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Microbe-host interactions and microbial pathogenicity

This section aims to publish studies looking at all aspects of microbe-host interactions and pathogenicity including pathogenic mechanisms, virulence factors, host invasion, immune evasion, host defence, immunity, immunology and symbiotic interactions.

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  1. The human gastrointestinal (GI) tract microbiota has been a subject of intense research throughout the 3rd Millennium. Now that a general picture about microbiota composition in health and disease is emerging,...

    Authors: Oula Peñate-Medina, Robert J. Tower, Tuula Peñate-Medina, Olga Will, Per E. J. Saris, Juho Suojanen, Timo Sorsa, Laura Huuskonen, Kaisa Hiippala, Reetta Satokari, Claus C. Glüer, Willem M. de Vos and Justus Reunanen

    Citation: BMC Microbiology 2019 19:167

    Content type: Research article

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  2. Enteric pathogens have developed mechanisms to disrupt tight junctions and increase gut permeability. Many studies have analysed the ability of live probiotics to protect intestinal epithelial cells against ti...

    Authors: Carina-Shianya Alvarez, Rosa Giménez, María-Alexandra Cañas, Rodrigo Vera, Natalia Díaz-Garrido, Josefa Badia and Laura Baldomà

    Citation: BMC Microbiology 2019 19:166

    Content type: Research article

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  3. We previously identified a plant-derived phenolic compound ortho-coumaric acid (OCA) as an inhibitor of type III secretion system (T3SS) of Xanthomonas oryzae pv. oryzae (Xoo), the pathogen causing bacterial leaf...

    Authors: Susu Fan, Fang Tian, Liwei Fang, Ching-Hong Yang and Chenyang He

    Citation: BMC Microbiology 2019 19:163

    Content type: Research article

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  4. H. pylori exhibits antibiotic resistance with regional differences. In this paper, we explored antibiotic resistance of H. pylori to five antibiotics in an area with a high risk of gastric cancer.

    Authors: Dan Wang, Qianqian Guo, Yuan Yuan and Yuehua Gong

    Citation: BMC Microbiology 2019 19:152

    Content type: Research article

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  5. Adaptability to different environmental conditions is an essential characteristic of pathogenic microorganisms as it facilitates their invasion of host organisms. The most external component of pathogenic yeas...

    Authors: Justyna Karkowska-Kuleta, Dorota Satala, Oliwia Bochenska, Maria Rapala-Kozik and Andrzej Kozik

    Citation: BMC Microbiology 2019 19:149

    Content type: Research article

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  6. The brown planthopper (BPH) is likely the most destructive, piercing and sucking monophagous insect pest of rice that causes substantial economic losses to farmers. Although yeast-like symbionts (YLS) and virus t...

    Authors: Abhishek Ojha and Wenqing Zhang

    Citation: BMC Microbiology 2019 19:139

    Content type: Research article

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  7. Pseudomonas aeruginosa is an opportunistic pathogen and one of the leading causes of nosocomial infections. Moreover, the species can cause severe infections in cystic fibrosis patients, in burnt victims and caus...

    Authors: Anna Cristhina Carmine de Melo, Amanda da Mata Gomes, Fernando L. Melo, Daniel M. P. Ardisson-Araújo, Agueda Palmira Castagna de Vargas, Valessa Lunkes Ely, Elliot W. Kitajima, Bergmann M. Ribeiro and José Luiz Caldas Wolff

    Citation: BMC Microbiology 2019 19:134

    Content type: Research article

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  8. Xenorhabdus spp. live in close symbiosis with nematodes of the Steinernema genus. Steinernema nematodes infect an insect larva and release their symbionts into the haemocoel of the insect. Once released into the ...

    Authors: J. Dreyer, M. Rautenbach, E. Booysen, A. D. van Staden, S. M. Deane and L. M. T. Dicks

    Citation: BMC Microbiology 2019 19:132

    Content type: Research article

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  9. Treatment with the α-glucosidase inhibitor acarbose increases median lifespan by approximately 20% in male mice and 5% in females. This longevity extension differs from dietary restriction based on a number of fe...

    Authors: Byron J Smith, Richard A Miller, Aaron C Ericsson, David C Harrison, Randy Strong and Thomas M Schmidt

    Citation: BMC Microbiology 2019 19:130

    Content type: Research article

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  10. Enteric methane from the ruminant livestock is a significant source in global greenhouse gas emissions, which is mainly generated by the methanogens inhabiting the rumen and cecum. Sika deer (Cervus nippon) not o...

