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Microbe-host interactions and microbial pathogenicity

Section edited by David Nelson

This section aims to publish studies looking at all aspects of microbe-host interactions and pathogenicity including pathogenic mechanisms, virulence factors, host invasion, immune evasion, host defence, immunity, immunology and symbiotic interactions.

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  1. Avian beta-defensins (AvBD) are small, cationic, antimicrobial peptides. The potential application of AvBDs as alternatives to antibiotics has been the subject of interest. However, the mechanisms of action re...

    Authors: Ming Yang, Chunye Zhang, Xuehan Zhang, Michael Z. Zhang, George E. Rottinghaus and Shuping Zhang

    Citation: BMC Microbiology 2016 16:210

    Content type: Research article

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  2. There is a rapid emergence of multiple resistant gram-negative bacteria due to overuse of antibiotics in the treatment of infections. Biofilms consist of polymicrobial communities that survive the host’s defen...

    Authors: Chongcong Wu, Sravya Nakka, Sepahdar Mansouri, Torbjörn Bengtsson, Tayeb Nayeri and Fariba Nayeri

    Citation: BMC Microbiology 2016 16:209

    Content type: Research article

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  3. As an agriculturally important oomycete genus, Phytophthora contains a large number of destructive plant pathogens that severely threaten agricultural production and natural ecosystems. Among them is the broad ho...

    Authors: Dongliang Wu, Natasha Navet, Yingchao Liu, Janice Uchida and Miaoying Tian

    Citation: BMC Microbiology 2016 16:204

    Content type: Methodology article

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  4. Highly virulent strains of the gastric pathogen Helicobacter pylori encode a type IV secretion system (T4SS) that delivers the effector protein CagA into gastric epithelial cells. Translocated CagA undergoes tyro...

    Authors: Judith Lind, Steffen Backert, Rebecca Hoffmann, Jutta Eichler, Yoshio Yamaoka, Guillermo I. Perez-Perez, Javier Torres, Heinrich Sticht and Nicole Tegtmeyer

    Citation: BMC Microbiology 2016 16:201

    Content type: Research article

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  5. Burkholderia cenocepacia is a Gram-negative, opportunistic pathogen that is a cause of morbidity and mortality in patients with cystic fibrosis (CF). Research efforts over the past few...

    Authors: Christiaan D. M. Wijers, Ryan Vagedes and Christine Weingart

    Citation: BMC Microbiology 2016 16:200

    Content type: Methodology article

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  6. Pseudomonas syringae infects diverse plant species and is widely used in the study of effector function and the molecular basis of disease. Although the relationship between bacterial ...

    Authors: Bronwyn G. Butcher, Suma Chakravarthy, Katherine D’Amico, Kari Brossard Stoos and Melanie J. Filiatrault

    Citation: BMC Microbiology 2016 16:194

    Content type: Research article

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  7. Largemouth bronze gudgeon (Coreius guichenoti) is of economic importance in China, distributed in upstream regions of the Yangtze River in China. But it has recently dramatically declined and is close to eliminat...

    Authors: Xuemei Li, Qingyun Yan, Einar Ringø, Xingbing Wu, Yongfeng He and Deguo Yang

    Citation: BMC Microbiology 2016 16:191

    Content type: Research article

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  8. Our group has developed a new process for isolating and identifying novel cationic antimicrobial peptides from small amounts of biological samples. Previously, we identified several active antimicrobial peptid...

    Authors: Stephanie M. Barksdale, Evelyn J. Hrifko, Ezra Myung-Chul Chung and Monique. L. van Hoek

    Citation: BMC Microbiology 2016 16:189

    Content type: Research article

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  9. The complications in healthcare systems associated with antibiotic-resistant microorganisms have resulted in an intense search for new effective antimicrobials. Attractive substances from which novel antibioti...

    Authors: Hazem Khalaf, Sravya Sowdamini Nakka, Camilla Sandén, Anna Svärd, Kjell Hultenby, Nikolai Scherbak, Daniel Aili and Torbjörn Bengtsson

    Citation: BMC Microbiology 2016 16:188

    Content type: Research article

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  10. Necrotic enteritis (NE) caused by netB-positive type A Clostridium perfringens is an important bacterial disease of poultry. Through its complex regulatory system, C. perfringens orchestrates the expression of a ...

