tract recognize pathogenic bacteria through pattern recognition receptors on their surface, such as toll-like receptors (TLRs), and mount an immune response through the activati...

    Authors: Mattias Karlsson, Nikolai Scherbak, Gregor Reid and Jana Jass

    Citation: BMC Microbiology 2012 12:15

    Content type: Research article

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  29. The association between Helicobacter pylori infection and upper gastrointestinal disease is well established. However, only a small fraction of H. pylori carriers develop disease, and there are great geographical...

    Authors: Lars L Eftang, Ying Esbensen, Tone M Tannæs, Ida RK Bukholm and Geir Bukholm

    Citation: BMC Microbiology 2012 12:9

    Content type: Research article

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  30. A common finding amongst patients with inhalational anthrax is a paucity of polymorphonuclear leukocytes (PMNs) in infected tissues in the face of abundant circulating PMNs. A major virulence determinant of an...

    Authors: Chinh Nguyen, Chiguang Feng, Min Zhan, Alan S Cross and Simeon E Goldblum

    Citation: BMC Microbiology 2012 12:2

    Content type: Research article

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  31. Aggregation may play a main role in the adhesion of bacteria to the gastrointestinal epithelium and their colonization ability, as well as in probiotic effects through co-aggregation with intestinal pathogens ...

    Authors: Milan Kojic, Branko Jovcic, Ivana Strahinic, Jelena Begovic, Jelena Lozo, Katarina Veljovic and Ljubisa Topisirovic

    Citation: BMC Microbiology 2011 11:265

    Content type: Research article

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  32. Staphylococcus aureus is a well-armed pathogen prevalent in severe infections such as endocarditis and osteomyelitis. Fibronectin-binding proteins A and B, encoded by fnbA/B, are major pathogenesis determinants i...

    Authors: Jean Philippe Rasigade, Abdelmalek Moulay, Yannick Lhoste, Anne Tristan, Michele Bes, François Vandenesch, Jerome Etienne, Gerard Lina, Frederic Laurent and Oana Dumitrescu

    Citation: BMC Microbiology 2011 11:263

    Content type: Research article

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  33. Candida can cause mucocutaneous and/or systemic infections in hospitalized and immunosuppressed patients. Most individuals are colonized by Candida spp. as part of the oral flora and the intestinal tract. We comp...

    Authors: Juliana C Junqueira, Beth B Fuchs, Maged Muhammed, Jeffrey J Coleman, Jamal MAH Suleiman, Simone FG Vilela, Anna CBP Costa, Vanessa MC Rasteiro, Antonio OC Jorge and Eleftherios Mylonakis

    Citation: BMC Microbiology 2011 11:247

    Content type: Research article

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  34. Streptococcus pneumoniae (the pneumococcus) is the leading cause of otitis media, community-acquired pneumonia (CAP), sepsis, and meningitis. It is now evident that S. pneumoniae forms biofilms during nasopharyng...

    Authors: Carlos J Sanchez, Brady J Hurtgen, Anel Lizcano, Pooja Shivshankar, Garry T Cole and Carlos J Orihuela

    Citation: BMC Microbiology 2011 11:245

    Content type: Research article

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  35. Arcanobacterium haemolyticum is an emerging human pathogen that causes pharyngitis, wound infections, and a variety of occasional invasive diseases. Since its initial discovery in 1946, this Gram positive organis...

    Authors: B Helen Jost, Erynn A Lucas, Stephen J Billington, Adam J Ratner and David J McGee

    Citation: BMC Microbiology 2011 11:239

    Content type: Research article

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  36. Indoor microbial contamination due to excess moisture is an important contributor to human illness in both residential and occupational settings. However, the census of microorganisms in the indoor environment...

    Authors: Miia Pitkäranta, Teija Meklin, Anne Hyvärinen, Aino Nevalainen, Lars Paulin, Petri Auvinen, Ulla Lignell and Helena Rintala

    Citation: BMC Microbiology 2011 11:235

    Content type: Research article

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  37. Filamentous M13 phage extrude from infected Escherichia coli with a tip structure composed of gp7 and gp9. This tip structure is extended by the assembly of the filament composed of the major coat protein gp8. Fi...

    Authors: Martin Ploss and Andreas Kuhn

    Citation: BMC Microbiology 2011 11:211

    Content type: Research article

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    The Erratum to this article has been published in BMC Microbiology 2017 17:180

  38. Haemophilus ducreyi, the causative agent of the sexually transmitted disease chancroid, contains a flp (fimbria like protein) operon that encodes proteins predicted to contribute to adherence and pathogenesis. H....

    Authors: Diane M Janowicz, Sean A Cooney, Jessica Walsh, Beth Baker, Barry P Katz, Kate R Fortney, Beth W Zwickl, Sheila Ellinger and Robert S Munson Jr

    Citation: BMC Microbiology 2011 11:208

    Content type: Research article

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  39. Moraxella catarrhalis, a major nasopharyngeal pathogen of the human respiratory tract, is exposed to rapid downshifts of environmental temperature when humans breathe cold air. It was previously shown that the pr...

    Authors: Violeta Spaniol, Rolf Troller, André Schaller and Christoph Aebi

    Citation: BMC Microbiology 2011 11:182

    Content type: Research article

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  40. A number of studies have revealed that Francisella tularensis (FT) suppresses innate immune responses such as chemokine/cytokine production and neutrophil recruitment in the lungs following pulmonary infection vi...

    Authors: Himangi R Jayakar, Jyothi Parvathareddy, Elizabeth A Fitzpatrick, Xiaowen R Bina, James E Bina, Fabio Re, Felicia D Emery and Mark A Miller

    Citation: BMC Microbiology 2011 11:179

    Content type: Research article

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  41. Recently our group has identified a novel antigen of Mycobacterium tuberculosis, protein PPE44, belonging to the "PPE protein" family. Although its role in infection is largely unknown, PPE44-specific immune resp...

    Authors: Barbara Cuccu, Giulia Freer, Alessandro Genovesi, Carlo Garzelli and Laura Rindi

    Citation: BMC Microbiology 2011 11:167

    Content type: Research article

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  42. The West Nile virus (WNV) nonstructural protein 1 (NS1) is an important antigenic protein that elicits protective antibody responses in animals and can be used for the serological diagnosis of WNV infection. A...

    Authors: En-Cheng Sun, Jian-Nan Ma, Ni-Hong Liu, Tao Yang, Jing Zhao, Hong-Wei Geng, Ling-Feng Wang, Yong-Li Qin, Zhi-Gao Bu, Yin-Hui Yang, Ross A Lunt, Lin-Fa Wang and Dong-Lai Wu

    Citation: BMC Microbiology 2011 11:160

    Content type: Research article

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  43. Foot-and-mouth disease virus (FMDV) uses a highly conserved Arg-Gly-Asp (RGD) triplet for attachment to host cells and this motif is believed to be essential for virus viability. Previous sequence analyses of ...

    Authors: Pinghua Li, Zengjun Lu, Huifang Bao, Dong Li, Donald P King, Pu Sun, Xingwen Bai, Weijun Cao, Simon Gubbins, Yingli Chen, Baoxia Xie, Jianhong Guo, Hong Yin and Zaixin Liu

    Citation: BMC Microbiology 2011 11:154

    Content type: Research article

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