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Microbe-host interactions and microbial pathogenicity

Section edited by David Nelson

This section aims to publish studies looking at all aspects of microbe-host interactions and pathogenicity including pathogenic mechanisms, virulence factors, host invasion, immune evasion, host defence, immunity, immunology and symbiotic interactions.

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  1. Salmonella enterica is a causative agent of foodborne gastroenteritis and the systemic disease known as typhoid fever. This bacterium uses two type three secretion systems (T3SSs) to translocate protein effectors...

    Authors: Colin A Cooper, David T Mulder, Sarah E Allison, Ana Victoria C Pilar and Brian K Coombes

    Citation: BMC Microbiology 2013 13:221

    Content type: Research article

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  2. The adhesion of lactobacilli to the vaginal surface is of paramount importance to develop their probiotic functions. For this reason, the role of HeLa cell surface proteoglycans in the attachment of Lactobacillus...

    Authors: Rebeca Martín, Carla Martín, Susana Escobedo, Juan E Suárez and Luis M Quirós

    Citation: BMC Microbiology 2013 13:210

    Content type: Research article

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  3. Apoptosis is a highly controlled process of cell death that can be induced by periodontopathogens. The present study aimed to investigate the expression of Fas and Bcl-2 proteins by CD3+ T cells in vitro under st...

    Authors: Paulo C Carvalho-Filho, Soraya C Trindade, Teresa Olczak, Geraldo P Sampaio, Milton G Oliveira-Neto, Heidiane A Santos, Bianca F P Pereira, Lilia Moura-Costa, Márcia T Xavier and Roberto Meyer

    Citation: BMC Microbiology 2013 13:206

    Content type: Research article

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  4. Multidrug-resistant (MDR) Salmonella isolates are associated with increased morbidity compared to antibiotic-sensitive strains and are an important health and safety concern in both humans and animals. Salmonella...

    Authors: Brian W Brunelle, Shawn MD Bearson and Bradley L Bearson

    Citation: BMC Microbiology 2013 13:202

    Content type: Research article

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  5. Tuberculosis is one of the leading causes of mortality throughout the world. Mycobacterium tuberculosis, the agent of human tuberculosis, has developed strategies involving proteins and other compounds called vir...

    Authors: Marina Andrea Forrellad, María Verónica Bianco, Federico Carlos Blanco, Javier Nuñez, Laura Inés Klepp, Cristina Lourdes Vazquez, María de la Paz Santangelo, Rosana Valeria Rocha, Marcelo Soria, Paul Golby, Maximiliano Gabriel Gutierrez and Fabiana Bigi

    Citation: BMC Microbiology 2013 13:200

    Content type: Research article

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  6. Enveloped viruses utilize cellular membranes to bud from infected cells. The process of virion assembly and budding is often facilitated by the presence of certain conserved motifs within viral proteins in con...

    Authors: Himanshu Garg, Raphael TC Lee, Ng Oon Tek, Sebastian Maurer-Stroh and Anjali Joshi

    Citation: BMC Microbiology 2013 13:197

    Content type: Research article

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  7. Dengue virus (DENV) infection is the most important arthropod- borne viral disease in human, but antiviral therapy and approved vaccines remain unavailable due to antibody-dependent enhancement (ADE) phenomeno...

    Authors: Ya-Yan Luo, Jun-Jie Feng, Jun-Mei Zhou, Zhi-Zhun Yu, Dan-Yun Fang, Hui-Jun Yan, Gu-Cheng Zeng and Li-Fang Jiang

    Citation: BMC Microbiology 2013 13:194

    Content type: Research article

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  8. Crohn's disease and ulcerative colitis are the major types of chronic inflammatory bowel disease occurring in the colon and small intestine. A growing body of research has proposed that probiotics are able to ...

    Authors: Yi-Heng Chiu, Ying-Chen Lu, Chu-Chyn Ou, Shiao-Lin Lin, Chin-Chi Tsai, Chien-Tsai Huang and Meei-Yn Lin

    Citation: BMC Microbiology 2013 13:190

    Content type: Research article

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  9. Staphylococcus aureus is an opportunistic commensal bacterium that mostly colonizes the skin and soft tissues. The pathogenicity of S. aureus is due to both its ability to resist antibiotics, and the production o...

