Microbe-host interactions and microbial pathogenicity

Section edited by David Nelson

This section aims to publish studies looking at all aspects of microbe-host interactions and pathogenicity including pathogenic mechanisms, virulence factors, host invasion, immune evasion, host defence, immunity, immunology and symbiotic interactions.

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  1. Research article

    Acute Penicillium marneffei infection stimulates host M1/M2a macrophages polarization in BALB/C mice

    Penicillium marneffei (P. marneffei) is a thermally dimorphic fungus pathogen that causes fatal infection. Alveolar macrophages are innate immune cells that have critical roles in prot...

    Xiaoying Dai, Congzheng Mao, Xiuwan Lan, Huan Chen, Meihua Li, Jing Bai, Jingmin Deng, Qiuli Liang, Jianquan Zhang, Xiaoning Zhong, Yi Liang, Jiangtao Fan, Honglin Luo and Zhiyi He

    BMC Microbiology 2017 17:177

    Published on: 18 August 2017

  2. Research article

    Administration of two probiotic strains during early childhood does not affect the endogenous gut microbiota composition despite probiotic proliferation

    Probiotics are increasingly applied to prevent and treat a range of infectious, immune related and gastrointestinal diseases. Despite this, the mechanisms behind the putative effects of probiotics are poorly u...

    Martin Frederik Laursen, Rikke Pilmann Laursen, Anni Larnkjær, Kim F. Michaelsen, Martin Iain Bahl and Tine Rask Licht

    BMC Microbiology 2017 17:175

    Published on: 17 August 2017

  3. Research article

    An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions

    The World Health Organization has categorized plague as a re-emerging disease and the potential for Yersinia pestis to also be used as a bioweapon makes the identification of new drug targets against this pathoge...

    Nicola J. Senior, Kalesh Sasidharan, Richard J. Saint, Andrew E. Scott, Mitali Sarkar-Tyson, Philip M. Ireland, Helen L Bullifent, Z. Rong Yang, Karen Moore, Petra C. F. Oyston, Timothy P. Atkins, Helen S. Atkins, Orkun S. Soyer and Richard W. Titball

    BMC Microbiology 2017 17:163

    Published on: 21 July 2017

  4. Research article

    Contribution of pilus type 2b to invasive disease caused by a Streptococcus agalactiae ST-17 strain

    Group B Streptococcus (GBS) is a major cause of invasive disease especially in neonates. In GBS three structurally distinct pilus polymers have been identified as important virulence factors and promising vacc...

    Maddalena Lazzarin, Rong Mu, Monica Fabbrini, Claudia Ghezzo, C. Daniela Rinaudo, Kelly S. Doran and Immaculada Margarit

    BMC Microbiology 2017 17:148

    Published on: 3 July 2017

  5. Research article

    Soluble factors from biofilm of Candida albicans and Staphylococcus aureus promote cell death and inflammatory response

    The objective of this study was to better understand the effects of soluble factors from biofilm of single- and mixed-species Candida albicans (C. albicans) and methicillin-sensitive Staphylococcus aureus (MSSA) ...

    Kassia de Carvalho Dias, Paula Aboud Barbugli, Fernanda de Patto, Virginia Barreto Lordello, Letícia de Aquino Penteado, Alexandra Ivo Medeiros and Carlos Eduardo Vergani

    BMC Microbiology 2017 17:146

    Published on: 30 June 2017

  6. Research article

    XC_0531 encodes a c-type cytochrome biogenesis protein and is required for pathogenesis in Xanthomonas campestris pv. campestris

    The phytopathogenic Xanthomonas campestris pv.campestris is a gram-negative bacterium and the causal agent of black-rot disease of cruciferous crops. Many gram-negative bacteria possess a family of proteins, call...

