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Microbe-host interactions and microbial pathogenicity

Section edited by David Nelson

This section aims to publish studies looking at all aspects of microbe-host interactions and pathogenicity including pathogenic mechanisms, virulence factors, host invasion, immune evasion, host defence, immunity, immunology and symbiotic interactions.

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  1. Leptospira interrogans is a pathogenic, spirochetal bacterium that is responsible for leptospirosis, an emerging worldwide zoonosis. Leptospires colonize the renal proximal tubules and chronically infect the kidn...

    Authors: Takayoshi Yamaguchi, Naomi Higa, Nobuhiko Okura, Arina Matsumoto, Idam Hermawan, Tetsu Yamashiro, Toshihiko Suzuki and Claudia Toma

    Citation: BMC Microbiology 2018 18:64

    Content type: Research article

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  2. Galleria mellonella larvae were infected with conidia of Aspergillus fumigatus and the cellular and humoral immune responses of larvae to the pathogen were characterized as invasive aspergillosis developed.

    Authors: Gerard Sheehan, Gráinne Clarke and Kevin Kavanagh

    Citation: BMC Microbiology 2018 18:63

    Content type: Research article

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  3. The development of vaccines and evaluation of novel treatment strategies for invasive group A streptococcal (iGAS) disease requires suitable models of human infection that can be monitored longitudinally and a...

    Authors: L. E. Lamb, X. Zhi, F. Alam, M. Pyzio, C. L. Scudamore, S. Wiles and S. Sriskandan

    Citation: BMC Microbiology 2018 18:60

    Content type: Methodology article

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  4. Airway epithelium is the primary target for pathogens. It functions not only as a mechanical barrier, but also as an important sentinel of the innate immune system. However, the interactions and processes betw...

    Authors: Yinghua Li, Guangnan Liu, Jianquan Zhang, Xiaoning Zhong and Zhiyi He

    Citation: BMC Microbiology 2018 18:58

    Content type: Research article

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  5. Avian β-defensins (AvBD) are cationic antimicrobial peptides (CAMP) with broad-spectrum antimicrobial activity, chemotactic property, and low host cytotoxicity. However, their bactericidal activity is greatly ...

    Authors: Ming Yang, Chunye Zhang, Michael Z. Zhang and Shuping Zhang

    Citation: BMC Microbiology 2018 18:54

    Content type: Research article

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  6. Recent research has provided fascinating indications and evidence that the host health is linked to its microbial inhabitants. Due to the development of high-throughput sequencing technologies, more and more d...

    Authors: Yorick Janssens, Joachim Nielandt, Antoon Bronselaer, Nathan Debunne, Frederick Verbeke, Evelien Wynendaele, Filip Van Immerseel, Yves-Paul Vandewynckel, Guy De Tré and Bart De Spiegeleer

    Citation: BMC Microbiology 2018 18:50

    Content type: Database

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  7. Mice are a natural host for Rodentibacter (R.) pneumotropicus. Despite specific monitoring, it is still one of the most important infectious agents in laboratory animals. The objective of this study was to determ...

    Authors: Juliane Fornefett, Jaqueline Krause, Kristin Klose, Felix Fingas, Rayk Hassert, Laurentiu Benga, Thomas Grunwald, Uwe Müller, Wieland Schrödl and Christoph Georg Baums

    Citation: BMC Microbiology 2018 18:45

    Content type: Research article

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  8. Brucella causes a chronic and debilitating infection that leads to great economic losses and a public health burden. In this study, we demonstrated the brucellacidal effect of heat shock mediated by the induction...

    Authors: Huynh Tan Hop, Lauren Togonon Arayan, Alisha Wehdnesday Bernardo Reyes, Tran Xuan Ngoc Huy, Won Gi Min, Hu Jang Lee, Man Hee Rhee, Hong Hee Chang and Suk Kim

    Citation: BMC Microbiology 2018 18:44

    Content type: Research article

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  9. Global warming has triggered an increase in the prevalence and severity of coral disease, yet little is known about coral/pathogen interactions in the early stages of infection. The point of entry of the patho...

