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Microbe-host interactions and microbial pathogenicity

Section edited by David Nelson

This section aims to publish studies looking at all aspects of microbe-host interactions and pathogenicity including pathogenic mechanisms, virulence factors, host invasion, immune evasion, host defence, immunity, immunology and symbiotic interactions.

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  1. Nontypeable Haemophilus influenzae (NTHi) is one of the most common Gram-negative pathogens in otitis media and exacerbation of chronic obstructive pulmonary disease. NTHi has been reported to invade bronchial ep...

    Authors: Masaki Ikeda, Noriyuki Enomoto, Dai Hashimoto, Tomoyuki Fujisawa, Naoki Inui, Yutaro Nakamura, Takafumi Suda and Toshi Nagata

    Citation: BMC Microbiology 2015 15:263

    Content type: Research article

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  2. Burkholderia pseudomallei (Bp) and Burkholderia mallei (Bm) are Gram-negative facultative intracellular pathogens, which are the causative agents of melioidosis and glanders, respectiv...

    Authors: Chih-Yuan Chiang, Ricky L. Ulrich, Melanie P. Ulrich, Brett Eaton, Jenifer F. Ojeda, Douglas J. Lane, Krishna P. Kota, Tara A. Kenny, Jason T. Ladner, Samuel P. Dickson, Kathleen Kuehl, Rahul Raychaudhuri, Mei Sun, Sina Bavari, Mark J. Wolcott, David Covell…

    Citation: BMC Microbiology 2015 15:259

    Content type: Research article

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  3. 14-3-3 proteins comprise a family of eukaryotic multifunctional proteins involved in several cellular processes. The Pb14-3-3 of Paracoccidioides brasiliensis seems to play an important role in the Paracoccidioid...

    Authors: Patricia Akemi Assato, Julhiany de Fátima da Silva, Haroldo Cesar de Oliveira, Caroline Maria Marcos, Danuza Rossi, Sandro Roberto Valentini, Maria José Soares Mendes-Giannini, Cleslei Fernando Zanelli and Ana Marisa Fusco-Almeida

    Citation: BMC Microbiology 2015 15:256

    Content type: Research article

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  4. Seafood is not considered the natural habitat of Salmonella except the river fish, but still, the incidence of Salmonella in seafood is in a steady rise. By extending our understanding of Salmonella growth dynami...

    Authors: Rakesh Kumar, Tirtha K. Datta and Kuttanappilly V. Lalitha

    Citation: BMC Microbiology 2015 15:254

    Content type: Research article

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  5. Microbiological assays require accurate and reproducible preparation of bacterial inocula. Inocula prepared on different days by different individuals can vary significantly from experiment to experiment. This...

    Authors: Travis B. Nielsen, Kevin W. Bruhn, Paul Pantapalangkoor, Justin L. Junus and Brad Spellberg

    Citation: BMC Microbiology 2015 15:252

    Content type: Methodology article

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  6. Due to its extraordinary chemical properties, the cysteine amino acid residue is often involved in protein folding, electron driving, sensing stress, and binding metals such as iron or zinc. Lactococcus lactis, a...

    Authors: Célia Roussel, Bénédicte Cesselin, Rémy Cachon and Philippe Gaudu

    Citation: BMC Microbiology 2015 15:246

    Content type: Research article

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  7. Lipopolysaccharides (LPS) are complex, amphipathic biomolecules that constitute the major surface component of Gram-negative bacteria. Leptospira, unlike other human-pathogenic spirochetes, produce LPS, which is ...

    Authors: Kailash P. Patra, Biswa Choudhury, Michael M. Matthias, Sheyenne Baga, Keya Bandyopadhya and Joseph M. Vinetz

    Citation: BMC Microbiology 2015 15:244

    Content type: Research article

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  8. Mutant Allium sativum leaf agglutinin (mASAL) is a potent, biosafe, antifungal protein that exhibits fungicidal activity against different phytopathogenic fungi, including Rhizoctonia solani.

    Authors: Prithwi Ghosh, Amit Roy, Daniel Hess, Anupama Ghosh and Sampa Das

    Citation: BMC Microbiology 2015 15:237

    Content type: Research article

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  9. Chlamydia pneumoniae is a common human pathogen that is associated with upper and lower respiratory tract infections. It has also been suggested that C. pneumoniae infection can trigge...