    Lei Chen, Mingpeng Wang, Li Huang, Zhaojie Zhang, Fanghua Liu and Guangtao Lu

    BMC Microbiology 2017 17:142

    Published on: 27 June 2017

  7. Research article

    An avirulent Burkholderia pseudomalleipurM strain with atypical type B LPS: expansion of the toolkit for biosafe studies of melioidosis

    The work was undertaken to expand the tools available for researching Burkholderia pseudomallei (Bp), the etiological agent of the tropical disease melioidosis. Melioidosis has the potential to pose a severe thre...

    Michael H. Norris, Md Siddiqur Rahman Khan, Herbert P. Schweizer and Apichai Tuanyok

    BMC Microbiology 2017 17:132

    Published on: 7 June 2017

  8. Research article

    Cytotoxic Necrotizing Factor-1 (CNF1) does not promote E. coli infection in a murine model of ascending pyelonephritis

    Urinary tract infections (UTI) are among the most common and costly infections in both hospitalized and ambulatory patients. Uropathogenic E. coli (UPEC) represent the majority of UTI isolates and are a diverse g...

    Jason E. Michaud, Kwang Sik Kim, William Harty, Matthew Kasprenski and Ming-Hsien Wang

    BMC Microbiology 2017 17:127

    Published on: 25 May 2017

  9. Research article

    Characterization of novel Omp31 antigenic epitopes of Brucella melitensis by monoclonal antibodies

    Brucellosis is a severe zoonotic disease worldwide. Detection and identification of Brucella species are essential to prevent or treat brucellosis in humans and animals. The outer membrane protein-31 (Omp31) is a...

    Jinfeng Li, Feihuan Hu, Shouyi Chen, Peifang Luo, Zuoping He, Wenjing Wang, Jean-Pierre Allain and Chengyao Li

    BMC Microbiology 2017 17:115

    Published on: 15 May 2017

  10. Research article

    DFI-seq identification of environment-specific gene expression in uropathogenic Escherichia coli

    During infection of the urinary tract, uropathogenic Escherichia coli (UPEC) are exposed to different environments, such as human urine and the intracellular environments of bladder epithelial cells. Each environ...

    Michelle Madelung, Tina Kronborg, Thomas Koed Doktor, Carsten Struve, Karen Angeliki Krogfelt and Jakob Møller-Jensen

    BMC Microbiology 2017 17:99

    Published on: 24 April 2017

  11. Research article

    Supplemental invasion of Salmonella from the perspective of Salmonella enterica serovars Kentucky and Typhimurium

    Critical to the development of Salmonellosis in humans is the interaction of the bacterium with the epithelial lining of the gastrointestinal tract. Traditional scientific reasoning held type III secretion sys...

    Kevin Howe, Sanaz Salehi, R. Hartford Bailey, John P. Brooks, Robert Wills, Mark L. Lawrence and Attila Karsi

    BMC Microbiology 2017 17:88

    Published on: 5 April 2017

  12. Research article

    Localization of Staphylococcus aureus in tissue from the nasal vestibule in healthy carriers

    Colonization of the body is an important step in Staphylococcus aureus infection. S. aureus colonizes skin and mucous membranes in humans and several animal species. One important ecological niche of S. aureus is...

    Anne-Merethe Hanssen, Bert Kindlund, Niels Christian Stenklev, Anne-Sofie Furberg, Silje Fismen, Renate Slind Olsen, Mona Johannessen and Johanna Ulrica Ericson Sollid

    BMC Microbiology 2017 17:89

    Published on: 5 April 2017

  13. Research article

    Uropathogenic Escherichia coli pathogenicity islands and other ExPEC virulence genes may contribute to the genome variability of enteroinvasive E. coli

    Enteroinvasive Escherichia coli (EIEC) may be the causative agent of part of those million cases of diarrhea illness reported worldwide every year and attributable to Shigella. That is because both enteropathogen...

    Laís Cristina da Silva, Ana Carolina de Mello Santos and Rosa Maria Silva

    BMC Microbiology 2017 17:68

    Published on: 16 March 2017

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