    Authors: Zhipeng Li, Xiaoxu Wang, Ting Zhang, Huazhe Si, Chao Xu, André-Denis G. Wright and Guangyu Li

    Citation: BMC Microbiology 2019 19:129

    Content type: Research article

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  11. Gut microbes have been suggested as the possible targets in the management of allergic diseases. However, the way in which these microbes influence allergic diseases remain unclear. Forty-seven full-term newbo...

    Authors: Xi Shen, Maolin Wang, Xiao Zhang, Miao He, Ming Li, Guo Cheng, Chaomin Wan and Fang He

    Citation: BMC Microbiology 2019 19:123

    Content type: Research article

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  12. Bluetongue virus (BTV) causes a disease among wild and domesticated ruminants which is not contagious, but which is transmitted by biting midges of the Culicoides species. BTV can induce an intense cytopathic eff...

    Authors: Junzheng Du, Shandian Gao, Zhancheng Tian, Yanni Guo, Di Kang, Shanshan Xing, Guorui Zhang, Guangyuan Liu, Jianxun Luo, Huiyun Chang and Hong Yin

    Citation: BMC Microbiology 2019 19:121

    Content type: Research article

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  13. Trichosporon is the dominant genus of epidermal fungi in giant pandas (Ailuropoda melanoleuca) and causes local and deep infections. To provide the information needed for the diagnosis and treatment of trichospor...

    Authors: Xiaoping Ma, Yaozhang Jiang, Chengdong Wang, Yu Gu, Sanjie Cao, Xiaobo Huang, Yiping Wen, Qin Zhao, Rui Wu, Xintian Wen, Qigui Yan, Xinfeng Han, Zhicai Zuo, Junliang Deng, Zhihua Ren, Shumin Yu…

    Citation: BMC Microbiology 2019 19:113

    Content type: Research article

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  14. Knowledge of microbiota composition, persistence, and transmission as well as the overall function of the bacterial community is important and may be linked to honey bee health. This study aimed to investigate...

    Authors: Zuzana Hroncova, Jiri Killer, Josef Hakl, Dalibor Titera and Jaroslav Havlik

    Citation: BMC Microbiology 2019 19:110

    Content type: Research article

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  15. The abuse of antibiotics in animal husbandry imposes a serious threat to both animal health and the environment. As a replacement for antibiotics, probiotic products have been widely used in livestock farming ...

    Authors: Yongjia Peng, Qiumei Shi, Yujie Wang, Fan Zhang, Zhixin Ji and Jin Zhang

    Citation: BMC Microbiology 2019 19:109

    Content type: Research article

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  16. Cathepsins are a group of endosomal proteases present in many cells including dendritic cells (DCs). The activity of cathepsins is regulated by their endogenous inhibitors – cystatins. Cathepsins are crucial t...

    Authors: Magdalena Bossowska-Nowicka, Matylda B. Mielcarska, Marta Romaniewicz, Monika M. Kaczmarek, Karolina P. Gregorczyk-Zboroch, Justyna Struzik, Marta Grodzik, Małgorzata M. Gieryńska, Felix N. Toka and Lidia Szulc-Dąbrowska

    Citation: BMC Microbiology 2019 19:92

    Content type: Research article

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  17. Candidatus Berkiella cookevillensis’ and ‘Ca. Berkiella aquae’ have previously been described as intranuclear bacteria of amoebae. Both bacteria were isolated from amoebae and were described as appearing within...

    Authors: Nicholas B. Chamberlain, Yohannes T. Mehari, B. Jason Hayes, Colleen M. Roden, Destaalem T. Kidane, Andrew J. Swehla, Mario A. Lorenzana-DeWitt, Anthony L. Farone, John H. Gunderson, Sharon G. Berk and Mary B. Farone

    Citation: BMC Microbiology 2019 19:91

    Content type: Research article

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  18. Statistical evaluation of the association between microbial abundance and dietary variables can be done in various ways. Currently, there is no consensus on which methods are to be preferred in which circumsta...

    Authors: Xiang Zhang, Max Nieuwdorp, Albert K. Groen and Aeiko H. Zwinderman

    Citation: BMC Microbiology 2019 19:90

    Content type: Research article

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  19. Lactococcus lactis strain Plasma (LC-Plasma) possesses strong stimulatory activity for plasmacytoid dendritic cells (pDCs) via the TLR9-Myd88 pathway. To reveal the effective lactic acid bacteria (LAB) genome str...

