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Microbe-host interactions and microbial pathogenicity

Section edited by David Nelson

This section aims to publish studies looking at all aspects of microbe-host interactions and pathogenicity including pathogenic mechanisms, virulence factors, host invasion, immune evasion, host defence, immunity, immunology and symbiotic interactions.

Page 1 of 8

  1. Content type: Research article

    Colon cancer is the third most commonly diagnosed cancer worldwide, with a commensurately high mortality rate. The search for novel antioxidants and specific anticancer agents which may inhibit, delay or rever...

    Authors: Loh Teng-Hern Tan, Kok-Gan Chan, Priyia Pusparajah, Wai-Fong Yin, Tahir Mehmood Khan, Learn-Han Lee and Bey-Hing Goh

    Citation: BMC Microbiology 2019 19:38

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  2. Content type: Research article

    Leishmania (L.) spp are intracellular eukaryotic parasites responsible for cutaneous or visceral leishmaniasis, replicating predominantly in macrophages (MF). In C57BL/6 mice virulence with L. amazonensis has bee...

    Authors: Emilie Giraud, Eline Rouault, Laurence Fiette, Jean-Hervé Colle, Despoina Smirlis and Evie Melanitou

    Citation: BMC Microbiology 2019 19:32

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  3. Content type: Research article

    Lactobacillus mucosae DPC 6426 has previously demonstrated potentially cardio-protective properties, in the form of dyslipidaemia and hypercholesterolemia correction in an apolipoprotein-E deficient mouse model. ...

    Authors: Paul M. Ryan, Ellen H. Stolte, Lis E. E. London, Jerry M. Wells, Sarah L. Long, Susan A. Joyce, Cormac G. M. Gahan, Gerald F. Fitzgerald, R. Paul Ross, Noel M. Caplice and Catherine Stanton

    Citation: BMC Microbiology 2019 19:33

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  4. Content type: Research article

    Single stranded ribonucleic acid (ssRNA) binds to toll-like receptor (TLR)7 leading to recruitment of immune cells and production of pro-inflammatory cytokines, which has been shown in mammals. In chickens, sy...

    Authors: Mohamed Sarjoon Abdul-Cader, Upasama De Silva Senapathi, Hanaa Ahmed-Hassan, Shayan Sharif and Mohamed Faizal Abdul-Careem

    Citation: BMC Microbiology 2019 19:34

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  5. Content type: Research article

    Diphtheria toxin (DT) is produced by toxigenic strains of the human pathogen Corynebacterium diphtheriae as well as zoonotic C. ulcerans and C. pseudotuberculosis. Toxigenic strains may cause severe respiratory d...

    Authors: Alexandra Dangel, Anja Berger, Regina Konrad and Andreas Sing

    Citation: BMC Microbiology 2019 19:28

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  6. Content type: Research article

    Francisella noatunensis subsp. orientalis (Fno) is an emergent fish pathogen and the etiologic agent of piscine francisellosis. Besides persisting in the environment in both biofilm and planktonic forms, Fno is k...

    Authors: Jainee Lewis and Esteban Soto

    Citation: BMC Microbiology 2019 19:21

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  7. Content type: Research article

    Obesity is known to modulate human health in a number of ways including altering the microbiome of the gut. Very few studies have examined the how obesity may affect the microbiomes of sites distant to the gut...

    Authors: Rebecca Vongsa, Doug Hoffman, Kristin Shepard and David Koenig

    Citation: BMC Microbiology 2019 19:16

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  8. Content type: Research article

    Cytokines play a vital role in the host immune response to infection by initiating the healing process and/or accelerating the progression of the disease in cutaneous leishmaniasis (CL). Very little evidence i...

    Authors: Lahiru Sandaruwan Galgamuwa, Buthsiri Sumanasena, Devika Iddawela, Susiji Wickramasinghe and Lalani Yatawara

    Citation: BMC Microbiology 2019 19:14

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  9. Content type: Research article

    Human adenovirus (Ad) infection leads to the changes of host cell gene expression and biosynthetic processes. Transcriptomics in adenovirus type 2 (Ad2)-infected lung fibroblasts (IMR-90) cells has previously ...

    Authors: Hongxing Zhao, Maoshan Chen, Alberto Valdés, Sara Bergström Lind and Ulf Pettersson

    Citation: BMC Microbiology 2019 19:15

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  10. Content type: Research article

    Little is known regarding the nasal microbiome in early childhood and the impact of respiratory infection on the infants’ nasal microbial composition. Here we investigated the temporal dynamics and diversity o...

