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Microbe-host interactions and microbial pathogenicity

Section edited by David Nelson

This section aims to publish studies looking at all aspects of microbe-host interactions and pathogenicity including pathogenic mechanisms, virulence factors, host invasion, immune evasion, host defence, immunity, immunology and symbiotic interactions.

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  1. Caseous lymphadenitis (CL) is a contagious infectious disease of small ruminants caused by Corynebacterium pseudotuberculosis. Is characterized by the formation of abscesses in the lymph nodes and intestines of i...

    Authors: Andréia Pacheco de Souza, Vera Lúcia Costa Vale, Marcos da Costa Silva, Inara Barbosa de Oliveira Araújo, Soraya Castro Trindade, Lília Ferreira de Moura-Costa, Gabriele Costa Rodrigues, Tatiane Santana Sales, Heidiane Alves dos Santos, Paulo Cirino de Carvalho-Filho, Milton Galdino de Oliveira-Neto, Robert Eduard Schaer and Roberto Meyer

    Citation: BMC Microbiology 2014 14:230

    Content type: Research article

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  2. Several intracellular bacterial pathogens have evolved subtle strategies to subvert vesicular trafficking pathways of their host cells to avoid killing and to replicate inside the cells. Brucellae are Gram-negati...

    Authors: Isabelle Hamer, Emeline Goffin, Xavier De Bolle, Jean-Jacques Letesson and Michel Jadot

    Citation: BMC Microbiology 2014 14:223

    Content type: Research article

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  3. Analysis of the Escherichia coli collection of reference strains (ECOR) for the presence of the gene locus clyA, which encodes the pore-forming protein ClyA (cytolysin A), revealed that a non-functional clyA locu...

    Authors: Constance Oben Ayuk Enow, Jan Oscarsson, Nikola Zlatkov, Marie Westermark, Marylise Duperthuy, Sun Nyunt Wai and Bernt Eric Uhlin

    Citation: BMC Microbiology 2014 14:216

    Content type: Research article

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  4. Chlamydia trachomatis is an intracellular bacteria which consist of three biovariants; trachoma (serovars A-C), urogenital (serovars D-K) and lymphogranuloma venereum (L1-L3), causing a wide spectrum of disease ...

    Authors: Baishakhi Datta, Florence Njau, Jessica Thalmann, Hermann Haller and Annette D Wagner

    Citation: BMC Microbiology 2014 14:209

    Content type: Research article

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  5. The ability of S. pneumoniae to generate infections depends on the restrictions imposed by the host’s immunity, in order to prevent the bacterium from spreading from the nasopharynx to other tissues, such as the ...

    Authors: Hugo Macedo-Ramos, Andre F Batista, Alvaro Carrier-Ruiz, Lucineia Alves, Silvana Allodi, Victor T Ribeiro-Resende, Lucia M Teixeira and Wagner Baetas-da-Cruz

    Citation: BMC Microbiology 2014 14:211

    Content type: Research article

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  6. Burkholderia pseudomallei is a facultative intracellular pathogen and the causative agent of melioidosis. A conserved type III secretion system (T3SS3) and type VI secretion system (T6SS1) are critical for intra...

    Authors: Yahua Chen, Imke Schröder, Christopher T French, Artur Jaroszewicz, Xiao Jie Yee, Boon-Eng Teh, Isabelle J Toesca, Jeff F Miller and Yunn-Hwen Gan

    Citation: BMC Microbiology 2014 14:206

    Content type: Research article

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  7. The microbiota of the mammalian gastrointestinal (GI) tract consists of diverse populations of commensal bacteria that interact with host physiological function. Dysregulating these populations, through exogen...

    Authors: Jeffrey D Galley, Michael C Nelson, Zhongtang Yu, Scot E Dowd, Jens Walter, Purnima S Kumar, Mark Lyte and Michael T Bailey

    Citation: BMC Microbiology 2014 14:189

    Content type: Research article

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  8. Host signals are being shown to have a major impact on the bacterial phenotype. One of them is the endogenously produced catecholamine stress hormones, which are also used therapeutically as inotropes. Recent ...

    Authors: Sara Sandrini, Fayez Alghofaili, Primrose Freestone and Hasan Yesilkaya

    Citation: BMC Microbiology 2014 14:180

    Content type: Research article

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  9. Clostridium difficile is the main cause of hospital-acquired diarrhea and colitis known as C. difficile-associated disease (CDAD).With increased severity and failure of treatment in CDAD, new approaches for prev...