    Authors: Akira Horie, Yasuyuki Tomita, Konomi Ohshio, Daisuke Fujiwara and Toshio Fujii

    Citation: BMC Microbiology 2019 19:88

    Content type: Research article

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  20. Both phylogeny and functional capabilities within the gut microbiota populations are of great importance for influencing host health. As a novel type of resistant starch, transglycosylated starch (TGS) modifie...

    Authors: Barbara U. Metzler-Zebeli, Monica A. Newman, Dietmar Grüll and Qendrim Zebeli

    Citation: BMC Microbiology 2019 19:87

    Content type: Research article

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  21. Anopheles mosquitoes are of great importance to human health. A number of studies have shown that midgut and salivary gland microflora have an impact on malaria parasite burden through colonization mechanisms, in...

    Authors: Abib Berhanu, Adugna Abera, Desalegn Nega, Sindew Mekasha, Surafel Fentaw, Abebe Assefa, Gashaw Gebrewolde, Yonas Wuletaw, Ashenafi Assefa, Sisay Dugassa, Habte Tekie and Geremew Tasew

    Citation: BMC Microbiology 2019 19:85

    Content type: Research article

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  22. The emergence of carbapenem-resistant Enterobacteriaceae strains has posed a severe threat to public health in recent years. The mobile elements carrying the New Delhi metallo-β-lactqtamase (NDM) gene have been r...

    Authors: Biao Tang, Jiang Chang, Liujie Cao, Qixia Luo, Hao Xu, Wentao Lyu, Mingrong Qian, Xiaofeng Ji, Qiaoyan Zhang, Xiaodong Xia and Hua Yang

    Citation: BMC Microbiology 2019 19:82

    Content type: Research article

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  23. The use of chemical fungicides against fungal pathogens adversely affects soil and plant health thereby resulting in overall environmental hazards. Therefore, biological source for obtaining antifungal agents ...

    Authors: Dibya Jyoti Hazarika, Gunajit Goswami, Trishnamoni Gautom, Assma Parveen, Pompi Das, Madhumita Barooah and Robin Chandra Boro

    Citation: BMC Microbiology 2019 19:71

    Content type: Research article

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  24. Neisseria gonorrhoeae is an obligate human pathogen and its adherence to host cells is essential for its pathogenesis. Gonococcal adherence assays are based on the enumeration of bacteria attached to human cells ...

    Authors: Sidharath Dev Thakur, Milan Obradovic, Jo-Anne R. Dillon, Siew Hon Ng and Heather L. Wilson

    Citation: BMC Microbiology 2019 19:67

    Content type: Methodology article

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  25. A majority of women with polycystic ovary syndrome (PCOS) have metabolic dysfunction that results in an increased risk of type 2 diabetes. We previously developed a pubertal mouse model using the aromatase inh...

    Authors: Pedro J. Torres, Danalea V. Skarra, Bryan S. Ho, Lillian Sau, Arya R. Anvar, Scott T. Kelley and Varykina G. Thackray

    Citation: BMC Microbiology 2019 19:57

    Content type: Research article

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  26. Edwardsiella ictaluri is a Gram-negative facultative intracellular anaerobe and the etiologic agent of enteric septicemia of channel catfish (ESC). To the catfish industry, ESC is a devastating disease due to pro...

    Authors: Safak Kalindamar, Jingjun Lu, Hossam Abdelhamed, Hasan C. Tekedar, Mark L. Lawrence and Attila Karsi

    Citation: BMC Microbiology 2019 19:55

    Content type: Research article

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  27. Bird species worldwide are affected by trichomoniasis caused by the protist Trichomonas gallinae. In avivorous raptors such as Cooper’s hawks (Accipiter cooperii), nestlings are more susceptible than fledglings a...

    Authors: Michael J. Taylor, R. William Mannan, Jana M. U’Ren, Nicholas P. Garber, Rachel E. Gallery and A. Elizabeth Arnold

    Citation: BMC Microbiology 2019 19:47

    Content type: Research article

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  28. Insects frequently live in close relationship with symbiotic bacteria that carry out beneficial functions for their host, like protection against parasites and viruses. However, in some cases, the mutualistic ...

    Authors: Mario Gonzalo Garcia-Arraez, Florent Masson, Juan Camilo Paredes Escobar and Bruno Lemaitre

    Citation: BMC Microbiology 2019 19:46

    Content type: Research article

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  29. Colon cancer is the third most commonly diagnosed cancer worldwide, with a commensurately high mortality rate. The search for novel antioxidants and specific anticancer agents which may inhibit, delay or rever...