    Authors: E. Gibbin, A. Gavish, I. Domart-Coulon, E. Kramarsky-Winter, O. Shapiro, A. Meibom and A. Vardi

    Citation: BMC Microbiology 2018 18:39

    Content type: Methodology Article

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  10. Porcine tonsils are lympho-epithelial tissues, colonized by numerous bacteria and viruses, that act as a reservoir for both host-specific pathogens and zoonotic pathogens with a high potential of transmission ...

    Authors: Luis Carlos Pena Cortes, Rhiannon M. LeVeque, Julie Funk, Terence L. Marsh and Martha H. Mulks

    Citation: BMC Microbiology 2018 18:35

    Content type: Research article

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  11. Staphylococcus aureus cell wall anchored Serine Aspartate repeat containing protein D (SdrD) is a member of the microbial surface component recognising adhesive matrix molecules (MSCRAMMs). It is involved in the ...

    Authors: Clement Ajayi, Espen Åberg, Fatemeh Askarian, Johanna U. E. Sollid, Mona Johannessen and Anne-Merethe Hanssen

    Citation: BMC Microbiology 2018 18:34

    Content type: Research

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  12. We and others have previously shown that alterations in the mammalian gut microbiome are associated with diet, notably early life exposure to a maternal high fat diet (HFD). Here, we aimed to further these stu...

    Authors: Ryan M. Pace, Amanda L. Prince, Jun Ma, Benjamin D. W. Belfort, Alexia S. Harvey, Min Hu, Karalee Baquero, Peter Blundell, Diana Takahashi, Tyler Dean, Paul Kievit, Elinor L. Sullivan, Jacob E. Friedman, Kevin Grove and Kjersti M. Aagaard

    Citation: BMC Microbiology 2018 18:28

    Content type: Research article

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  13. Porphyromonas gingivalis (P. gingivalis), one of the main pathogenic bacteria involved in periodontitis, induces the expression of intercellular adhesion molecule − 1 (ICAM-1) and monocyte-endothelial cell adhesi...

    Authors: Wanyue Xu, Yaping Pan, Qiufang Xu, Yun Wu, Jiayu Pan, Jingya Hou, Li Lin, Xiaolin Tang, Chen Li, Jingbo Liu and Dongmei Zhang

    Citation: BMC Microbiology 2018 18:16

    Content type: Research article

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  14. The intracellular bacterial pathogen Legionella pneumophila proliferates in human alveolar macrophages, resulting in a severe pneumonia termed Legionnaires’ disease. Throughout the course of infection, L. pneumop...

    Authors: Xiaobo Yu, Rebecca R. Noll, Barbara P. Romero Dueñas, Samual C. Allgood, Kristi Barker, Jeffrey L. Caplan, Matthias P. Machner, Joshua LaBaer, Ji Qiu and M. Ramona Neunuebel

    Citation: BMC Microbiology 2018 18:5

    Content type: Research article

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  15. Ustilago esculenta, a pathogenic basidiomycete fungus, infects Zizania latifolia to form edible galls named Jiaobai in China. The distinct growth conditions of U. esculenta induced Z. ...

    Authors: Yafen Zhang, Qianchao Cao, Peng Hu, Haifeng Cui, Xiaoping Yu and Zihong Ye

    Citation: BMC Microbiology 2017 17:228

    Content type: Research article

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  16. Helicobacter pylori (H. pylori) is a Gram-negative, microaerophilic bacterium that is recognized as a major cause of chronic gastritis, peptic ulcers, and gastric cancer. Comparable to...

    Authors: Kristy Leker, Ivonne Lozano-Pope, Keya Bandyopadhyay, Biswa P. Choudhury and Marygorret Obonyo

    Citation: BMC Microbiology 2017 17:226

    Content type: Research article

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  17. Although plants produce many secondary metabolites, currently none of these are commercial antibiotics. Insects feeding on specific plants can harbour bacterial strains resistant to known antibiotics suggestin...

    Authors: Katarzyna Ignasiak and Anthony Maxwell

    Citation: BMC Microbiology 2017 17:223

    Content type: Research article

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  18. Vibrio anguillarum is an extracellular bacterial pathogen that is a causative agent of vibriosis in finfish and crustaceans with mortality rates ranging from 30% to 100%. Mutations in ...