    Authors: Xianbao He, Yanmei Liang, Michael P. LaValley, Juying Lai and Robin R. Ingalls

    Citation: BMC Microbiology 2015 15:228

    Content type: Research article

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  10. The pathogenic yeast Cryptococcus neoformans causes life-threatening meningoencephalitis in individuals suffering from HIV/AIDS. The cyclic-AMP/protein kinase A (PKA) signal transduction pathway regulates the pro...

    Authors: Jennifer M. H. Geddes, Daniel Croll, Mélissa Caza, Nikolay Stoynov, Leonard J. Foster and James W. Kronstad

    Citation: BMC Microbiology 2015 15:206

    Content type: Research article

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  11. Candida parapsilosis and C. tropicalis increasingly compete with C. albicans—the most common fungal pathogen in humans—as causative agents of severe candidiasis in immunocompromised pa...

    Authors: Andrzej Kozik, Justyna Karkowska-Kuleta, Dorota Zajac, Oliwia Bochenska, Sylwia Kedracka-Krok, Urszula Jankowska and Maria Rapala-Kozik

    Citation: BMC Microbiology 2015 15:197

    Content type: Research article

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  12. Koumiss is a traditionally fermented mare’s milk described with health-promoting potentials for decades. However, only a few studies focused on the probiotic strains isolated from koumiss. In this study, we co...

    Authors: Jingjing Rong, Houfeng Zheng, Ming Liu, Xu Hu, Tao Wang, Xingwei Zhang, Feng Jin and Li Wang

    Citation: BMC Microbiology 2015 15:196

    Content type: Research article

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  13. Phytoplasmas are bacterial plant pathogens (class Mollicutes), transmitted by phloem feeding leafhoppers, planthoppers and psyllids in a persistent/propagative manner. Transmission of phytoplasmas is under the...

    Authors: Mahnaz Rashidi, Luciana Galetto, Domenico Bosco, Andrea Bulgarelli, Marta Vallino, Flavio Veratti and Cristina Marzachì

    Citation: BMC Microbiology 2015 15:193

    Content type: Research article

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  14. Several experimental animal models have been used to study the pathogenesis of dengue disease; however, most of the studies used laboratory-adapted viruses, which lack the virulence of viruses circulating in h...

    Authors: Veridiana Ester Barros, Nilton Nascimento dos Santos-Junior, Alberto Anastacio Amarilla, Adriana Moreira Soares, Rafael Lourencini, Amanda Cristina Trabuco and Victor Hugo Aquino

    Citation: BMC Microbiology 2015 15:189

    Content type: Research article

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  15. The phytohormone indole-3-acetic acid (IAA) is widely distributed among plant-associated bacteria. Certain strains of the Pseudomonas syringae complex can further metabolize IAA into a less biologically active am...

    Authors: Melissa G. Castillo-Lizardo, Isabel M. Aragón, Vivian Carvajal, Isabel M. Matas, María Luisa Pérez-Bueno, María-Trinidad Gallegos, Matilde Barón and Cayo Ramos

    Citation: BMC Microbiology 2015 15:165

    Content type: Research article

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  16. Chlamydia spp. are believed to use a conserved virulence factor called type III secretion (T3S) to facilitate the delivery of effector proteins from the bacterial pathogen to the host cell. Important early effect...

    Authors: David C. Bulir, Daniel A. Waltho, Christopher B. Stone, Steven Liang, Christopher K. W. Chiang, Kenneth A. Mwawasi, Jordan C. Nelson, Steven W. Zhang, Samantha P. Mihalco, Zachariah C. Scinocca and James B. Mahony

    Citation: BMC Microbiology 2015 15:163

    Content type: Research article

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  17. The internalization of Aspergillus fumigatus into alveolar epithelial cells (AECs) is tightly controlled by host cellular actin dynamics, which require close modulation of the ADF (actin depolymerizing factor)/co...

    Authors: Zhiyao Bao, Xuelin Han, Fangyan Chen, Xiaodong Jia, Jingya Zhao, Changjian Zhang, Chen Yong, Shuguang Tian, Xin Zhou and Li Han

    Citation: BMC Microbiology 2015 15:161

    Content type: Research article

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  18. Francisella tularensis is a Gram-negative bacterium that infects hundreds of species including humans, and has evolved to grow efficiently within a plethora of cell types. RipA is a conserved membrane protein of...