    Authors: Mahrrouz Caputo, Beate Zoch-Lesniak, André Karch, Marius Vital, Frederic Meyer, Frank Klawonn, Armin Baillot, Dietmar H. Pieper and Rafael T. Mikolajczyk

    Citation: BMC Microbiology 2019 19:1

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  11. Content type: Research article

    Leptospirosis is a widespread zoonosis caused by pathogenic prokaryotic microbes of the genus Leptospira. Although there are several reports in the literature, host-pathogen interaction is still poorly understood...

    Authors: Paloma L. da Silva, Fabiana Lauretti-Ferreira, Maiara Caldas de Lima, Swiany Silveira Lima, Ambart E. Covarrubias, Marcelo De Franco, Eneas Carvalho, Paulo Lee Ho, Renata M. A. da Costa, Elizabeth A. L. Martins and Josefa B. Da Silva

    Citation: BMC Microbiology 2019 19:4

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  12. Content type: Research article

    Sugarcane is an important sugar and economic crop in the world. Ratoon stunting Disease (RSD) of sugarcane, caused by Leifsonia xyli subsp. xyli, is widespread in countries and regions where sugarcane is grown an...

    Authors: Kai Zhu, Min Shao, Dan Zhou, Yong-Xiu Xing, Li-Tao Yang and Yang-Rui Li

    Citation: BMC Microbiology 2019 19:2

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  14. Content type: Research article

    Bovine ephemeral fever virus (BEFV), the causative agent of bovine ephemeral fever, is an economically important pathogen of cattle and water buffalo. MicroRNAs (miRNAs) are endogenous 21-23 nt small non-codin...

    Authors: Peili Hou, Hongmei Wang, Guimin Zhao, Guixue Hu, Xianzhu Xia and Hongbin He

    Citation: BMC Microbiology 2018 18:224

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  15. Content type: Research article

    We performed a 12-month cohort study of the stability and resilience of the intestinal microbiota of healthy children in daycare in Denmark in relation to diarrheal events and exposure to known risk factors fo...

    Authors: Martin Steen Mortensen, Betina Hebbelstrup Jensen, Jeanne Williams, Asker Daniel Brejnrod, Lee O’Brien Andersen, Dennis Röser, Bente Utoft Andreassen, Andreas Munk Petersen, Christen Rune Stensvold, Søren Johannes Sørensen and Karen Angeliki Krogfelt

    Citation: BMC Microbiology 2018 18:223

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  16. Content type: Research article

    Appreciable evidence suggest that dysbiosis in microbiota, reflected in gut microbial imbalance plays a key role in the pathogenesis of neuropsychiatric disorders including depression and inflammatory diseases...

    Authors: Bruk Getachew, Joseph I. Aubee, Richard S. Schottenfeld, Antonei B. Csoka, Karl M. Thompson and Yousef Tizabi

    Citation: BMC Microbiology 2018 18:222

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  17. Content type: Research article

    Tibetan sheep (TS) and Gansu Alpine Finewool sheep (GS) are both important plateau sheep raised and fed on the harsh Qinghai–Tibetan Plateau, China. Rumen methanogen and protozoal communities of plateau sheep ...

    Authors: Jinqiang Huang and Yongjuan Li

    Citation: BMC Microbiology 2018 18:212

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  18. Content type: Research article

    Modifiable lifestyle factors (e.g. dietary intake and physical activity) are important contributors to weight gain during college. The purpose of this study was to evaluate whether associations exist between b...

    Authors: Corrie M. Whisner, Juan Maldonado, Brandon Dente, Rosa Krajmalnik-Brown and Meg Bruening

    Citation: BMC Microbiology 2018 18:210

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  19. Content type: Research article

    The study describes the Salmonella Rissen phage ϕ1 isolated from the ϕ1-sensitive Salmonella Rissen strain RW. The same phage was then used to select the resistant strain RRϕ1+, which can harbour or not ϕ1.

    Authors: Marina Papaianni, Felice Contaldi, Andrea Fulgione, Sheridan L. Woo, Angela Casillo, Maria Michela Corsaro, Ermenegilda Parrilli, Luca Marcolungo, Marzia Rossato, Massimo Delledonne, Marianna Garonzi, Domenico Iannelli and Rosanna Capparelli

    Citation: BMC Microbiology 2018 18:208

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  20. Content type: Research article

    Composition of the vaginal microbiota has significant influence on female urogenital health and control of infectious disease. Murine models are widely utilized to characterize host-pathogen interactions withi...

