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Microbe-host interactions and microbial pathogenicity

This section aims to publish studies looking at all aspects of microbe-host interactions and pathogenicity including pathogenic mechanisms, virulence factors, host invasion, immune evasion, host defence, immunity, immunology and symbiotic interactions.

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  1. Epidemiological studies relate influenza infection with vascular diseases like myocardial infarction. The hypothesis that influenza infection has procoagulant effects on humans has been investigated by experim...

    Authors: Marco Goeijenbier, Eric CM van Gorp, Judith MA Van den Brand, Koert Stittelaar, Kamran Bakhtiari, Joris JTH Roelofs, Geert van Amerongen, Thijs Kuiken, Byron EE Martina, Joost CM Meijers and Albert DME Osterhaus

    Citation: BMC Microbiology 2014 14:134

    Content type: Research article

    Published on:

  2. Recent scientific developments have shed more light on the importance of the host-microbe interaction, particularly in the gut. However, the mechanistic study of the host-microbe interplay is complicated by th...

    Authors: Massimo Marzorati, Barbara Vanhoecke, Tine De Ryck, Mehdi Sadaghian Sadabad, Iris Pinheiro, Sam Possemiers, Pieter Van den Abbeele, Lara Derycke, Marc Bracke, Jan Pieters, Tom Hennebel, Hermie J Harmsen, Willy Verstraete and Tom Van de Wiele

    Citation: BMC Microbiology 2014 14:133

    Content type: Methodology article

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  3. Phospholipases C (PLCs) are virulence factors found in several bacteria. In Mycobacterium tuberculosis (Mtb) they exhibit cytotoxic effects on macrophages, but the mechanisms involved in PLC-induced cell death ar...

    Authors: Patricia A Assis, Milena S Espíndola, Francisco WG Paula-Silva, Wendy M Rios, Priscilla AT Pereira, Sylvia C Leão, Célio L Silva and Lúcia H Faccioli

    Citation: BMC Microbiology 2014 14:128

    Content type: Research article

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  4. Previous findings suggested that Lactobacillus rhamnosus CRL1505 is able to increase resistance of children to intestinal viral infections. However, the intestinal cells, cytokines and receptors involved in the i...

    Authors: Julio Villena, Eriko Chiba, Maria Guadalupe Vizoso-Pinto, Yohsuke Tomosada, Takuya Takahashi, Takamasa Ishizuka, Hisashi Aso, Susana Salva, Susana Alvarez and Haruki Kitazawa

    Citation: BMC Microbiology 2014 14:126

    Content type: Research article

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  5. Burkholderia pseudomallei is the causative agent of melioidosis, a potentially fatal disease endemic in Southeast Asia and Northern Australia. This Gram-negative pathogen possesses numerous virulence factors inc...

    Authors: Boon Eng Teh, Christopher Todd French, Yahua Chen, Isabelle Gek Joo Chen, Ting-Hsiang Wu, Enrico Sagullo, Pei-Yu Chiou, Michael A Teitell, Jeff F Miller and Yunn-Hwen Gan

    Citation: BMC Microbiology 2014 14:115

    Content type: Research article

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  6. Burkholderia pseudomallei (Bp), a Gram-negative, motile, facultative intracellular bacterium is the causative agent of melioidosis in humans and animals. The Bp genome encodes a repertoire of virulence factors, ...

    Authors: Gianluca Pegoraro, Brett P Eaton, Ricky L Ulrich, Douglas J Lane, Jenifer F Ojeda, Sina Bavari, David DeShazer and Rekha G Panchal

    Citation: BMC Microbiology 2014 14:98

    Content type: Methodology article

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  7. Several bacterial plant pathogens colonize their hosts through the secretion of effector proteins by a Type III protein secretion system (T3SS). The role of T3SS in bacterial pathogenesis is well established b...

    Authors: Tamara Zimaro, Ludivine Thomas, Claudius Marondedze, Germán G Sgro, Cecilia G Garofalo, Florencia A Ficarra, Chris Gehring, Jorgelina Ottado and Natalia Gottig

    Citation: BMC Microbiology 2014 14:96

    Content type: Research article

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  8. Autotransporters form a large family of outer membrane proteins specifying diverse biological traits of Gram-negative bacteria. In this study, we report the identification and characterization of a novel autot...

    Authors: Eric R Lafontaine, Rachel Balder, Frank Michel and Robert J Hogan

    Citation: BMC Microbiology 2014 14:92

    Content type: Research article

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  9. Human influenza virus hemagglutinin prefers to use sialic acid (SA) receptors via α-2,6 linkages. The β-galactoside α-2,6-sialyltransferase I (ST6Gal I) protein is encoded by the ST6GAL1 gene and is responsibl...