    Authors: Xiangyu Mou, Edward J. Spinard, Shelby L. Hillman and David R. Nelson

    Citation: BMC Microbiology 2017 17:217

    Content type: Research article

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  19. During infection, inflammation is partially driven by the release of mediators which facilitate intercellular communication. Amongst these mediators are small membrane vesicles (MVs) that can be released by bo...

    Authors: Charlotte Volgers, Birke J. Benedikter, Gert E. Grauls, Paul H. M. Savelkoul and Frank R. M. Stassen

    Citation: BMC Microbiology 2017 17:216

    Content type: Research article

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  20. Streptococcus gallolyticus subsp. gallolyticus (S. gallolyticus) is the causative pathogen in up to 20% of streptococcal-induced infective endocarditis (IE) cases. However, the underly...

    Authors: Imke Grimm, Melanie Weinstock, Ingvild Birschmann, Jens Dreier, Cornelius Knabbe and Tanja Vollmer

    Citation: BMC Microbiology 2017 17:210

    Content type: Research article

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  21. Rice (Oryza sativa L. ssp. indica) seeds as plant microbiome present both an opportunity and a challenge to colonizing bacterial community living in close association with plants. Nevertheless, the roles and acti...

    Authors: Denver I. Walitang, Kiyoon Kim, Munusamy Madhaiyan, Young Kee Kim, Yeongyeong Kang and Tongmin Sa

    Citation: BMC Microbiology 2017 17:209

    Content type: Research article

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  22. Breast milk is a rich nutrient with a temporally dynamic nature. In particular, numerous alterations in the nutritional, immunological and microbiological content occur during the transition from colostrum to ...

    Authors: Marco Toscano, Roberta De Grandi, Diego Giampietro Peroni, Enzo Grossi, Valentina Facchin, Pasquale Comberiati and Lorenzo Drago

    Citation: BMC Microbiology 2017 17:205

    Content type: Research article

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  23. Outbreaks of infections caused by rapidly growing mycobacteria have been reported worldwide generally associated with medical procedures. Mycobacterium abscessus subsp. massiliense CRM0019 was obtained during an ...

    Authors: Giovanni Monteiro Ribeiro, Cristianne Kayoko Matsumoto, Fernando Real, Daniela Teixeira, Rafael Silva Duarte, Renato Arruda Mortara, Sylvia Cardoso Leão and Cristiane de Souza Carvalho-Wodarz

    Citation: BMC Microbiology 2017 17:195

    Content type: Research article

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  24. The complexity of the pathogenic mechanism underlying the host immune response to Actinobacillus pleuropneumonia (App) makes the use of preventive measures difficult, and a more global view of the host-pathogen i...

    Authors: Ping Li, Zhiwen Xu, Xiangang Sun, Yue Yin, Yi Fan, Jun Zhao, Xiyu Mao, Jianbo Huang, Fan Yang and Ling Zhu

    Citation: BMC Microbiology 2017 17:193

    Content type: Research article

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  25. Non-structural protein 1 (NS1) is a multifunctional protein and a crucial regulatory factor in the replication and pathogenesis of avian influenza virus (AIV). Studies have shown that NS1 can interact with a v...

    Authors: Yong Ma, Jiashan Sun, Linlin Gu, Hongmei Bao, Yuhui Zhao, Lin Shi, Wei Yao, Guobin Tian, Xiurong Wang and Hualan Chen

    Citation: BMC Microbiology 2017 17:191

    Content type: Research article

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  26. The bronchial epithelium serves as the first defendant line of host against respiratory inhaled pathogens, mainly through releasing chemokines (e.g. interleukin-8 (IL-8), interferon-induced protein 10 (IP-10) ...

    Authors: Jiaqiong Zou, Long Zhou, Chunlan Hu, Peng Jing, Xiaolan Guo, Sulan Liu, Yan Lei, Shangyu Yang, Jiankang Deng and Hong Zhang

    Citation: BMC Microbiology 2017 17:187

    Content type: Research article

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  27. Intracellular bacterium, Mycobacterium tuberculosis (M. tb), infects specifically macrophages as host cells. IRAK-M, a member of IRAK family, is a negative regulator in TLR signaling and specifically expresses in...