    Authors: Alison Vrbanac, Angelica M. Riestra, Alison Coady, Rob Knight, Victor Nizet and Kathryn A. Patras

    Citation: BMC Microbiology 2018 18:197

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  21. Content type: Research article

    Theobroma cacao L. (cacao) is a perennial tropical tree, endemic to rainforests of the Amazon Basin. Large populations of bacteria live on leaf surfaces and these phylloplane microorganisms can have important eff...

    Authors: Juliano Oliveira Santana, Karina Peres Gramacho, Katiúcia Tícila de Souza Eduvirgens Ferreira, Rachel Passos Rezende, Pedro Antônio Oliveira Mangabeira, Ricardo Pedro Moreira Dias, Francisco M. Couto and Carlos Priminho Pirovani

    Citation: BMC Microbiology 2018 18:194

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  22. Content type: Research article

    16S rRNA gene amplicon sequencing analysis (16S amplicon sequencing) has provided considerable information regarding the ecology of the intestinal microbiome. Recently, metabolomics has been used for investiga...

    Authors: Yoshihisa Wakita, Yumi Shimomura, Yusuke Kitada, Hiroyuki Yamamoto, Yoshiaki Ohashi and Mitsuharu Matsumoto

    Citation: BMC Microbiology 2018 18:188

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  23. Content type: Research article

    Staphylococcus aureus is a leading cause of Gram-positive bacterial infections worldwide; however, the treatment of S. aureus infection has become increasingly difficult due to the prevalence of methicillin-resis...

    Authors: Chendi Jing, Chenghua Liu, Fangjie Liu, Yaping Gao, Yu Liu, Zhangchun Guan, Bo Xuan, Yanyan Yu and Guang Yang

    Citation: BMC Microbiology 2018 18:181

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  24. Content type: Research article

    Lactic acid bacteria (LAB) are major inhabitants and part of the normal microflora of the gastrointestinal tract (GIT) of humans and animals. Despite substantial evidence supporting the beneficial properties o...

    Authors: Winschau F. Van Zyl, Shelly M. Deane and Leon M. T. Dicks

    Citation: BMC Microbiology 2018 18:171

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  25. Content type: Research article

    The aim of this study was to identify Lactobacillus isolates derived from turkeys from six Polish farms and to characterize their phenotypic and genotypic antibiotic resistance profiles.

    Authors: Marta Dec, Anna Nowaczek, Dagmara Stępień-Pyśniak, Jacek Wawrzykowski and Renata Urban-Chmiel

    Citation: BMC Microbiology 2018 18:168

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  26. Content type: Methodology article

    Haemophilus influenzae is found in the nasopharynx of 80% of the human population. While colonisation with non-typeable Haemophilus influenzae (NTHi) is usually asymptomatic, it is capable of causing acute and ch...

    Authors: Stephen R. Thomas, Stephanie Leung, Katy Knox, Tom M. A. Wilkinson, Karl J. Staples, Pascal Lestrate, Dominique Wauters, Andrew Gorringe and Stephen C. Taylor

    Citation: BMC Microbiology 2018 18:167

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  27. Content type: Research article

    Vulvovaginal candidiasis (VVC) is a common infectious disease of the lower genital tract. Nystatin, a polyene fungicidal antibiotic, is used as a topical antifungal agent for VVC treatment. The aim of the curr...

    Authors: Xu Zhang, Ting Li, Xi Chen, Suxia Wang and Zhaohui Liu

    Citation: BMC Microbiology 2018 18:166

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  28. Content type: Research article

    Campylobacter jejuni (C. jejuni) is a leading cause of foodborne gastroenteritis worldwide. This bacterium lacks many of the classical virulence factors, and flagellum-associated persistent colonization has been ...

    Authors: Fangzhe Ren, Xiaofei Li, Haiyan Tang, Qidong Jiang, Xi Yun, Lin Fang, Pingyu Huang, Yuanyue Tang, Qiuchun Li, Jinlin Huang and Xin-an Jiao

    Citation: BMC Microbiology 2018 18:149

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  29. Content type: Methodology article

    Endothelial cells play a major role in highly pathogenic avian influenza (HPAI) virus pathogenesis in gallinaceous poultry species (e.g. chicken, turkey and quail). Upon infection of gallinaceous poultry with ...

    Authors: Raissa L. Davis, Geunho Choi, Thijs Kuiken, Pascale Quéré, Sascha Trapp, Kirsty R. Short and Mathilde Richard

    Citation: BMC Microbiology 2018 18:138

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  30. Content type: Research article

    Dickeya zeae is the causal agent of maize and rice foot rot diseases, but recently it was also found to infect banana and cause severe losses in China. Strains from different sources showed significant diversity ...