    Authors: Dong Wu, Wenbo Huang, Yutao Wang, Wenda Guan, Runfeng Li, Zifeng Yang and Nanshan Zhong

    Citation: BMC Microbiology 2014 14:78

    Content type: Research article

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  10. Toxoplasma gondii hijacks host cells to allow it to disseminate throughout a host animal; however, the migratory machinery involved in this process has not been well characterized. We examined the functional rol...

    Authors: Hany M Ibrahim, Maki Nishimura, Sachi Tanaka, Walaa Awadin, Hidefumi Furuoka, Xuenan Xuan and Yoshifumi Nishikawa

    Citation: BMC Microbiology 2014 14:76

    Content type: Research article

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  11. Streptococcus suis serotype 2 (S. suis 2) has evolved efficient mechanisms to cause streptococcal toxic shock syndrome (STSS), which is a new emerging infectious disease linked to S. suis. We have previously rep...

    Authors: Qiu Zhong, Yan Zhao, Tian Chen, Supeng Yin, Xinyue Yao, Jing Wang, Shuguang Lu, Yinling Tan, Jiaqi Tang, Beiwen Zheng, Fuquan Hu and Ming Li

    Citation: BMC Microbiology 2014 14:73

    Content type: Research article

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  12. Successful viral infection requires the involvement of host cellular factors in their life cycle. Heat shock protein 70 (HSP70) can be recruited by numerous viruses to promote the folding, maturation, or assem...

    Authors: Jintao Gao, Shuqi Xiao, Xiaohong Liu, Liangliang Wang, Qianqian Ji, Delin Mo and Yaosheng Chen

    Citation: BMC Microbiology 2014 14:64

    Content type: Research article

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  13. Chlamydia trachomatis is an obligate intracellular human pathogen causing ocular and urogenital infections that are a significant clinical and public health concern. This bacterium uses a type III secretion (T3S...

    Authors: Maria da Cunha, Catarina Milho, Filipe Almeida, Sara V Pais, Vítor Borges, Rui Maurício, Maria José Borrego, João Paulo Gomes and Luís Jaime Mota

    Citation: BMC Microbiology 2014 14:40

    Content type: Research article

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  14. The community-associated methicillin-resistant S. aureus (CA-MRSA) ST93 clone is becoming dominant in Australia and is clinically highly virulent. In addition, sepsis and skin infection models demonstrate that ST...

    Authors: Kyra YL Chua, Ian R Monk, Ya-Hsun Lin, Torsten Seemann, Kellie L Tuck, Jessica L Porter, Justin Stepnell, Geoffrey W Coombs, John K Davies, Timothy P Stinear and Benjamin P Howden

    Citation: BMC Microbiology 2014 14:31

    Content type: Research article

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  15. Pyocyanin (PCN), an extracellular product of Pseudomonas aeruginosa and a blue redox active secondary metabolite, plays an important role in invasive pulmonary infection. However, the detailed inflammatory respon...

    Authors: Wenshu Chai, Jia Zhang, Yan Duan, Dianzhu Pan, Wei Liu, Ying Li, Xue Yan and Baiyi Chen

    Citation: BMC Microbiology 2014 14:26

    Content type: Research article

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  16. Burkholderia pseudomallei is the causative agent of melioidosis, a frequently occurring disease in northeastern Thailand, where soil and water high in salt content are common. Using microarray analysis, we previ...

    Authors: Pornpan Pumirat, Usa Boonyuen, Muthita Vanaporn, Peechanika Pinweha, Sarunporn Tandhavanant, Sunee Korbsrisate and Narisara Chantratita

    Citation: BMC Microbiology 2014 14:1

    Content type: Research article

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  17. Probiotics species appear to differentially regulate the intestinal immune response. Moreover, we have shown that different immune-modulatory abilities can be found among probiotic strains belonging to the sam...

    Authors: Diomira Luongo, Junki Miyamoto, Paolo Bergamo, Filomena Nazzaro, Federico Baruzzi, Toshihiro Sashihara, Soichi Tanabe and Mauro Rossi

    Citation: BMC Microbiology 2013 13:298

    Content type: Research article

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  18. Investigating the host response in the early stage of influenza A virus (IAV) infection is of considerable interest. However, it is conceivable that effects due to the anesthesia and/or intranasal infection pr...