    Authors: Valeria R. Parreira, Kay Russell, Spiridoula Athanasiadou and John F. Prescott

    Citation: BMC Microbiology 2016 16:186

    Content type: Research article

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  11. Rapid identification and antimicrobial susceptibility testing (AST) of the causative agent(s) of bloodstream infections can lead to prompt appropriate antimicrobial therapy. To shorten species identification, ...

    Authors: Simona Barnini, Veronica Brucculeri, Paola Morici, Emilia Ghelardi, Walter Florio and Antonella Lupetti

    Citation: BMC Microbiology 2016 16:185

    Content type: Methodology article

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  12. The Bacillus anthracis S-layer protein, BslA, plays a crucial role in mammalian infection. BslA is required to mediate adherence between host cells and vegetative forms of bacteria and this interaction promotes t...

    Authors: Yanchun Wang, Ying Wei, Shengling Yuan, Haoxia Tao, Jie Dong, Zhaoshan Zhang, Wei Tian and Chunjie Liu

    Citation: BMC Microbiology 2016 16:183

    Content type: Research article

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  13. The lp28-1 plasmid is required for persistent infection by the Lyme disease spirochete, Borrelia burgdorferi. Mutational studies on this plasmid have shown that the vls locus is important for antigenic variation ...

    Authors: Petronella R. Hove Magunda and Troy Bankhead

    Citation: BMC Microbiology 2016 16:180

    Content type: Research article

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  14. The ability of Yersinia pestis to form a biofilm is an important characteristic in flea transmission of this pathogen. Y. pestis laterally acquired two plasmids (pPCP1and pMT1) and the ability to form biofilms wh...

    Authors: Zizhong Liu, Xiaofang Gao, Hongduo Wang, Haihong Fang, Yanfeng Yan, Lei Liu, Rong Chen, Dongsheng Zhou, Ruifu Yang and Yanping Han

    Citation: BMC Microbiology 2016 16:176

    Content type: Research article

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  15. Streptococcus agalactiae (GBS) is a common pathogen to infect newborn, woman, the elderly, and immuno-compromised human and fish. 37 fish isolates and 554 human isolates of the GBS in ...

    Authors: Chishih Chu, Pei-Yu Huang, Hung-Ming Chen, Ying-Hsiang Wang, I-An Tsai, Chih-Cheng Lu and Che-Chun Chen

    Citation: BMC Microbiology 2016 16:175

    Content type: Research article

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  16. The opportunistic bacterial pathogen Legionella pneumophila uses substrate effectors of Dot/Icm type IVB secretion system (T4BSS) to accomplish survival and replication in amoebae cells and mammalian alveolar mac...

    Authors: Bei-bei Zhao, Xiang-hui Li, Yong-lun Zeng and Yong-jun Lu

    Citation: BMC Microbiology 2016 16:174

    Content type: Research article

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  17. Study of a clinic case reveals that alpha-1-antitrypsin (AAT) deficiency is related to CD4+ T cell count decline and AIDS progression, suggesting that AAT might be an endogenous inhibitor of HIV/AIDS. Previous...

    Authors: Xueyuan Zhou, Zhu Liu, Jun Zhang, Joseph W. Adelsberger, Jun Yang and Gregory F. Burton

    Citation: BMC Microbiology 2016 16:172

    Content type: Research article

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  18. Regardless of sanitation practices implemented to reduce Salmonella prevalence in poultry processing plants, the problem continues to be an issue. To gain an understanding of the attachment mechanism of Salmonell...

    Authors: Sanaz Salehi, Kevin Howe, John Brooks, Mark L. Lawrence, R. Hartford Bailey and Attila Karsi

    Citation: BMC Microbiology 2016 16:168

    Content type: Research article

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  19. Pet is a toxin from the family of Serine Protease Autotransporters of Enterobacteriaceae which was initially identified in Enteroaggregative Escherichia coli strains. This protease exhibits enterotoxin properties...

    Authors: L. M. Rocha-Ramírez, U. Hernández-Chiñas, D. Baños-Rojas, J. Xicohtencatl-Cortés, M. E. Chávez-Berrocal, G. Rico-Rosillo, R. Kretschmer and C. A. Eslava

    Citation: BMC Microbiology 2016 16:158

    Content type: Research article

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  20. Streptococcus pneumoniae causes several human diseases, including pneumonia and meningitis, in which pathology is associated with an excessive inflammatory response. A major inducer of...