    Authors: Haziz Sina, Théodora A Ahoyo, Wardi Moussaoui, Daniel Keller, Honoré S Bankolé, Yves Barogui, Ymkje Stienstra, Simeon O Kotchoni, Gilles Prévost and Lamine Baba-Moussa

    Citation: BMC Microbiology 2013 13:188

    Content type: Research article

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  10. Infections caused by extended spectrum beta-lactamases (ESBL)-producing bacteria have been emerging worldwide and the majority of ESBL-producing E. coli strains are isolated from patients with urinary tracts infe...

    Authors: Isak Demirel, Annica Kinnunen, Anna Önnberg, Bo Söderquist and Katarina Persson

    Citation: BMC Microbiology 2013 13:181

    Content type: Research article

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  11. Six independent Gram-negative, facultatively anaerobic, non-spore-forming, nitrogen-fixing rod-shaped isolates were obtained from the root endosphere of rice grown at the International Rice Research Institute ...

    Authors: Pablo Rodrigo Hardoim, Rashid Nazir, Angela Sessitsch, Dana Elhottová, Elisa Korenblum, Leonard Simon van Overbeek and Jan Dirk van Elsas

    Citation: BMC Microbiology 2013 13:164

    Content type: Research article

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  12. Nine gene clusters dedicated to nonribosomal synthesis of secondary metabolites with possible antimicrobial action, including polymyxin and fusaricidin, were detected within the whole genome sequence of the pl...

    Authors: Ben Niu, Joachim Vater, Christian Rueckert, Jochen Blom, Maik Lehmann, Jin-Jiang Ru, Xiao-Hua Chen, Qi Wang and Rainer Borriss

    Citation: BMC Microbiology 2013 13:137

    Content type: Research article

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  13. The RNA binding protein Hfq of Haemophilus influenzae is highly homologous to Hfq from other bacterial species. In many of these other bacteria, Hfq affects the expression of a broad range of genes and enhances t...

    Authors: Randy J Hempel, Daniel J Morton, Thomas W Seale, Paul W Whitby and Terrence L Stull

    Citation: BMC Microbiology 2013 13:134

    Content type: Research article

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  14. The global spread of bacterial resistance has given rise to a growing interest in new anti-bacterial agents with a new strategy of action. Pilicides are derivatives of ring-fused 2-pyridones which block the fo...

    Authors: Rafał Piatek, Beata Zalewska-Piatek, Krystyna Dzierzbicka, Sławomir Makowiec, Justyna Pilipczuk, Kasjan Szemiako, Anna Cyranka-Czaja and Marek Wojciechowski

    Citation: BMC Microbiology 2013 13:131

    Content type: Research article

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  15. Egg defence against bacterial contamination relies on immunoglobulins (IgY) concentrated in the yolk and antimicrobial peptides/proteins predominantly localized in the egg white (EW). Hens contaminated with pa...

    Authors: Larbi Bedrani, Emmanuelle Helloin, Nicolas Guyot, Sophie Réhault-Godbert and Yves Nys

    Citation: BMC Microbiology 2013 13:128

    Content type: Research article

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  16. The Salmonella enterica serovar Typhimurium PhoPQ two component system (TCS) is activated by low Mg2+ levels, low pH and by antimicrobial peptides (AP). Under Mg2+ limitation, the PhoPQ system induces pmrD expres...

    Authors: Lori Johnson, Shawn R Horsman, Laetitia Charron-Mazenod, Amy L Turnbull, Heidi Mulcahy, Michael G Surette and Shawn Lewenza

    Citation: BMC Microbiology 2013 13:115

    Content type: Research article

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  17. Avian influenza remains a serious threat to human health. The consequence of human infection varies markedly among different subtypes of avian influenza viruses. In addition to viral factors, the difference in...

    Authors: Wai-Yip Lam, Apple Chung-Man Yeung, Karry Lei-Ka Ngai, Man-Shan Li, Ka-Fai To, Stephen Kwok-Wing Tsui and Paul Kay-Sheung Chan

    Citation: BMC Microbiology 2013 13:104

    Content type: Research article

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  18. Leishmania parasites are transmitted to their vertebrate hosts by infected Phlebotomine sand flies during the blood meal of the flies. Sand fly saliva is known to enhance Leishmania spp. infection, while pre-expo...

    Authors: Vanessa Carregaro, Diego Luis Costa, Claudia Brodskyn, Aldina Maria Barral, Manuel Barral-Netto, Fernando Q Cunha and João Santana Silva

    Citation: BMC Microbiology 2013 13:102

    Content type: Research article

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  19. Lyme borreliosis, caused by tick-borne Borrelia burgdorferi, is a multi-phasic, multi-system disease in humans. Similar to humans, C3H mice develop arthritis and carditis, with resolution and periodic bouts of re...