    Authors: Matthias Preusse, Mohamed A Tantawy, Frank Klawonn, Klaus Schughart and Frank Pessler

    Citation: BMC Microbiology 2013 13:293

    Content type: Research article

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  19. Inflammatory bowel disease (IBD) involves a breakdown in interactions between the host immune response and the resident commensal microbiota. Recent studies have suggested gut physiology and pathology relevant...

    Authors: Qi He, Lin Wang, Fan Wang, Chenyang Wang, Chun Tang, Qiurong Li, Jieshou Li and Qingshun Zhao

    Citation: BMC Microbiology 2013 13:289

    Content type: Research article

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  20. Recent studies have shown that mammalian milk represents a continuous supply of commensal bacteria, including enterococci. The objectives of this study were to evaluate the presence of enterococci in milk of d...

    Authors: Esther Jiménez, Victor Ladero, Irene Chico, Antonio Maldonado-Barragán, María López, Virginia Martín, Leonides Fernández, María Fernández, Miguel A Álvarez, Carmen Torres and Juan M Rodríguez

    Citation: BMC Microbiology 2013 13:288

    Content type: Research article

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  21. Pseudomonas aeruginosa Vfr (the virulence factor regulator) enhances P. aeruginosa virulence by positively regulating the expression of numerous virulence genes. A previous microarray analysis identified numerous...

    Authors: Aysegul Balyimez, Jane A Colmer-Hamood, Michael San Francisco and Abdul N Hamood

    Citation: BMC Microbiology 2013 13:269

    Content type: Research article

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  22. 3′, 5′cAMP signaling in Sinorhizobium meliloti was recently shown to contribute to the autoregulation of legume infection. In planta, three adenylate cyclases CyaD1, CyaD2 and CyaK, synthesizing 3′, 5′cAMP, toget...

    Authors: Céline Mathieu-Demazière, Véréna Poinsot, Catherine Masson-Boivin, Anne-Marie Garnerone and Jacques Batut

    Citation: BMC Microbiology 2013 13:268

    Content type: Research article

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  23. Arginine is a conditionally essential amino acid important in growing individuals and under non-homeostatic conditions/disease. Many pathogens interfere with arginine-utilization in host cells, especially nitr...

    Authors: Britta Stadelmann, Kurt Hanevik, Mattias K Andersson, Oystein Bruserud and Staffan G Svärd

    Citation: BMC Microbiology 2013 13:256

    Content type: Research article

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  24. Host cell autophagy is implicated in the control of intracellular pathogen. Escherichia coli (E.coli) is the most common organism caused single-germ enterobacterial peritonitis during peritoneal dialysis. In this...

    Authors: Juan Wang, Xiaoran Feng, Youjia Zeng, Jinjin Fan, Juan Wu, Zhijian Li, Xinhui Liu, Rong Huang, Fengxian Huang, Xueqing Yu and Xiao Yang

    Citation: BMC Microbiology 2013 13:255

    Content type: Research article

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  25. Protein PIII is one of the major outer membrane proteins of Neisseria gonorrhoeae, 95% identical to RmpM (reduction modifiable protein M) or class 4 protein of Neisseria meningitidis. RmpM is known to be a membra...

    Authors: Rosanna Leuzzi, Barbara Nesta, Elisabetta Monaci, Elena Cartocci, Laura Serino, Marco Soriani, Rino Rappuoli and Mariagrazia Pizza

    Citation: BMC Microbiology 2013 13:251

    Content type: Research article

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  26. The pathogenic Yersinia species exhibit a primarily extracellular lifestyle through manipulation of host signaling pathways that regulate pro-inflammatory gene expression and cytokine release. To identify host ge...

    Authors: Sofiya N Micheva-Viteva, Yulin Shou, Kristy L Nowak-Lovato, Kirk D Rector and Elizabeth Hong-Geller

    Citation: BMC Microbiology 2013 13:249

    Content type: Research article

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  27. Development of Salmonella enterica serovar Typhimurium (S. Typhimurium) live attenuated vaccine carrier strain to prevent enteric infections has been a subject of intensive study. Several mutants of S. Typhimuriu...

    Authors: Niladri Bhusan Pati, Vikalp Vishwakarma, Sathish kumar Selvaraj, Sabyasachi Dash, Bhaskar Saha, Neera Singh and Mrutyunjay Suar

    Citation: BMC Microbiology 2013 13:236

    Content type: Research article

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  28. Campylobacter jejuni strain 11168 was demonstrated to have a broad specificity for eukaryotic surface glycosylation using glycan array analysis. The initial screen indicated that sialic acid and mannose are impor...