    Authors: Loh Teng-Hern Tan, Kok-Gan Chan, Priyia Pusparajah, Wai-Fong Yin, Tahir Mehmood Khan, Learn-Han Lee and Bey-Hing Goh

    Citation: BMC Microbiology 2019 19:38

    Content type: Research article

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  30. Single stranded ribonucleic acid (ssRNA) binds to toll-like receptor (TLR)7 leading to recruitment of immune cells and production of pro-inflammatory cytokines, which has been shown in mammals. In chickens, sy...

    Authors: Mohamed Sarjoon Abdul-Cader, Upasama De Silva Senapathi, Hanaa Ahmed-Hassan, Shayan Sharif and Mohamed Faizal Abdul-Careem

    Citation: BMC Microbiology 2019 19:34

    Content type: Research article

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  31. Lactobacillus mucosae DPC 6426 has previously demonstrated potentially cardio-protective properties, in the form of dyslipidaemia and hypercholesterolemia correction in an apolipoprotein-E deficient mouse model. ...

    Authors: Paul M. Ryan, Ellen H. Stolte, Lis E. E. London, Jerry M. Wells, Sarah L. Long, Susan A. Joyce, Cormac G. M. Gahan, Gerald F. Fitzgerald, R. Paul Ross, Noel M. Caplice and Catherine Stanton

    Citation: BMC Microbiology 2019 19:33

    Content type: Research article

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  32. Leishmania (L.) spp are intracellular eukaryotic parasites responsible for cutaneous or visceral leishmaniasis, replicating predominantly in macrophages (MF). In C57BL/6 mice virulence with L. amazonensis has bee...

    Authors: Emilie Giraud, Eline Rouault, Laurence Fiette, Jean-Hervé Colle, Despoina Smirlis and Evie Melanitou

    Citation: BMC Microbiology 2019 19:32

    Content type: Research article

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  33. Diphtheria toxin (DT) is produced by toxigenic strains of the human pathogen Corynebacterium diphtheriae as well as zoonotic C. ulcerans and C. pseudotuberculosis. Toxigenic strains may cause severe respiratory d...

    Authors: Alexandra Dangel, Anja Berger, Regina Konrad and Andreas Sing

    Citation: BMC Microbiology 2019 19:28

    Content type: Research article

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  34. Francisella noatunensis subsp. orientalis (Fno) is an emergent fish pathogen and the etiologic agent of piscine francisellosis. Besides persisting in the environment in both biofilm and planktonic forms, Fno is k...

    Authors: Jainee Lewis and Esteban Soto

    Citation: BMC Microbiology 2019 19:21

    Content type: Research article

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  35. Obesity is known to modulate human health in a number of ways including altering the microbiome of the gut. Very few studies have examined the how obesity may affect the microbiomes of sites distant to the gut...

    Authors: Rebecca Vongsa, Doug Hoffman, Kristin Shepard and David Koenig

    Citation: BMC Microbiology 2019 19:16

    Content type: Research article

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  36. Human adenovirus (Ad) infection leads to the changes of host cell gene expression and biosynthetic processes. Transcriptomics in adenovirus type 2 (Ad2)-infected lung fibroblasts (IMR-90) cells has previously ...

    Authors: Hongxing Zhao, Maoshan Chen, Alberto Valdés, Sara Bergström Lind and Ulf Pettersson

    Citation: BMC Microbiology 2019 19:15

    Content type: Research article

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  37. Cytokines play a vital role in the host immune response to infection by initiating the healing process and/or accelerating the progression of the disease in cutaneous leishmaniasis (CL). Very little evidence i...

    Authors: Lahiru Sandaruwan Galgamuwa, Buthsiri Sumanasena, Devika Iddawela, Susiji Wickramasinghe and Lalani Yatawara

    Citation: BMC Microbiology 2019 19:14

    Content type: Research article

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  38. Leptospirosis is a widespread zoonosis caused by pathogenic prokaryotic microbes of the genus Leptospira. Although there are several reports in the literature, host-pathogen interaction is still poorly understood...