    Authors: Denise Imai, Kevin Holden, Eric M Velazquez, Sunlian Feng, Emir Hodzic and Stephen W Barthold

    Citation: BMC Microbiology 2013 13:100

    Content type: Research article

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  20. Many Gram-negative bacteria rely on a type VI secretion system (T6SS) to infect eukaryotic cells or to compete against other microbes. Common to these systems is the presence of two conserved proteins, in Vibrio ...

    Authors: Jeanette E Bröms, Takahiko Ishikawa, Sun N Wai and Anders Sjöstedt

    Citation: BMC Microbiology 2013 13:96

    Content type: Research article

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  21. Microcin J25 (MccJ25) is a plasmid-encoded antibiotic peptide produced by Escherichia coli (E. coli). MccJ25 enters into the sensitive E. coli strains by the outer membrane receptor FhuA and the inner membrane pr...

    Authors: María Fernanda Pomares, Natalia S Corbalán, Conrado Adler, Ricardo de Cristóbal, Ricardo N Farías, Mónica A Delgado and Paula A Vincent

    Citation: BMC Microbiology 2013 13:95

    Content type: Research article

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  22. The bacterial surface protein internalin (InlA) is a major virulence factor of the food-born pathogen Listeria monocytogenes. It plays a critical role in the bacteria crossing the host intestinal barrier by a spe...

    Authors: Silke Bergmann, Philippa M Beard, Bastian Pasche, Stefan Lienenklaus, Siegfried Weiss, Cormac G M Gahan, Klaus Schughart and Andreas Lengeling

    Citation: BMC Microbiology 2013 13:90

    Content type: Research article

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  23. Low temperatures play key roles in the development of most plant diseases, mainly because of their influence on the expression of various virulence factors in phytopathogenic bacteria. Thus far, studies regard...

    Authors: Jackeline Lizzeta Arvizu-Gómez, Alejandro Hernández-Morales, Juan Ramiro Pacheco Aguilar and Ariel Álvarez-Morales

    Citation: BMC Microbiology 2013 13:81

    Content type: Research article

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  24. Pseudomonas aeruginosa is an important opportunistic human pathogen and is extremely difficult to treat due to its high intrinsic and adaptive antibiotic resistance, ability to form biofilms in chronic infections...

    Authors: Anke Neidig, Amy TY Yeung, Thibaut Rosay, Beatrix Tettmann, Nikola Strempel, Martina Rueger, Olivier Lesouhaitier and Joerg Overhage

    Citation: BMC Microbiology 2013 13:77

    Content type: Research article

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  25. Porphyromonas gingivalis lipopolysaccharide (LPS) is a crucial virulence factor strongly associated with chronic periodontitis which is the primary cause of tooth loss in adults. It exhibits remarkable heterogene...

    Authors: Thanuja D K Herath, Yu Wang, Chaminda J Seneviratne, Richard P Darveau, Cun-Yu Wang and Lijian Jin

    Citation: BMC Microbiology 2013 13:73

    Content type: Research article

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  26. The importance of flagella and chemotaxis genes in host pathogen interaction in Salmonella enterica is mainly based on studies of the broad host range serovar, S. Typhimurium, while little is known on the importa...

    Authors: John Elmerdahl Olsen, Kirsten Hobolt Hoegh-Andersen, Josep Casadesús, Jesper T Rosenkrantz, Mark Simon Chadfield and Line Elnif Thomsen

    Citation: BMC Microbiology 2013 13:67

    Content type: Research article

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  27. Previously, a bovine intestinal epithelial cell line (BIE cells) was successfully established. This work hypothesized that BIE cells are useful in vitro model system for the study of interactions of microbial-...

    Authors: Naoya Takanashi, Yohsuke Tomosada, Julio Villena, Kozue Murata, Takuya Takahashi, Eriko Chiba, Masanori Tohno, Tomoyuki Shimazu, Hisashi Aso, Yoshihito Suda, Shuji Ikegami, Hiroyuki Itoh, Yasushi Kawai, Tadao Saito, Susana Alvarez and Haruki Kitazawa

    Citation: BMC Microbiology 2013 13:54

    Content type: Research article

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  28. The life cycle of a bacteriophage has tightly programmed steps to help virus infect its host through the interactions between the bacteriophage and its host proteins. However, bacteriophage–host protein intera...