    Authors: Christopher J Day, Greg Tram, Lauren E Hartley-Tassell, Joe Tiralongo and Victoria Korolik

    Citation: BMC Microbiology 2013 13:228

    Content type: Research article

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  29. The cell wall of pathogenic mycobacteria is known to possess poly-L-glutamine (PLG) layer. PLG synthesis has been directly linked to glutamine synthetase (GS) enzyme. glnA1 gene encodes for GS enzyme in mycobacte...

    Authors: Deeksha Tripathi, Harish Chandra and Rakesh Bhatnagar

    Citation: BMC Microbiology 2013 13:226

    Content type: Research article

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  30. Salmonella enterica is a causative agent of foodborne gastroenteritis and the systemic disease known as typhoid fever. This bacterium uses two type three secretion systems (T3SSs) to translocate protein effectors...

    Authors: Colin A Cooper, David T Mulder, Sarah E Allison, Ana Victoria C Pilar and Brian K Coombes

    Citation: BMC Microbiology 2013 13:221

    Content type: Research article

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  31. The adhesion of lactobacilli to the vaginal surface is of paramount importance to develop their probiotic functions. For this reason, the role of HeLa cell surface proteoglycans in the attachment of Lactobacillus...

    Authors: Rebeca Martín, Carla Martín, Susana Escobedo, Juan E Suárez and Luis M Quirós

    Citation: BMC Microbiology 2013 13:210

    Content type: Research article

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  32. Apoptosis is a highly controlled process of cell death that can be induced by periodontopathogens. The present study aimed to investigate the expression of Fas and Bcl-2 proteins by CD3+ T cells in vitro under st...

    Authors: Paulo C Carvalho-Filho, Soraya C Trindade, Teresa Olczak, Geraldo P Sampaio, Milton G Oliveira-Neto, Heidiane A Santos, Bianca F P Pereira, Lilia Moura-Costa, Márcia T Xavier and Roberto Meyer

    Citation: BMC Microbiology 2013 13:206

    Content type: Research article

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  33. Multidrug-resistant (MDR) Salmonella isolates are associated with increased morbidity compared to antibiotic-sensitive strains and are an important health and safety concern in both humans and animals. Salmonella...

    Authors: Brian W Brunelle, Shawn MD Bearson and Bradley L Bearson

    Citation: BMC Microbiology 2013 13:202

    Content type: Research article

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  34. Tuberculosis is one of the leading causes of mortality throughout the world. Mycobacterium tuberculosis, the agent of human tuberculosis, has developed strategies involving proteins and other compounds called vir...

    Authors: Marina Andrea Forrellad, María Verónica Bianco, Federico Carlos Blanco, Javier Nuñez, Laura Inés Klepp, Cristina Lourdes Vazquez, María de la Paz Santangelo, Rosana Valeria Rocha, Marcelo Soria, Paul Golby, Maximiliano Gabriel Gutierrez and Fabiana Bigi

    Citation: BMC Microbiology 2013 13:200

    Content type: Research article

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  35. Enveloped viruses utilize cellular membranes to bud from infected cells. The process of virion assembly and budding is often facilitated by the presence of certain conserved motifs within viral proteins in con...

    Authors: Himanshu Garg, Raphael TC Lee, Ng Oon Tek, Sebastian Maurer-Stroh and Anjali Joshi

    Citation: BMC Microbiology 2013 13:197

    Content type: Research article

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  36. Dengue virus (DENV) infection is the most important arthropod- borne viral disease in human, but antiviral therapy and approved vaccines remain unavailable due to antibody-dependent enhancement (ADE) phenomeno...

    Authors: Ya-Yan Luo, Jun-Jie Feng, Jun-Mei Zhou, Zhi-Zhun Yu, Dan-Yun Fang, Hui-Jun Yan, Gu-Cheng Zeng and Li-Fang Jiang

    Citation: BMC Microbiology 2013 13:194

    Content type: Research article

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  37. Crohn's disease and ulcerative colitis are the major types of chronic inflammatory bowel disease occurring in the colon and small intestine. A growing body of research has proposed that probiotics are able to ...

    Authors: Yi-Heng Chiu, Ying-Chen Lu, Chu-Chyn Ou, Shiao-Lin Lin, Chin-Chi Tsai, Chien-Tsai Huang and Meei-Yn Lin

    Citation: BMC Microbiology 2013 13:190

    Content type: Research article

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  38. Staphylococcus aureus is an opportunistic commensal bacterium that mostly colonizes the skin and soft tissues. The pathogenicity of S. aureus is due to both its ability to resist antibiotics, and the production o...