    Authors: Cheryl N Miller, Shaun P Steele, Jason C Brunton, Ronald J Jenkins, Eric D LoVullo, Sharon A Taft-Benz, Artur Romanchuk, Corbin D Jones, Garry D Dotson, Edward J Collins and Thomas H Kawula

    Citation: BMC Microbiology 2014 14:336

    Content type: Research article

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  19. The very-preterm infant gut microbiota is increasingly explored due to its probable role in the development of life threatening diseases. Results of high-throughput studies validate and renew the interest in a...

    Authors: Fabien Aujoulat, Laurent Roudière, Jean-Charles Picaud, Aurélien Jacquot, Anne Filleron, Dorine Neveu, Thierry-Pascal Baum, Hélène Marchandin and Estelle Jumas-Bilak

    Citation: BMC Microbiology 2014 14:325

    Content type: Research article

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  20. Pathogenic chlamydiae are obligate intracellular pathogens and have adapted successfully to human cells, causing sexually transmitted diseases or pneumonia. Chlamydial outer protein N (CopN) is likely a critic...

    Authors: Kasumi Ishida, Junji Matsuo, Yoshimasa Yamamoto and Hiroyuki Yamaguchi

    Citation: BMC Microbiology 2014 14:330

    Content type: Research article

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  21. Klebsiella pneumoniae has emerged worldwide as a cause of pyogenic liver abscess (PLA) often complicated by meningitis and endophthalmitis. Early detection of this infectious disease will improve its clinical ou...

    Authors: Tzu-Lung Lin, Yi-Ping Chuang, Yu-Tsung Huang, Pei-Fang Hsieh, Yi-Tsung Lin and Jin-Town Wang

    Citation: BMC Microbiology 2014 14:321

    Content type: Research article

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  22. The social amoeba Dictyostelium discoideum interacts with bacteria in a variety of ways. It is a predator of bacteria, can be infected or harmed by bacteria, and can form symbiotic associations with bacteria. Som...

    Authors: Susanne DiSalvo, Debra A Brock, jeff smith, David C Queller and Joan E Strassmann

    Citation: BMC Microbiology 2014 14:328

    Content type: Research article

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  23. Attachment is essential to maintain bacteria at their preferential intestinal colonization sites. There is little information on the influence of different environmental conditions in the interaction of atypic...

    Authors: Fabiano T Romão, Rodrigo T Hernandes, Denise Yamamoto, Lika Osugui, Ana Flavia Popi and Tânia A T Gomes

    Citation: BMC Microbiology 2014 14:299

    Content type: Research article

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  24. Staphylococcus aureus (S. aureus) is a frequent cause of skin and soft tissue infections. A unique feature of S. aureus is the combined presence of coagulases that trigger fibrin formation and of the plasminogen...

    Authors: Marijke Peetermans, Thomas Vanassche, Laurens Liesenborghs, Jorien Claes, Greetje Vande Velde, Jakub Kwiecinksi, Tao Jin, Bart De Geest, Marc F Hoylaerts, Roger H Lijnen and Peter Verhamme

    Citation: BMC Microbiology 2014 14:310

    Content type: Research article

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  25. The composition of the gut microbiota has recently been associated with health and disease, particularly with obesity. Some studies suggested a higher proportion of Firmicutes and a lower proportion of Bactero...

    Authors: Juan S Escobar, Bernadette Klotz, Beatriz E Valdes and Gloria M Agudelo

    Citation: BMC Microbiology 2014 14:311

    Content type: Research article

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  26. The oomycete Phytophthora infestans possesses active RNA silencing pathways, which presumably enable this plant pathogen to control the large numbers of transposable elements present in its 240 Mb genome. Small R...

    Authors: Anna KM Åsman, Ramesh R Vetukuri, Sultana N Jahan, Johan Fogelqvist, Pádraic Corcoran, Anna O Avrova, Stephen C Whisson and Christina Dixelius

    Citation: BMC Microbiology 2014 14:308

    Content type: Research article

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  27. Pseudomonas syringae is pathogenic to a large number of plant species. For host colonization and disease progression, strains of this bacterium utilize an array of type III-secreted effectors and other virulence...

    Authors: Alexey Dudnik and Robert Dudler

    Citation: BMC Microbiology 2014 14:304

    Content type: Research article

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  28. Bacillus anthracis is the etiological agent of anthrax. Lethal toxin (LT) produced by B. anthracis is a well-known key virulence factor for anthrax because of its strong cytotoxic activity. However, little is kn...