    Authors: Ming Hu, Jieling Li, Ruiting Chen, Wenjun Li, Luwen Feng, Lei Shi, Yang Xue, Xiaoyin Feng, Lianhui Zhang and Jianuan Zhou

    Citation: BMC Microbiology 2018 18:136

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  31. Content type: Research article

    Gut bacteria are closely associated with host. Chrysomya megacephala, as a vector and resource insect, can transmit various pathogenic bacteria and consume manure to produce biofertilizer and larva biomass. Howev...

    Authors: Xiaoyun Wang, Qiao Gao, Wanqiang Wang, Xiaoping Wang, Chaoliang Lei and Fen Zhu

    Citation: BMC Microbiology 2018 18:131

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  32. Content type: Research article

    Symbiosis in insects is accumulating significant amount of studies: the description of a wide array of mutualistic associations across the evolutionary history of insects suggests that resident microbiota acts...

    Authors: M V Mancini, C Damiani, A Accoti, M Tallarita, E Nunzi, A Cappelli, J Bozic, R Catanzani, P Rossi, M Valzano, A Serrao, I Ricci, R Spaccapelo and G Favia

    Citation: BMC Microbiology 2018 18:126

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  33. Content type: Research article

    Bacterial contamination remains the major problem in skin banks, even after antimicrobial treatment, and results in high rates of tissue discarding. This study aimed to analyze bacterial contamination in 32 hu...

    Authors: Karine Lena Meneghetti, Micaela do Canto Canabarro, Letícia Muner Otton, Thaís dos Santos Hain, Mercedes Passos Geimba and Gertrudes Corção

    Citation: BMC Microbiology 2018 18:121

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  34. Content type: Research article

    Aspergillus fumigatus is a ubiquitous saprotrophic fungus and an opportunistic pathogen of humans and animals. Humans and animals can inhale hundreds of A. fumigatus spores daily. Normally this is harmless for hu...

    Authors: Ivan D. Valdes, Joris van den Berg, Annika Haagsman, Natalia Escobar, Jacques F. Meis, Ferry Hagen, Pieter Jan Haas, Jos Houbraken, Han A. B. Wösten and Hans de Cock

    Citation: BMC Microbiology 2018 18:118

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  35. Content type: Research article

    Quorum sensing (QS) is a cell-to cell communication system that bacteria use to synchronize activities as a group. LitR, the master regulator of QS in Aliivibrio salmonicida, was recently shown to regulate activi...

    Authors: Miriam Khider, Nils Peder Willassen and Hilde Hansen

    Citation: BMC Microbiology 2018 18:116

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  36. Content type: Research article

    Asthma, one of the most common chronic respiratory disorders, is associated with the hyper-activation of the T-cell subset of adaptive immunity. The gut microbiota may be involved in the development of asthma ...

    Authors: Qi Wang, Fei Li, Bishan Liang, Yuhu Liang, Sijie Chen, Xiaodong Mo, Yanmei Ju, Hui Zhao, Huijue Jia, Timothy D. Spector, Hailiang Xie and Ruijin Guo

    Citation: BMC Microbiology 2018 18:114

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  37. Content type: Research article

    Dexamethasone (Dex), an artificially synthetic cortisol substitute, is commonly used as an anti-inflammatory drug, and is also employed to mimic the stress state experimentally. It is well known that chronic s...

    Authors: Canfeng Hua, Yali Geng, Qu Chen, Liqiong Niu, Liuping Cai, Shiyu Tao, Yingdong Ni and Ruqian Zhao

    Citation: BMC Microbiology 2018 18:112

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  38. Content type: Research article

    Campylobacter jejuni is one of the most common bacterial causes of food-borne enteritis worldwide. Chemotaxis in C. jejuni is known to be critical for the successful colonization of the host and key for the adapt...

    Authors: Anastasia-Lisa Lübke, Sabrina Minatelli, Thomas Riedel, Raimond Lugert, Isabel Schober, Cathrin Spröer, Jörg Overmann, Uwe Groß, Andreas E. Zautner and Wolfgang Bohne

    Citation: BMC Microbiology 2018 18:111

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  39. Content type: Research article

    The stability of intestinal microorganisms plays an important role in human health, as the intestines perform important functions in the human body. Staphylococcus aureus is a Gram-positive, facultative anaerobic...