    Authors: Pei Shen, Quan Li, Jilei Ma, Maopeng Tian, Fei Hong, Xinjie Zhai, Jianrong Li, Hanju Huang and Chunwei Shi

    Citation: BMC Microbiology 2017 17:185

    Content type: Research article

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  28. Penicillium marneffei (P. marneffei) is a thermally dimorphic fungus pathogen that causes fatal infection. Alveolar macrophages are innate immune cells that have critical roles in prot...

    Authors: Xiaoying Dai, Congzheng Mao, Xiuwan Lan, Huan Chen, Meihua Li, Jing Bai, Jingmin Deng, Qiuli Liang, Jianquan Zhang, Xiaoning Zhong, Yi Liang, Jiangtao Fan, Honglin Luo and Zhiyi He

    Citation: BMC Microbiology 2017 17:177

    Content type: Research article

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  29. Probiotics are increasingly applied to prevent and treat a range of infectious, immune related and gastrointestinal diseases. Despite this, the mechanisms behind the putative effects of probiotics are poorly u...

    Authors: Martin Frederik Laursen, Rikke Pilmann Laursen, Anni Larnkjær, Kim F. Michaelsen, Martin Iain Bahl and Tine Rask Licht

    Citation: BMC Microbiology 2017 17:175

    Content type: Research article

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  30. Bacterial blight of rice caused by Xanthomonas oryzae pv. oryzae (Xoo) is one of the most important crop diseases in the world. More insights into the mechanistic regulation of bacterial pathogenesis will help us...

    Authors: Chao Yu, Huamin Chen, Fang Tian, Fenghuan Yang and Chenyang He

    Citation: BMC Microbiology 2017 17:171

    Content type: Research article

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  31. The World Health Organization has categorized plague as a re-emerging disease and the potential for Yersinia pestis to also be used as a bioweapon makes the identification of new drug targets against this pathoge...

    Authors: Nicola J. Senior, Kalesh Sasidharan, Richard J. Saint, Andrew E. Scott, Mitali Sarkar-Tyson, Philip M. Ireland, Helen L Bullifent, Z. Rong Yang, Karen Moore, Petra C. F. Oyston, Timothy P. Atkins, Helen S. Atkins, Orkun S. Soyer and Richard W. Titball

    Citation: BMC Microbiology 2017 17:163

    Content type: Research article

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  32. Group B Streptococcus (GBS) is a major cause of invasive disease especially in neonates. In GBS three structurally distinct pilus polymers have been identified as important virulence factors and promising vacc...

    Authors: Maddalena Lazzarin, Rong Mu, Monica Fabbrini, Claudia Ghezzo, C. Daniela Rinaudo, Kelly S. Doran and Immaculada Margarit

    Citation: BMC Microbiology 2017 17:148

    Content type: Research article

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  33. The objective of this study was to better understand the effects of soluble factors from biofilm of single- and mixed-species Candida albicans (C. albicans) and methicillin-sensitive Staphylococcus aureus (MSSA) ...

    Authors: Kassia de Carvalho Dias, Paula Aboud Barbugli, Fernanda de Patto, Virginia Barreto Lordello, Letícia de Aquino Penteado, Alexandra Ivo Medeiros and Carlos Eduardo Vergani

    Citation: BMC Microbiology 2017 17:146

    Content type: Research article

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  34. The phytopathogenic Xanthomonas campestris pv.campestris is a gram-negative bacterium and the causal agent of black-rot disease of cruciferous crops. Many gram-negative bacteria possess a family of proteins, call...

    Authors: Lei Chen, Mingpeng Wang, Li Huang, Zhaojie Zhang, Fanghua Liu and Guangtao Lu

    Citation: BMC Microbiology 2017 17:142

    Content type: Research article

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  35. The work was undertaken to expand the tools available for researching Burkholderia pseudomallei (Bp), the etiological agent of the tropical disease melioidosis. Melioidosis has the potential to pose a severe thre...