    Authors: Yanjiang Chen, Dahai Wei, Yiqian Wang and Xiaobo Zhang

    Citation: BMC Microbiology 2013 13:48

    Content type: Research article

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  29. Bacterial signal transduction systems like two component system (TCS) and Serine/Threonine kinase (STK) and Serine/Threonine phosphatase (STP) play important roles in the virulence and pathogenesis of bacteria...

    Authors: Mario A Martinez, Kishore Das, Sankaralingam Saikolappan, Luis A Materon and Subramanian Dhandayuthapani

    Citation: BMC Microbiology 2013 13:44

    Content type: Research article

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  30. All Shigella flexneri serotypes except serotype 6 share a common O-antigen tetrasaccharide backbone and nearly all variations between serotypes are due to glucosyl and/or O-acetyl modifications of the common O un...

    Authors: Qiangzheng Sun, Ruiting Lan, Yiting Wang, Jianping Wang, Yan Wang, Peijing Li, Pengcheng Du and Jianguo Xu

    Citation: BMC Microbiology 2013 13:39

    Content type: Research article

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  31. Cronobacter spp. are opportunistic pathogens that can cause septicemia and infections of the central nervous system primarily in premature, low-birth weight and/or immune-compromised neonates. Serum resistance is...

    Authors: Sarah Schwizer, Taurai Tasara, Katrin Zurfluh, Roger Stephan and Angelika Lehner

    Citation: BMC Microbiology 2013 13:38

    Content type: Research article

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  32. Shigella is a major pathogen responsible for bacillary dysentery, a severe form of shigellosis. Severity of the disease depends on the virulence of the infecting strain. Shigella pathogenicity is a multi-gene phe...

    Authors: Junqi Zhang, Lisheng Qian, Yang Wu, Xia Cai, Xueping Li, Xunjia Cheng and Di Qu

    Citation: BMC Microbiology 2013 13:31

    Content type: Research article

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  33. Diffusely adherent Escherichia coli (DAEC) have been considered a diarrheagenic category of E. coli for which several potential virulence factors have been described in the last few years. Despite this, epidemiol...

    Authors: Rosane Mansan-Almeida, Alex Leite Pereira and Loreny Gimenes Giugliano

    Citation: BMC Microbiology 2013 13:22

    Content type: Research article

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  34. A prerequisite for the virulence of the facultative intracellular bacterium Francisella tularensis is effective intramacrophage proliferation, which is preceded by phagosomal escape into the cytosol, and ultimate...

    Authors: Marie Lindgren, Jeanette E Bröms, Lena Meyer, Igor Golovliov and Anders Sjöstedt

    Citation: BMC Microbiology 2013 13:20

    Content type: Research article

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  35. MAP is a suspected zoonotic pathogen and the causative agent of Johne’s Disease in cattle and other ruminant animals. With over $1 billion dollars in loss to the dairy industry due to Johne’s Disease, efforts ...

    Authors: Enusha Karunasena, Paresh C Kurkure, Russell D Lackey, Kevin Wyatt McMahon, Estevan P Kiernan, Suzanne Graham, Magdy S Alabady, David L Campos, Owatha L Tatum and Mindy M Brashears

    Citation: BMC Microbiology 2013 13:8

    Content type: Research article

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  36. Chronic periodontitis is an infectious disease of the periodontium, which includes the gingival epithelium, periodontal ligament and alveolar bone. The signature clinical feature of periodontitis is resorption...

    Authors: Wenjian Zhang, Jun Ju, Todd Rigney and Gena Tribble

    Citation: BMC Microbiology 2013 13:5

    Content type: Research article

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  37. Studies with the nematode model Caenorhabditis elegans have identified conserved biochemical pathways that act to modulate life span. Life span can also be influenced by the composition of the intestinal microbio...

    Authors: Fernando Gomez, Gabriela C Monsalve, Vincent Tse, Ryoichi Saiki, Emily Weng, Laura Lee, Chandra Srinivasan, Alison R Frand and Catherine F Clarke

    Citation: BMC Microbiology 2012 12:300

    Content type: Research article

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  38. Toxin complex (Tc) family proteins were first identified as insecticidal toxins in Photorhabdus luminescens and have since been found in a wide range of bacteria. The genome of Yersinia pestis, the causative agen...