    Authors: Dayong Ren, Shengjie Gong, Jingyan Shu, Jianwei Zhu, Hongyan Liu and Ping Chen

    Citation: BMC Microbiology 2018 18:109

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  40. Content type: Research article

    Corynebacterium diphtheriae is the etiologic agent of diphtheria and different systemic infections. The bacterium has been classically described as an extracellular pathogen. However, a number of studies revealed...

    Authors: Dulanthi Weerasekera, Franziska Stengel, Heinrich Sticht, Ana Luíza de Mattos Guaraldi, Andreas Burkovski and Camila Azevedo Antunes

    Citation: BMC Microbiology 2018 18:106

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  41. Content type: Research article

    The Gram-negative phytopathogenic bacterium Xanthomonas campestris pv. campestris recruits the hrp/T3SS system to inject pathogenicity effector proteins into host cells and uses the rpf/DSF cell-cell signaling sy...

    Authors: Bo-Le Jiang, Guo-Feng Jiang, Wei Liu, Li-Chao Yang, Li-Yan Yang, Lin Wang, Xiao-Hong Hang and Ji-Liang Tang

    Citation: BMC Microbiology 2018 18:103

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  42. Content type: Research article

    Phage therapy is the therapeutic use of bacteriophages to treat highly drug resistant bacterial infections. The current surge in bacteriophage therapy is motivated mainly because of the emergence of antibiotic...

    Authors: Prasanth Manohar, Ramesh Nachimuthu and Bruno S. Lopes

    Citation: BMC Microbiology 2018 18:97

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  43. Content type: Research article

    Colorectal cancer (CRC) is a common malignant gastrointestinal tumor. In China, CRC is the 5th most commonly diagnosed cancer. The vast majority of CRC cases are sporadic and evolve with the adenoma-carcinoma ...

    Authors: Yongzhen Zhang, Xin Yu, Enda Yu, Na Wang, Quancai Cai, Qun Shuai, Feihu Yan, Lufang Jiang, Hexing Wang, Jianxiang Liu, Yue Chen, Zhaoshen Li and Qingwu Jiang

    Citation: BMC Microbiology 2018 18:92

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  44. Content type: Research article

    Apple canker is a devastating branch disease caused by Valsa mali (Vm). The endophytic actinomycete Saccharothrix yanglingensis Hhs.015 (Sy Hhs.015) can effectively inhibit the growth of Vm. To reveal the mechani...

    Authors: Cong Liu, Dongying Fan, Yanfang Li, Yue Chen, Lili Huang and Xia Yan

    Citation: BMC Microbiology 2018 18:90

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  45. Content type: Research article

    Since recognizing the interaction between Brucella and host cells is crucial to the elucidation of the infectious process, Brucella researches have prioritized the investigation of genes related to pathogenicity....

    Authors: Myunghwan Jung, Soojin Shim, Young Bin Im, Woo Bin Park and Han Sang Yoo

    Citation: BMC Microbiology 2018 18:82

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  46. Content type: Research article

    Bovine tuberculosis (bTB) caused by Mycobacterium bovis is the most serious endemic disease affecting livestock in the UK. The European badger (Meles meles) is the most important wildlife reservoir of bTB transmi...

    Authors: Anna Stedman, Carlos Maluquer de Motes, Sandrine Lesellier, Deanna Dalley, Mark Chambers and Jorge Gutierrez-Merino

    Citation: BMC Microbiology 2018 18:74

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  48. Content type: Research article

    Leptospira interrogans is a pathogenic, spirochetal bacterium that is responsible for leptospirosis, an emerging worldwide zoonosis. Leptospires colonize the renal proximal tubules and chronically infect the kidn...

    Authors: Takayoshi Yamaguchi, Naomi Higa, Nobuhiko Okura, Arina Matsumoto, Idam Hermawan, Tetsu Yamashiro, Toshihiko Suzuki and Claudia Toma

    Citation: BMC Microbiology 2018 18:64

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  49. Content type: Research article

    Galleria mellonella larvae were infected with conidia of Aspergillus fumigatus and the cellular and humoral immune responses of larvae to the pathogen were characterized as invasive aspergillosis developed.

    Authors: Gerard Sheehan, Gráinne Clarke and Kevin Kavanagh

    Citation: BMC Microbiology 2018 18:63

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  50. Content type: Methodology article

    The development of vaccines and evaluation of novel treatment strategies for invasive group A streptococcal (iGAS) disease requires suitable models of human infection that can be monitored longitudinally and a...

    Authors: L. E. Lamb, X. Zhi, F. Alam, M. Pyzio, C. L. Scudamore, S. Wiles and S. Sriskandan

    Citation: BMC Microbiology 2018 18:60

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