    Authors: Haziz Sina, Théodora A Ahoyo, Wardi Moussaoui, Daniel Keller, Honoré S Bankolé, Yves Barogui, Ymkje Stienstra, Simeon O Kotchoni, Gilles Prévost and Lamine Baba-Moussa

    Citation: BMC Microbiology 2013 13:188

    Content type: Research article

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  39. Infections caused by extended spectrum beta-lactamases (ESBL)-producing bacteria have been emerging worldwide and the majority of ESBL-producing E. coli strains are isolated from patients with urinary tracts infe...

    Authors: Isak Demirel, Annica Kinnunen, Anna Önnberg, Bo Söderquist and Katarina Persson

    Citation: BMC Microbiology 2013 13:181

    Content type: Research article

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  40. Six independent Gram-negative, facultatively anaerobic, non-spore-forming, nitrogen-fixing rod-shaped isolates were obtained from the root endosphere of rice grown at the International Rice Research Institute ...

    Authors: Pablo Rodrigo Hardoim, Rashid Nazir, Angela Sessitsch, Dana Elhottová, Elisa Korenblum, Leonard Simon van Overbeek and Jan Dirk van Elsas

    Citation: BMC Microbiology 2013 13:164

    Content type: Research article

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  41. Nine gene clusters dedicated to nonribosomal synthesis of secondary metabolites with possible antimicrobial action, including polymyxin and fusaricidin, were detected within the whole genome sequence of the pl...

    Authors: Ben Niu, Joachim Vater, Christian Rueckert, Jochen Blom, Maik Lehmann, Jin-Jiang Ru, Xiao-Hua Chen, Qi Wang and Rainer Borriss

    Citation: BMC Microbiology 2013 13:137

    Content type: Research article

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  42. The RNA binding protein Hfq of Haemophilus influenzae is highly homologous to Hfq from other bacterial species. In many of these other bacteria, Hfq affects the expression of a broad range of genes and enhances t...

    Authors: Randy J Hempel, Daniel J Morton, Thomas W Seale, Paul W Whitby and Terrence L Stull

    Citation: BMC Microbiology 2013 13:134

    Content type: Research article

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  43. The global spread of bacterial resistance has given rise to a growing interest in new anti-bacterial agents with a new strategy of action. Pilicides are derivatives of ring-fused 2-pyridones which block the fo...

    Authors: Rafał Piatek, Beata Zalewska-Piatek, Krystyna Dzierzbicka, Sławomir Makowiec, Justyna Pilipczuk, Kasjan Szemiako, Anna Cyranka-Czaja and Marek Wojciechowski

    Citation: BMC Microbiology 2013 13:131

    Content type: Research article

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  44. Egg defence against bacterial contamination relies on immunoglobulins (IgY) concentrated in the yolk and antimicrobial peptides/proteins predominantly localized in the egg white (EW). Hens contaminated with pa...

    Authors: Larbi Bedrani, Emmanuelle Helloin, Nicolas Guyot, Sophie Réhault-Godbert and Yves Nys

    Citation: BMC Microbiology 2013 13:128

    Content type: Research article

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  45. The Salmonella enterica serovar Typhimurium PhoPQ two component system (TCS) is activated by low Mg2+ levels, low pH and by antimicrobial peptides (AP). Under Mg2+ limitation, the PhoPQ system induces pmrD expres...

    Authors: Lori Johnson, Shawn R Horsman, Laetitia Charron-Mazenod, Amy L Turnbull, Heidi Mulcahy, Michael G Surette and Shawn Lewenza

    Citation: BMC Microbiology 2013 13:115

    Content type: Research article

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  46. Avian influenza remains a serious threat to human health. The consequence of human infection varies markedly among different subtypes of avian influenza viruses. In addition to viral factors, the difference in...

    Authors: Wai-Yip Lam, Apple Chung-Man Yeung, Karry Lei-Ka Ngai, Man-Shan Li, Ka-Fai To, Stephen Kwok-Wing Tsui and Paul Kay-Sheung Chan

    Citation: BMC Microbiology 2013 13:104

    Content type: Research article

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  47. Leishmania parasites are transmitted to their vertebrate hosts by infected Phlebotomine sand flies during the blood meal of the flies. Sand fly saliva is known to enhance Leishmania spp. infection, while pre-expo...

    Authors: Vanessa Carregaro, Diego Luis Costa, Claudia Brodskyn, Aldina Maria Barral, Manuel Barral-Netto, Fernando Q Cunha and João Santana Silva

    Citation: BMC Microbiology 2013 13:102

    Content type: Research article

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