    Authors: Jun Ho Jeon, Yeon Hee Kim, Min Kyung Choi, Kyung Ae Kim, Hae-Ri Lee, Jeyoun Jang, Yu-Ri Kim, Jeong-Hoon Chun, Seong Kug Eo, Tae Sung Kim and Gi-eun Rhie

    Citation: BMC Microbiology 2014 14:300

    Content type: Research article

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  29. Chlamydia trachomatis (C. trachomatis) is a clinically significant human pathogen and one of the leading causative agents of sexually transmitted diseases. As obligate intracellular bacteria, C. trachomatis has ...

    Authors: Achchhe L Patel, Xiaofei Chen, Scott T Wood, Elizabeth S Stuart, Kathleen F Arcaro, Doris P Molina, Snezana Petrovic, Cristina M Furdui and Allen W Tsang

    Citation: BMC Microbiology 2014 14:277

    Content type: Research article

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  30. We previously identified an ECF sigma factor, σS, that is important in the stress and virulence response of Staphylococcus aureus. Transcriptional profiling of sigS revealed that it is differentially expressed in...

    Authors: Whittney N Burda, Halie K Miller, Christina N Krute, Shane L Leighton, Ronan K Carroll and Lindsey N Shaw

    Citation: BMC Microbiology 2014 14:280

    Content type: Research article

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  31. Human immunodeficiency virus type 1 (HIV-1) Vif hijacks an E3 ligase to suppress natural APOBEC3 restriction factors, and core binding factor β (CBF-β) is required for this process. Although an extensive regio...

    Authors: Hong Wang, Guoyue Lv, Xiaohong Zhou, Zhaolong Li, Xin Liu, Xiao-Fang Yu and Wenyan Zhang

    Citation: BMC Microbiology 2014 14:290

    Content type: Research article

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  32. Pseudomonas fuscovaginae (Pfv) is an emerging plant pathogen of rice and also of other gramineae plants. It causes sheath brown rot disease in rice with symptoms that are characterized by brown lesions on the fl...

    Authors: Hitendra Kumar Patel, Maura Matiuzzo, Iris Bertani, Vincent de Paul Bigirimana, Gavin J Ash, Monica Höfte and Vittorio Venturi

    Citation: BMC Microbiology 2014 14:274

    Content type: Research article

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  33. Streptococcus suis is a major problem in the swine industry causing meningitis, arthritis and pericarditis in piglets. Pathogenesis of S. suis is poorly understood. We previously showed that introduction of a 3k...

    Authors: Astrid de Greeff, Herma Buys, Jerry M Wells and Hilde E Smith

    Citation: BMC Microbiology 2014 14:264

    Content type: Research article

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  34. Periodontal diseases are polymicrobial diseases that cause the inflammatory destruction of the tooth-supporting (periodontal) tissues. Their initiation is attributed to the formation of subgingival biofilms th...

    Authors: Kai Bao, Georgios N Belibasakis, Thomas Thurnheer, Joseph Aduse-Opoku, Michael A Curtis and Nagihan Bostanci

    Citation: BMC Microbiology 2014 14:258

    Content type: Research article

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  35. MicroRNAs (miRNAs) are known to regulate various biological processes, including expression of cellular gene and virus-induced inflammation. Recently, studies have indicated that some miRNAs could regulate inf...

    Authors: Eun-Ji Choi, Hyeun Bum Kim, Yun Hee Baek, Eun-Ha Kim, Philippe Noriel Q Pascua, Su-Jin Park, Hyeok-il Kwon, Gyo-Jin Lim, Semi Kim, Young-Il Kim and Young-Ki Choi

    Citation: BMC Microbiology 2014 14:252

    Content type: Research article

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  36. The heat sensitive factor (HSF) of the fish pathogen Yersinia ruckeri was previously identified as an unusual band on SDS-PAGE. According to this, Y. ruckeri strains were classified in HSF+ and HSF ...

    Authors: Roberto Navais, Jessica Méndez, Desirée Cascales, Pilar Reimundo and José A Guijarro

    Citation: BMC Microbiology 2014 14:221

    Content type: Research article

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  37. Fibronectin Binding Protein A (FnBPA) is an invasin from Staphylococcus aureus that allows this pathogen to internalize into eukaryote cells. It was previously demonstrated that recombinant Lactococcus lactis exp...