    Authors: Prapaporn Boonma, Jennifer K Spinler, Susan F Venable, James Versalovic and Somying Tumwasorn

    Citation: BMC Microbiology 2014 14:177

    Content type: Research article

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  10. Flavobacterium columnare (Bacteroidetes) is the causative agent of columnaris disease in farmed freshwater fish around the world. The bacterium forms three colony morphotypes (Rhizoid, Rough and Soft), but the d...

    Authors: Elina Laanto, Reetta K Penttinen, Jaana KH Bamford and Lotta-Riina Sundberg

    Citation: BMC Microbiology 2014 14:170

    Content type: Research article

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  11. Bacterial lipoproteins often play important roles in pathogenesis and can stimulate protective immune responses. Such lipoproteins are viable vaccine candidates. Haemophilus ducreyi, which causes the sexually tra...

    Authors: Diane M Janowicz, Beth W Zwickl, Kate R Fortney, Barry P Katz and Margaret E Bauer

    Citation: BMC Microbiology 2014 14:166

    Content type: Research article

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  12. Mycoplasma pneumoniae is one of the causative organisms of community-acquired pneumonia which is found commonly in younger patients. Extrapulmonary complications similar to autoimmune disease are caused by M. pn...

    Authors: Satoshi Kurata, Takako Osaki, Hideo Yonezawa, Ken Arae, Haruhiko Taguchi and Shigeru Kamiya

    Citation: BMC Microbiology 2014 14:156

    Content type: Research article

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  13. Community-acquired, methicillin-resistant Staphylococcus aureus strains often cause localized infections in immunocompromised hosts, but some strains show enhanced virulence leading to severe infections even amon...

    Authors: Gyan S Sahukhal and Mohamed O Elasri

    Citation: BMC Microbiology 2014 14:154

    Content type: Research article

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  14. Leishmania amazonensis infection results in diverse clinical manifestations: cutaneous, mucocutaneous or visceral leishmaniasis. The arsenal of drugs available for treating Leishmania infections is limited. Ther...

    Authors: Tatiana Shioji Tiuman, Tânia Ueda-Nakamura, Antonio Alonso and Celso Vataru Nakamura

    Citation: BMC Microbiology 2014 14:152

    Content type: Research article

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  15. Zinc supplements can treat or prevent enteric infections and diarrheal disease. Many articles on zinc in bacteria, however, highlight the essential nature of this metal for bacterial growth and virulence, sugg...

    Authors: John K Crane, Jackie E Broome, Ryan M Reddinger and Benjamin B Werth

    Citation: BMC Microbiology 2014 14:145

    Content type: Research article

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  16. Campylobacter jejuni (C. jejuni) is the leading causative agent of bacterial gastrointestinal infections. The rise of antibiotic resistant forms of this pathogen necessitates the development of novel interventio...

    Authors: Sona Rubinchik, Alan M Seddon and Andrey V Karlyshev

    Citation: BMC Microbiology 2014 14:141

    Content type: Research article

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  17. Epidemiological studies relate influenza infection with vascular diseases like myocardial infarction. The hypothesis that influenza infection has procoagulant effects on humans has been investigated by experim...

    Authors: Marco Goeijenbier, Eric CM van Gorp, Judith MA Van den Brand, Koert Stittelaar, Kamran Bakhtiari, Joris JTH Roelofs, Geert van Amerongen, Thijs Kuiken, Byron EE Martina, Joost CM Meijers and Albert DME Osterhaus

    Citation: BMC Microbiology 2014 14:134

    Content type: Research article

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  18. Recent scientific developments have shed more light on the importance of the host-microbe interaction, particularly in the gut. However, the mechanistic study of the host-microbe interplay is complicated by th...

    Authors: Massimo Marzorati, Barbara Vanhoecke, Tine De Ryck, Mehdi Sadaghian Sadabad, Iris Pinheiro, Sam Possemiers, Pieter Van den Abbeele, Lara Derycke, Marc Bracke, Jan Pieters, Tom Hennebel, Hermie J Harmsen, Willy Verstraete and Tom Van de Wiele

    Citation: BMC Microbiology 2014 14:133

    Content type: Methodology article

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  19. Phospholipases C (PLCs) are virulence factors found in several bacteria. In Mycobacterium tuberculosis (Mtb) they exhibit cytotoxic effects on macrophages, but the mechanisms involved in PLC-induced cell death ar...