    Authors: Denja Baumgartner, Suzanne Aebi, Denis Grandgirard, Stephen L. Leib, Annette Draeger, Eduard Babiychuk and Lucy J. Hathaway

    Citation: BMC Microbiology 2016 16:154

    Content type: Research article

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  21. Leptospira interrogans is a spirochaete responsible for leptospirosis in mammals. The molecular mechanisms of the Leptospira virulence remain mostly unknown. Recently, it has been demo...

    Authors: Joanna Krajewska, Zbigniew Arent, Daniel Więckowski, Michal Zolkiewski and Sabina Kędzierska-Mieszkowska

    Citation: BMC Microbiology 2016 16:151

    Content type: Research article

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  22. Plant cell wall degrading enzymes (PCWDEs) are a subset of carbohydrate-active enzymes (CAZy) produced by plant pathogens to degrade plant cell walls. To counteract PCWDEs, plants release PCWDEs inhibitor prot...

    Authors: Hao-Xun Chang, Craig R. Yendrek, Gustavo Caetano-Anolles and Glen L. Hartman

    Citation: BMC Microbiology 2016 16:147

    Content type: Research article

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    The Erratum to this article has been published in BMC Microbiology 2017 17:110

  23. Similar to Gram-negative organisms, Borrelia spirochetes are dual-membrane organisms with both an inner and outer membrane. Although the outer membrane contains integral membrane proteins, few of the borrelial ou...

    Authors: Melisha R. Kenedy, Edgar J. Scott II, Binu Shrestha, Arvind Anand, Henna Iqbal, Justin D. Radolf, David W. Dyer and Darrin R. Akins

    Citation: BMC Microbiology 2016 16:141

    Content type: Research article

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  24. The exopolysaccharide xanthan is a natural product which is extensively used in industry. It is a thickening agent in many fields, from oil recovery to the food sector. Xanthan is produced by the Gram negative...

    Authors: Tim Steffens, Frank-Jörg Vorhölter, Marco Giampà, Gerd Hublik, Alfred Pühler and Karsten Niehaus

    Citation: BMC Microbiology 2016 16:93

    Content type: Research article

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  25. Many Gram-negative bacterial pathogens mediate host-microbe interactions via utilization of the type III secretion (T3S) system. The T3S system is a complex molecular machine consisting of more than 20 protein...

    Authors: R. Ryan McNally, Quan Zeng and George W. Sundin

    Citation: BMC Microbiology 2016 16:88

    Content type: Research article

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  26. Fusobacterium nucleatum, a well studied bacterium in periodontal diseases, appendicitis, gingivitis, osteomyelitis and pregnancy complications has recently gained attention due to its ...

    Authors: Amit Kumar, Pragna Lakshmi Thotakura, Basant Kumar Tiwary and Ramadas Krishna

    Citation: BMC Microbiology 2016 16:84

    Content type: Research article

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  27. Staphylococcus aureus gene expression has been sparsely studied in deep-sited infections in humans. Here, we characterized the staphylococcal transcriptome in vivo and the joint fluid ...

    Authors: Yijuan Xu, Raluca Georgiana Maltesen, Lone Heimann Larsen, Henrik Carl Schønheyder, Vang Quy Le, Jeppe Lund Nielsen, Per Halkjær Nielsen, Trine Rolighed Thomsen and Kåre Lehmann Nielsen

    Citation: BMC Microbiology 2016 16:80

    Content type: Research article

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  28. Enteric methane from rumen methanogens is responsible for 25.9 % of total methane emissions in the United States. Rumen methanogens also contribute to decreased animal feed efficiency. For methane mitigation s...

    Authors: Laura M. Cersosimo, Melissa L. Bainbridge, Jana Kraft and André-Denis G. Wright

    Citation: BMC Microbiology 2016 16:78

    Content type: Research article

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  29. Free-living amoebae (FLA) and particularly acanthamoebae serve as vehicles and hosts for Legionella pneumophila, among other pathogenic microorganisms. Within the amoebae, L. pneumophila activates a complex regul...