    Authors: Michael H. Norris, Md Siddiqur Rahman Khan, Herbert P. Schweizer and Apichai Tuanyok

    Citation: BMC Microbiology 2017 17:132

    Content type: Research article

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  36. Urinary tract infections (UTI) are among the most common and costly infections in both hospitalized and ambulatory patients. Uropathogenic E. coli (UPEC) represent the majority of UTI isolates and are a diverse g...

    Authors: Jason E. Michaud, Kwang Sik Kim, William Harty, Matthew Kasprenski and Ming-Hsien Wang

    Citation: BMC Microbiology 2017 17:127

    Content type: Research article

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  37. Brucellosis is a severe zoonotic disease worldwide. Detection and identification of Brucella species are essential to prevent or treat brucellosis in humans and animals. The outer membrane protein-31 (Omp31) is a...

    Authors: Jinfeng Li, Feihuan Hu, Shouyi Chen, Peifang Luo, Zuoping He, Wenjing Wang, Jean-Pierre Allain and Chengyao Li

    Citation: BMC Microbiology 2017 17:115

    Content type: Research article

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  38. During infection of the urinary tract, uropathogenic Escherichia coli (UPEC) are exposed to different environments, such as human urine and the intracellular environments of bladder epithelial cells. Each environ...

    Authors: Michelle Madelung, Tina Kronborg, Thomas Koed Doktor, Carsten Struve, Karen Angeliki Krogfelt and Jakob Møller-Jensen

    Citation: BMC Microbiology 2017 17:99

    Content type: Research article

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  39. Colonization of the body is an important step in Staphylococcus aureus infection. S. aureus colonizes skin and mucous membranes in humans and several animal species. One important ecological niche of S. aureus is...

    Authors: Anne-Merethe Hanssen, Bert Kindlund, Niels Christian Stenklev, Anne-Sofie Furberg, Silje Fismen, Renate Slind Olsen, Mona Johannessen and Johanna Ulrica Ericson Sollid

    Citation: BMC Microbiology 2017 17:89

    Content type: Research article

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  40. Critical to the development of Salmonellosis in humans is the interaction of the bacterium with the epithelial lining of the gastrointestinal tract. Traditional scientific reasoning held type III secretion sys...

    Authors: Kevin Howe, Sanaz Salehi, R. Hartford Bailey, John P. Brooks, Robert Wills, Mark L. Lawrence and Attila Karsi

    Citation: BMC Microbiology 2017 17:88

    Content type: Research article

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  41. Our previous research on the diversity of microbiota in the endotracheal tubes (ETTs) of neonates in the neonatal intensive care unit found that Pseudomonas aeruginosa (P. aeruginosa) and Streptococcus mitis (S. ...

    Authors: Chao Song, Hongdong Li, Yunhui Zhang and Jialin Yu

    Citation: BMC Microbiology 2017 17:82

    Content type: Research article

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  42. Enteroinvasive Escherichia coli (EIEC) may be the causative agent of part of those million cases of diarrhea illness reported worldwide every year and attributable to Shigella. That is because both enteropathogen...

    Authors: Laís Cristina da Silva, Ana Carolina de Mello Santos and Rosa Maria Silva

    Citation: BMC Microbiology 2017 17:68

    Content type: Research article

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  43. Probiotic bacteria are known to modulate host immune responses against various pathogens. Recently, extracellular vesicles (EVs) have emerged as potentially important mediators of host-pathogen interactions. I...

    Authors: Ming Li, Kiho Lee, Min Hsu, Gerard Nau, Eleftherios Mylonakis and Bharat Ramratnam

    Citation: BMC Microbiology 2017 17:66

    Content type: Research article

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  44. The aim of this study was to evaluate the effects of β-glucan on the expression of inflammatory mediators and metabolomic profile of oral cells [keratinocytes (OBA-9) and fibroblasts (HGF-1) in a dual-chamber ...

    Authors: Viviam de Oliveira Silva, Luciano José Pereira and Ramiro Mendonça Murata

    Citation: BMC Microbiology 2017 17:53

    Content type: Research article

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