    Authors: Patricia A Assis, Milena S Espíndola, Francisco WG Paula-Silva, Wendy M Rios, Priscilla AT Pereira, Sylvia C Leão, Célio L Silva and Lúcia H Faccioli

    Citation: BMC Microbiology 2014 14:128

    Content type: Research article

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  20. Previous findings suggested that Lactobacillus rhamnosus CRL1505 is able to increase resistance of children to intestinal viral infections. However, the intestinal cells, cytokines and receptors involved in the i...

    Authors: Julio Villena, Eriko Chiba, Maria Guadalupe Vizoso-Pinto, Yohsuke Tomosada, Takuya Takahashi, Takamasa Ishizuka, Hisashi Aso, Susana Salva, Susana Alvarez and Haruki Kitazawa

    Citation: BMC Microbiology 2014 14:126

    Content type: Research article

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  21. Burkholderia pseudomallei is the causative agent of melioidosis, a potentially fatal disease endemic in Southeast Asia and Northern Australia. This Gram-negative pathogen possesses numerous virulence factors inc...

    Authors: Boon Eng Teh, Christopher Todd French, Yahua Chen, Isabelle Gek Joo Chen, Ting-Hsiang Wu, Enrico Sagullo, Pei-Yu Chiou, Michael A Teitell, Jeff F Miller and Yunn-Hwen Gan

    Citation: BMC Microbiology 2014 14:115

    Content type: Research article

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  22. Burkholderia pseudomallei (Bp), a Gram-negative, motile, facultative intracellular bacterium is the causative agent of melioidosis in humans and animals. The Bp genome encodes a repertoire of virulence factors, ...

    Authors: Gianluca Pegoraro, Brett P Eaton, Ricky L Ulrich, Douglas J Lane, Jenifer F Ojeda, Sina Bavari, David DeShazer and Rekha G Panchal

    Citation: BMC Microbiology 2014 14:98

    Content type: Methodology article

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  23. Several bacterial plant pathogens colonize their hosts through the secretion of effector proteins by a Type III protein secretion system (T3SS). The role of T3SS in bacterial pathogenesis is well established b...

    Authors: Tamara Zimaro, Ludivine Thomas, Claudius Marondedze, Germán G Sgro, Cecilia G Garofalo, Florencia A Ficarra, Chris Gehring, Jorgelina Ottado and Natalia Gottig

    Citation: BMC Microbiology 2014 14:96

    Content type: Research article

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  24. Autotransporters form a large family of outer membrane proteins specifying diverse biological traits of Gram-negative bacteria. In this study, we report the identification and characterization of a novel autot...

    Authors: Eric R Lafontaine, Rachel Balder, Frank Michel and Robert J Hogan

    Citation: BMC Microbiology 2014 14:92

    Content type: Research article

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  25. Human influenza virus hemagglutinin prefers to use sialic acid (SA) receptors via α-2,6 linkages. The β-galactoside α-2,6-sialyltransferase I (ST6Gal I) protein is encoded by the ST6GAL1 gene and is responsibl...

    Authors: Dong Wu, Wenbo Huang, Yutao Wang, Wenda Guan, Runfeng Li, Zifeng Yang and Nanshan Zhong

    Citation: BMC Microbiology 2014 14:78

    Content type: Research article

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  26. Toxoplasma gondii hijacks host cells to allow it to disseminate throughout a host animal; however, the migratory machinery involved in this process has not been well characterized. We examined the functional rol...

    Authors: Hany M Ibrahim, Maki Nishimura, Sachi Tanaka, Walaa Awadin, Hidefumi Furuoka, Xuenan Xuan and Yoshifumi Nishikawa

    Citation: BMC Microbiology 2014 14:76

    Content type: Research article

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  27. Streptococcus suis serotype 2 (S. suis 2) has evolved efficient mechanisms to cause streptococcal toxic shock syndrome (STSS), which is a new emerging infectious disease linked to S. suis. We have previously rep...

    Authors: Qiu Zhong, Yan Zhao, Tian Chen, Supeng Yin, Xinyue Yao, Jing Wang, Shuguang Lu, Yinling Tan, Jiaqi Tang, Beiwen Zheng, Fuquan Hu and Ming Li

    Citation: BMC Microbiology 2014 14:73

    Content type: Research article

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  28. Successful viral infection requires the involvement of host cellular factors in their life cycle. Heat shock protein 70 (HSP70) can be recruited by numerous viruses to promote the folding, maturation, or assem...