    Authors: Elisabeth Dietersdorfer, Sílvia Cervero-Aragó, Regina Sommer, Alexander K. Kirschner and Julia Walochnik

    Citation: BMC Microbiology 2016 16:74

    Content type: Research article

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  30. Avian pathogenic Escherichia coli strains cause extraintestinal diseases in birds, leading to substantial economic losses to the poultry industry worldwide. Bacteria that invade cells can overcome the host humora...

    Authors: Livia Pilatti, Jacqueline Boldrin de Paiva, Thaís Cabrera Galvão Rojas, Janaína Luisa Leite, Rogério Arcuri Conceição, Gerson Nakazato and Wanderley Dias da Silveira

    Citation: BMC Microbiology 2016 16:35

    Content type: Research article

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  31. Lyme borrelia genotypes differ in their capacity to cause disseminated disease. Gene array analysis was employed to profile the host transcriptome induced by Borrelia burgdorferi strains with different capacities...

    Authors: Mary M. Petzke, Radha Iyer, Andrea C. Love, Zoe Spieler, Andrew Brooks and Ira Schwartz

    Citation: BMC Microbiology 2016 16:29

    Content type: Research article

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  32. Classical strains of Salmonella enterica serovar Typhimurium (Typhimurium) predominantly cause a self-limiting diarrheal illness in humans and a systemic disease in mice. In this study, we report the characteriza...

    Authors: Magdalena Wiesner, Juan J. Calva, Víctor H. Bustamante, Deyanira Pérez-Morales, Marcos Fernández-Mora, Edmundo Calva and Claudia Silva

    Citation: BMC Microbiology 2016 16:18

    Content type: Research article

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  33. The genus Lactobacillus belongs to a large heterogeneous group of low G + C Gram-positive anaerobic bacteria, which are frequently used as probiotics. The health-beneficial effects, in particular the immunomodula...

    Authors: Sabina Górska, Barbara Buda, Ewa Brzozowska, Martin Schwarzer, Dagmar Srutkova, Hana Kozakova and Andrzej Gamian

    Citation: BMC Microbiology 2016 16:17

    Content type: Research article

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  34. The constitutive inflammation that characterizes advanced age is termed inflamm-aging. This process is associated with age-related changes to immune homeostasis and gut microbiota. We investigated the relation...

    Authors: Kyung-Ah Kim, Jin-Ju Jeong, Sul-Young Yoo and Dong-Hyun Kim

    Citation: BMC Microbiology 2016 16:9

    Content type: Research article

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  35. Endophytes are microbes that inhabit internal plant tissues without causing disease. Plant microbial communities consist of large numbers of endophyte species. Understanding the functions of these endophytes i...

    Authors: Hanan R. Shehata, Eric M. Lyons, Katerina S. Jordan and Manish N. Raizada

    Citation: BMC Microbiology 2016 16:8

    Content type: Research article

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  36. Gut bacteria-host interactions have been implicated in the pathogenesis of numerous human diseases, but few mechanisms have been described. The genetically tractable nematode worm Caenorhabditis elegans can be in...

    Authors: Shuzhen Sim and Martin L. Hibberd

    Citation: BMC Microbiology 2016 16:6

    Content type: Research article

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  37. In this study, we have evaluated the immunological status of hepatitis C virus (HCV)-infected patients aiming at identifying putative biomarkers associated with distinct degrees of liver fibrosis. Peripheral b...

    Authors: Soriane de Souza-Cruz, Marilú Barbieri Victória, Andréa Monteiro Tarragô, Allyson Guimarães da Costa, João Paulo Diniz Pimentel, Ericka Florêncio Pires, Lorene de Paula Araújo, Jordana Grazziela Coelho-dos-Reis, Matheus de Souza Gomes, Laurence Rodrigues Amaral, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Flamir da Silva Victória and Adriana Malheiro

    Citation: BMC Microbiology 2016 16:3

    Content type: Research article

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  38. The probiotic bacterium Phaeobacter inhibens strain S4Sm, isolated from the inner shell surface of a healthy oyster, secretes the antibiotic tropodithietic acid (TDA), is an excellent biofilm former, and increase...

    Authors: Wenjing Zhao, Christine Dao, Murni Karim, Marta Gomez-Chiarri, David Rowley and David R. Nelson

    Citation: BMC Microbiology 2016 16:1

    Content type: Research article

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  39. The symptoms of Clostridium difficile infection are mediated primarily by two toxins, TcdA and TcdB, the expression of which is governed by a multitude of factors including nutrient availability, growth phase and...