    Authors: Justin L Spinner, Clayton O Jarrett, Doris L LaRock, Samuel I Miller, Carleen M Collins and B Joseph Hinnebusch

    Citation: BMC Microbiology 2012 12:296

    Content type: Research article

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  39. Burkholderia pseudomallei and B. mallei are closely related Category B Select Agents of bioterrorism and the causative agents of the diseases melioidosis and glanders, respectively. Rapid phage-based diagnostic t...

    Authors: Brian H Kvitko, Christopher R Cox, David DeShazer, Shannon L Johnson, Kent J Voorhees and Herbert P Schweizer

    Citation: BMC Microbiology 2012 12:289

    Content type: Research article

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  40. Candida albicans is a human fungal pathogen, able to cause both superficial and serious, systemic diseases and is able to switch from yeast cells to long, tube-like hyphae, depending on the prevailing environment...

    Authors: Ekaterina S Ovchinnikova, Bastiaan P Krom, Henk J Busscher and Henny C van der Mei

    Citation: BMC Microbiology 2012 12:281

    Content type: Research article

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  41. Staphylococcus aureus strains with distinct genetic backgrounds have shown different virulence in animal models as well as associations with different clinical outcomes, such as causing infection in the hospital ...

    Authors: Kaiyu Wu, John Conly, Michael Surette, Christopher Sibley, Sameer Elsayed and Kunyan Zhang

    Citation: BMC Microbiology 2012 12:274

    Content type: Research article

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  42. Prophages of enteric bacteria are frequently of key importance for the biology, virulence, or host adaptation of their host. Some C. jejuni isolates carry homologs of the CJIE1 (CMLP 1) prophage that carry cargo ...

    Authors: Clifford G Clark, Christopher CR Grant, Frank Pollari, Barbara Marshall 3, Jason Moses, Dobryan M Tracz and Matthew W Gilmour

    Citation: BMC Microbiology 2012 12:269

    Content type: Research article

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  43. The morphogenesis of herpes simplex virus type 1 (HSV-1) comprises several events, of which some are not completely understood. It has been shown that HSV-1 glycoproteins accumulate in the trans-Golgi network (TG...

    Authors: Raquel Bello-Morales, Antonio Jesús Crespillo, Alberto Fraile-Ramos, Enrique Tabarés, Antonio Alcina and José Antonio López-Guerrero

    Citation: BMC Microbiology 2012 12:265

    Content type: Research article

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  44. Nontypeable Haemophilus influenzae (NTHi) is a significant human pathogen responsible for respiratory tract infections and the most common cause of recurrent otitis media. Type II toxin-antitoxin (TA) systems are...

    Authors: Dabin Ren, Anna N Walker and Dayle A Daines

    Citation: BMC Microbiology 2012 12:263

    Content type: Research article

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  45. The genetic features that facilitate Campylobacter jejuni’s adaptation to a wide range of environments are not completely defined. However, whole genome expression studies showed that respiratory proteins (RPs) w...

    Authors: Issmat I Kassem, Mahesh Khatri, Malak A Esseili, Yasser M Sanad, Yehia M Saif, Jonathan W Olson and Gireesh Rajashekara

    Citation: BMC Microbiology 2012 12:258

    Content type: Research article

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  46. The classical roles of B cells include the production of antibodies and cytokines and the generation of immunological memory, these being key factors in the adaptive immune response. However, their role in inn...

    Authors: Blanca Estela García-Pérez, Juan José De la Cruz-López, Jorge Ismael Castañeda-Sánchez, Ana Rosa Muñóz-Duarte, Alma Delia Hernández-Pérez, Hilda Villegas-Castrejón, Ethel García-Latorre, Angel Caamal-Ley and Julieta Luna-Herrera

    Citation: BMC Microbiology 2012 12:246

    Content type: Research article

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  47. Efficient perception of attacking pathogens is essential for plants. Plant defense is evoked by molecules termed elicitors. Endogenous elicitors or damage-associated molecular patterns (DAMPs) originate from p...

    Authors: Frank-Jörg Vorhölter, Heinrich-Günter Wiggerich, Heiko Scheidle, Vishaldeep Kaur Sidhu, Kalina Mrozek, Helge Küster, Alfred Pühler and Karsten Niehaus

    Citation: BMC Microbiology 2012 12:239

    Content type: Research article

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  48. Enterohemorrhagic Escherichia coli (EHEC) colonizes the intestinal epithelium and causes attaching and effacing (A/E) lesions. Expression of virulence genes, particularly those from the locus of the enterocyte ef...

    Authors: Anne-Marie Hansen and Ding Jun Jin

    Citation: BMC Microbiology 2012 12:231

    Content type: Research article

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