    Authors: Juliana F Almeida, Denis Mariat, Vasco Azevedo, Anderson Miyoshi, Alejandra de Moreno de LeBlanc, Silvina del Carmen, Rebeca Martin, Philippe Langella, Jean-Guy LeBlanc and Jean-Marc Chatel

    Citation: BMC Microbiology 2014 14:248

    Content type: Research article

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  38. Increasing evidence suggest that the gut microbiota plays an important role in liver pathology after acute alcohol intake. The aim of our study was to investigate the roles played by commensal bacteria in alco...

    Authors: Canesso MCC, Lacerda NL, Ferreira CM, Gonçalves JL, Almeida D, Gamba C, Cassali G, Pedroso SH, Moreira C, Martins FS, Nicoli JR, Teixeira MM, Godard ALB and Vieira AT

    Citation: BMC Microbiology 2014 14:240

    Content type: Research article

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  39. Tumor necrosis factor alpha (TNF-α) plays a central role in the initiation and maintenance of immune responses to periodontopathic bacteria. However, excess TNF-α leads to dysregulated immune responses and pro...

    Authors: Yoshiko Kato, Makoto Hagiwara, Yuichi Ishihara, Ryutaro Isoda, Shinsuke Sugiura, Toshinori Komatsu, Naoyuki Ishida, Toshihide Noguchi and Kenji Matsushita

    Citation: BMC Microbiology 2014 14:229

    Content type: Research article

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  40. Caseous lymphadenitis (CL) is a contagious infectious disease of small ruminants caused by Corynebacterium pseudotuberculosis. Is characterized by the formation of abscesses in the lymph nodes and intestines of i...

    Authors: Andréia Pacheco de Souza, Vera Lúcia Costa Vale, Marcos da Costa Silva, Inara Barbosa de Oliveira Araújo, Soraya Castro Trindade, Lília Ferreira de Moura-Costa, Gabriele Costa Rodrigues, Tatiane Santana Sales, Heidiane Alves dos Santos, Paulo Cirino de Carvalho-Filho, Milton Galdino de Oliveira-Neto, Robert Eduard Schaer and Roberto Meyer

    Citation: BMC Microbiology 2014 14:230

    Content type: Research article

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  41. Several intracellular bacterial pathogens have evolved subtle strategies to subvert vesicular trafficking pathways of their host cells to avoid killing and to replicate inside the cells. Brucellae are Gram-negati...

    Authors: Isabelle Hamer, Emeline Goffin, Xavier De Bolle, Jean-Jacques Letesson and Michel Jadot

    Citation: BMC Microbiology 2014 14:223

    Content type: Research article

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  42. Analysis of the Escherichia coli collection of reference strains (ECOR) for the presence of the gene locus clyA, which encodes the pore-forming protein ClyA (cytolysin A), revealed that a non-functional clyA locu...

    Authors: Constance Oben Ayuk Enow, Jan Oscarsson, Nikola Zlatkov, Marie Westermark, Marylise Duperthuy, Sun Nyunt Wai and Bernt Eric Uhlin

    Citation: BMC Microbiology 2014 14:216

    Content type: Research article

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  43. Chlamydia trachomatis is an intracellular bacteria which consist of three biovariants; trachoma (serovars A-C), urogenital (serovars D-K) and lymphogranuloma venereum (L1-L3), causing a wide spectrum of disease ...

    Authors: Baishakhi Datta, Florence Njau, Jessica Thalmann, Hermann Haller and Annette D Wagner

    Citation: BMC Microbiology 2014 14:209

    Content type: Research article

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  44. The ability of S. pneumoniae to generate infections depends on the restrictions imposed by the host’s immunity, in order to prevent the bacterium from spreading from the nasopharynx to other tissues, such as the ...

    Authors: Hugo Macedo-Ramos, Andre F Batista, Alvaro Carrier-Ruiz, Lucineia Alves, Silvana Allodi, Victor T Ribeiro-Resende, Lucia M Teixeira and Wagner Baetas-da-Cruz

    Citation: BMC Microbiology 2014 14:211

    Content type: Research article

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  45. Burkholderia pseudomallei is a facultative intracellular pathogen and the causative agent of melioidosis. A conserved type III secretion system (T3SS3) and type VI secretion system (T6SS1) are critical for intra...

    Authors: Yahua Chen, Imke Schröder, Christopher T French, Artur Jaroszewicz, Xiao Jie Yee, Boon-Eng Teh, Isabelle J Toesca, Jeff F Miller and Yunn-Hwen Gan

    Citation: BMC Microbiology 2014 14:206

    Content type: Research article

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