    Authors: Jintao Gao, Shuqi Xiao, Xiaohong Liu, Liangliang Wang, Qianqian Ji, Delin Mo and Yaosheng Chen

    Citation: BMC Microbiology 2014 14:64

    Content type: Research article

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  29. Chlamydia trachomatis is an obligate intracellular human pathogen causing ocular and urogenital infections that are a significant clinical and public health concern. This bacterium uses a type III secretion (T3S...

    Authors: Maria da Cunha, Catarina Milho, Filipe Almeida, Sara V Pais, Vítor Borges, Rui Maurício, Maria José Borrego, João Paulo Gomes and Luís Jaime Mota

    Citation: BMC Microbiology 2014 14:40

    Content type: Research article

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  30. The community-associated methicillin-resistant S. aureus (CA-MRSA) ST93 clone is becoming dominant in Australia and is clinically highly virulent. In addition, sepsis and skin infection models demonstrate that ST...

    Authors: Kyra YL Chua, Ian R Monk, Ya-Hsun Lin, Torsten Seemann, Kellie L Tuck, Jessica L Porter, Justin Stepnell, Geoffrey W Coombs, John K Davies, Timothy P Stinear and Benjamin P Howden

    Citation: BMC Microbiology 2014 14:31

    Content type: Research article

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  31. Pyocyanin (PCN), an extracellular product of Pseudomonas aeruginosa and a blue redox active secondary metabolite, plays an important role in invasive pulmonary infection. However, the detailed inflammatory respon...

    Authors: Wenshu Chai, Jia Zhang, Yan Duan, Dianzhu Pan, Wei Liu, Ying Li, Xue Yan and Baiyi Chen

    Citation: BMC Microbiology 2014 14:26

    Content type: Research article

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  32. Burkholderia pseudomallei is the causative agent of melioidosis, a frequently occurring disease in northeastern Thailand, where soil and water high in salt content are common. Using microarray analysis, we previ...

    Authors: Pornpan Pumirat, Usa Boonyuen, Muthita Vanaporn, Peechanika Pinweha, Sarunporn Tandhavanant, Sunee Korbsrisate and Narisara Chantratita

    Citation: BMC Microbiology 2014 14:1

    Content type: Research article

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  33. Probiotics species appear to differentially regulate the intestinal immune response. Moreover, we have shown that different immune-modulatory abilities can be found among probiotic strains belonging to the sam...

    Authors: Diomira Luongo, Junki Miyamoto, Paolo Bergamo, Filomena Nazzaro, Federico Baruzzi, Toshihiro Sashihara, Soichi Tanabe and Mauro Rossi

    Citation: BMC Microbiology 2013 13:298

    Content type: Research article

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  34. Investigating the host response in the early stage of influenza A virus (IAV) infection is of considerable interest. However, it is conceivable that effects due to the anesthesia and/or intranasal infection pr...

    Authors: Matthias Preusse, Mohamed A Tantawy, Frank Klawonn, Klaus Schughart and Frank Pessler

    Citation: BMC Microbiology 2013 13:293

    Content type: Research article

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  35. Inflammatory bowel disease (IBD) involves a breakdown in interactions between the host immune response and the resident commensal microbiota. Recent studies have suggested gut physiology and pathology relevant...

    Authors: Qi He, Lin Wang, Fan Wang, Chenyang Wang, Chun Tang, Qiurong Li, Jieshou Li and Qingshun Zhao

    Citation: BMC Microbiology 2013 13:289

    Content type: Research article

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  36. Recent studies have shown that mammalian milk represents a continuous supply of commensal bacteria, including enterococci. The objectives of this study were to evaluate the presence of enterococci in milk of d...

    Authors: Esther Jiménez, Victor Ladero, Irene Chico, Antonio Maldonado-Barragán, María López, Virginia Martín, Leonides Fernández, María Fernández, Miguel A Álvarez, Carmen Torres and Juan M Rodríguez

    Citation: BMC Microbiology 2013 13:288

    Content type: Research article

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  37. Pseudomonas aeruginosa Vfr (the virulence factor regulator) enhances P. aeruginosa virulence by positively regulating the expression of numerous virulence genes. A previous microarray analysis identified numerous...