    Authors: Stephanie E. Willing, Emma J. Richards, Lluis Sempere, Aaron G. Dale, Simon M. Cutting and Neil F. Fairweather

    Citation: BMC Microbiology 2015 15:280

    Content type: Research article

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  40. Enteropathogenic Escherichia coli (EPEC) is distinguished mainly by the presence of EPEC adherence factor plasmid (pEAF) in typical EPEC (tEPEC) and its absence in atypical EPEC (aEPEC). The initial adherence to ...

    Authors: Claudia T. P. Moraes, Juliana M. Polatto, Sarita S. Rossato, Mariana Izquierdo, Danielle D. Munhoz, Fernando H. Martins, Daniel C. Pimenta, Mauricio J. Farfan, Waldir P. Elias, Ângela S. Barbosa and Roxane M. F. Piazza

    Citation: BMC Microbiology 2015 15:278

    Content type: Research article

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  41. The vaginal microbiota can impact the susceptibility of women to bacterial vaginosis (BV) and sexually transmitted infections (STIs). BV is characterized by depletion of Lactobacillus spp., an overgrowth of anaer...

    Authors: Laura M. Breshears, Vonetta L. Edwards, Jacques Ravel and Marnie L. Peterson

    Citation: BMC Microbiology 2015 15:276

    Content type: Research article

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  42. Small-molecule compounds that inhibit human immunodeficiency virus type 1 (HIV-1) infection can be used not only as drug candidates, but also as reagents to dissect the life cycle of the virus. Thus, it is des...

    Authors: Ru Bai, Xing-Jie Zhang, Yan-Li Li, Jing-Ping Liu, Hong-Bin Zhang, Wei-Lie Xiao, Jian-Xin Pu, Han-Dong Sun, Yong-Tang Zheng and Li-Xin Liu

    Citation: BMC Microbiology 2015 15:274

    Content type: Research article

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  43. Nontypeable Haemophilus influenzae (NTHi) is one of the most common Gram-negative pathogens in otitis media and exacerbation of chronic obstructive pulmonary disease. NTHi has been reported to invade bronchial ep...

    Authors: Masaki Ikeda, Noriyuki Enomoto, Dai Hashimoto, Tomoyuki Fujisawa, Naoki Inui, Yutaro Nakamura, Takafumi Suda and Toshi Nagata

    Citation: BMC Microbiology 2015 15:263

    Content type: Research article

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  44. Burkholderia pseudomallei (Bp) and Burkholderia mallei (Bm) are Gram-negative facultative intracellular pathogens, which are the causative agents of melioidosis and glanders, respectiv...

    Authors: Chih-Yuan Chiang, Ricky L. Ulrich, Melanie P. Ulrich, Brett Eaton, Jenifer F. Ojeda, Douglas J. Lane, Krishna P. Kota, Tara A. Kenny, Jason T. Ladner, Samuel P. Dickson, Kathleen Kuehl, Rahul Raychaudhuri, Mei Sun, Sina Bavari, Mark J. Wolcott, David Covell…

    Citation: BMC Microbiology 2015 15:259

    Content type: Research article

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  45. 14-3-3 proteins comprise a family of eukaryotic multifunctional proteins involved in several cellular processes. The Pb14-3-3 of Paracoccidioides brasiliensis seems to play an important role in the Paracoccidioid...

    Authors: Patricia Akemi Assato, Julhiany de Fátima da Silva, Haroldo Cesar de Oliveira, Caroline Maria Marcos, Danuza Rossi, Sandro Roberto Valentini, Maria José Soares Mendes-Giannini, Cleslei Fernando Zanelli and Ana Marisa Fusco-Almeida

    Citation: BMC Microbiology 2015 15:256

    Content type: Research article

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  46. Seafood is not considered the natural habitat of Salmonella except the river fish, but still, the incidence of Salmonella in seafood is in a steady rise. By extending our understanding of Salmonella growth dynami...

    Authors: Rakesh Kumar, Tirtha K. Datta and Kuttanappilly V. Lalitha

    Citation: BMC Microbiology 2015 15:254

    Content type: Research article

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