    Authors: Paloma L. da Silva, Fabiana Lauretti-Ferreira, Maiara Caldas de Lima, Swiany Silveira Lima, Ambart E. Covarrubias, Marcelo De Franco, Eneas Carvalho, Paulo Lee Ho, Renata M. A. da Costa, Elizabeth A. L. Martins and Josefa B. Da Silva

    Citation: BMC Microbiology 2019 19:4

    Content type: Research article

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  39. Sugarcane is an important sugar and economic crop in the world. Ratoon stunting Disease (RSD) of sugarcane, caused by Leifsonia xyli subsp. xyli, is widespread in countries and regions where sugarcane is grown an...

    Authors: Kai Zhu, Min Shao, Dan Zhou, Yong-Xiu Xing, Li-Tao Yang and Yang-Rui Li

    Citation: BMC Microbiology 2019 19:2

    Content type: Research article

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  40. Little is known regarding the nasal microbiome in early childhood and the impact of respiratory infection on the infants’ nasal microbial composition. Here we investigated the temporal dynamics and diversity o...

    Authors: Mahrrouz Caputo, Beate Zoch-Lesniak, André Karch, Marius Vital, Frederic Meyer, Frank Klawonn, Armin Baillot, Dietmar H. Pieper and Rafael T. Mikolajczyk

    Citation: BMC Microbiology 2019 19:1

    Content type: Research article

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  41. Bovine ephemeral fever virus (BEFV), the causative agent of bovine ephemeral fever, is an economically important pathogen of cattle and water buffalo. MicroRNAs (miRNAs) are endogenous 21-23 nt small non-codin...

    Authors: Peili Hou, Hongmei Wang, Guimin Zhao, Guixue Hu, Xianzhu Xia and Hongbin He

    Citation: BMC Microbiology 2018 18:224

    Content type: Research article

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  42. We performed a 12-month cohort study of the stability and resilience of the intestinal microbiota of healthy children in daycare in Denmark in relation to diarrheal events and exposure to known risk factors fo...

    Authors: Martin Steen Mortensen, Betina Hebbelstrup Jensen, Jeanne Williams, Asker Daniel Brejnrod, Lee O’Brien Andersen, Dennis Röser, Bente Utoft Andreassen, Andreas Munk Petersen, Christen Rune Stensvold, Søren Johannes Sørensen and Karen Angeliki Krogfelt

    Citation: BMC Microbiology 2018 18:223

    Content type: Research article

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  43. Appreciable evidence suggest that dysbiosis in microbiota, reflected in gut microbial imbalance plays a key role in the pathogenesis of neuropsychiatric disorders including depression and inflammatory diseases...

    Authors: Bruk Getachew, Joseph I. Aubee, Richard S. Schottenfeld, Antonei B. Csoka, Karl M. Thompson and Yousef Tizabi

    Citation: BMC Microbiology 2018 18:222

    Content type: Research article

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  44. Tibetan sheep (TS) and Gansu Alpine Finewool sheep (GS) are both important plateau sheep raised and fed on the harsh Qinghai–Tibetan Plateau, China. Rumen methanogen and protozoal communities of plateau sheep ...

    Authors: Jinqiang Huang and Yongjuan Li

    Citation: BMC Microbiology 2018 18:212

    Content type: Research article

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  45. Modifiable lifestyle factors (e.g. dietary intake and physical activity) are important contributors to weight gain during college. The purpose of this study was to evaluate whether associations exist between b...

    Authors: Corrie M. Whisner, Juan Maldonado, Brandon Dente, Rosa Krajmalnik-Brown and Meg Bruening

    Citation: BMC Microbiology 2018 18:210

    Content type: Research article

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  46. The study describes the Salmonella Rissen phage ϕ1 isolated from the ϕ1-sensitive Salmonella Rissen strain RW. The same phage was then used to select the resistant strain RRϕ1+, which can harbour or not ϕ1.

    Authors: Marina Papaianni, Felice Contaldi, Andrea Fulgione, Sheridan L. Woo, Angela Casillo, Maria Michela Corsaro, Ermenegilda Parrilli, Luca Marcolungo, Marzia Rossato, Massimo Delledonne, Marianna Garonzi, Domenico Iannelli and Rosanna Capparelli

    Citation: BMC Microbiology 2018 18:208

    Content type: Research article

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  47. Composition of the vaginal microbiota has significant influence on female urogenital health and control of infectious disease. Murine models are widely utilized to characterize host-pathogen interactions withi...

    Authors: Alison Vrbanac, Angelica M. Riestra, Alison Coady, Rob Knight, Victor Nizet and Kathryn A. Patras

    Citation: BMC Microbiology 2018 18:197

    Content type: Research article

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