    Authors: Aysegul Balyimez, Jane A Colmer-Hamood, Michael San Francisco and Abdul N Hamood

    Citation: BMC Microbiology 2013 13:269

    Content type: Research article

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  38. 3′, 5′cAMP signaling in Sinorhizobium meliloti was recently shown to contribute to the autoregulation of legume infection. In planta, three adenylate cyclases CyaD1, CyaD2 and CyaK, synthesizing 3′, 5′cAMP, toget...

    Authors: Céline Mathieu-Demazière, Véréna Poinsot, Catherine Masson-Boivin, Anne-Marie Garnerone and Jacques Batut

    Citation: BMC Microbiology 2013 13:268

    Content type: Research article

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  39. Arginine is a conditionally essential amino acid important in growing individuals and under non-homeostatic conditions/disease. Many pathogens interfere with arginine-utilization in host cells, especially nitr...

    Authors: Britta Stadelmann, Kurt Hanevik, Mattias K Andersson, Oystein Bruserud and Staffan G Svärd

    Citation: BMC Microbiology 2013 13:256

    Content type: Research article

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  40. Host cell autophagy is implicated in the control of intracellular pathogen. Escherichia coli (E.coli) is the most common organism caused single-germ enterobacterial peritonitis during peritoneal dialysis. In this...

    Authors: Juan Wang, Xiaoran Feng, Youjia Zeng, Jinjin Fan, Juan Wu, Zhijian Li, Xinhui Liu, Rong Huang, Fengxian Huang, Xueqing Yu and Xiao Yang

    Citation: BMC Microbiology 2013 13:255

    Content type: Research article

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  41. Protein PIII is one of the major outer membrane proteins of Neisseria gonorrhoeae, 95% identical to RmpM (reduction modifiable protein M) or class 4 protein of Neisseria meningitidis. RmpM is known to be a membra...

    Authors: Rosanna Leuzzi, Barbara Nesta, Elisabetta Monaci, Elena Cartocci, Laura Serino, Marco Soriani, Rino Rappuoli and Mariagrazia Pizza

    Citation: BMC Microbiology 2013 13:251

    Content type: Research article

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  42. The pathogenic Yersinia species exhibit a primarily extracellular lifestyle through manipulation of host signaling pathways that regulate pro-inflammatory gene expression and cytokine release. To identify host ge...

    Authors: Sofiya N Micheva-Viteva, Yulin Shou, Kristy L Nowak-Lovato, Kirk D Rector and Elizabeth Hong-Geller

    Citation: BMC Microbiology 2013 13:249

    Content type: Research article

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  43. Development of Salmonella enterica serovar Typhimurium (S. Typhimurium) live attenuated vaccine carrier strain to prevent enteric infections has been a subject of intensive study. Several mutants of S. Typhimuriu...

    Authors: Niladri Bhusan Pati, Vikalp Vishwakarma, Sathish kumar Selvaraj, Sabyasachi Dash, Bhaskar Saha, Neera Singh and Mrutyunjay Suar

    Citation: BMC Microbiology 2013 13:236

    Content type: Research article

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  44. Campylobacter jejuni strain 11168 was demonstrated to have a broad specificity for eukaryotic surface glycosylation using glycan array analysis. The initial screen indicated that sialic acid and mannose are impor...

    Authors: Christopher J Day, Greg Tram, Lauren E Hartley-Tassell, Joe Tiralongo and Victoria Korolik

    Citation: BMC Microbiology 2013 13:228

    Content type: Research article

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  45. The cell wall of pathogenic mycobacteria is known to possess poly-L-glutamine (PLG) layer. PLG synthesis has been directly linked to glutamine synthetase (GS) enzyme. glnA1 gene encodes for GS enzyme in mycobacte...

    Authors: Deeksha Tripathi, Harish Chandra and Rakesh Bhatnagar

    Citation: BMC Microbiology 2013 13:226

    Content type: Research article

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  46. Salmonella enterica is a causative agent of foodborne gastroenteritis and the systemic disease known as typhoid fever. This bacterium uses two type three secretion systems (T3SSs) to translocate protein effectors...

    Authors: Colin A Cooper, David T Mulder, Sarah E Allison, Ana Victoria C Pilar and Brian K Coombes

    Citation: BMC Microbiology 2013 13:221

    Content type: Research article

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