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Microbe-host interactions and microbial pathogenicity

Section edited by David Nelson

This section aims to publish studies looking at all aspects of microbe-host interactions and pathogenicity including pathogenic mechanisms, virulence factors, host invasion, immune evasion, host defence, immunity, immunology and symbiotic interactions.

Page 1 of 7

  1. Content type: Research article

    Aspergillus fumigatus is a ubiquitous saprotrophic fungus and an opportunistic pathogen of humans and animals. Humans and animals can inhale hundreds of A. fumigatus spores daily. Normally this is harmless for hu...

    Authors: Ivan D. Valdes, Joris van den Berg, Annika Haagsman, Natalia Escobar, Jacques F. Meis, Ferry Hagen, Pieter Jan Haas, Jos Houbraken, Han A. B. Wösten and Hans de Cock

    Citation: BMC Microbiology 2018 18:118

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  2. Content type: Research article

    Quorum sensing (QS) is a cell-to cell communication system that bacteria use to synchronize activities as a group. LitR, the master regulator of QS in Aliivibrio salmonicida, was recently shown to regulate activi...

    Authors: Miriam Khider, Nils Peder Willassen and Hilde Hansen

    Citation: BMC Microbiology 2018 18:116

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  3. Content type: Research article

    Asthma, one of the most common chronic respiratory disorders, is associated with the hyper-activation of the T-cell subset of adaptive immunity. The gut microbiota may be involved in the development of asthma ...

    Authors: Qi Wang, Fei Li, Bishan Liang, Yuhu Liang, Sijie Chen, Xiaodong Mo, Yanmei Ju, Hui Zhao, Huijue Jia, Timothy D. Spector, Hailiang Xie and Ruijin Guo

    Citation: BMC Microbiology 2018 18:114

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  4. Content type: Research article

    Dexamethasone (Dex), an artificially synthetic cortisol substitute, is commonly used as an anti-inflammatory drug, and is also employed to mimic the stress state experimentally. It is well known that chronic s...

    Authors: Canfeng Hua, Yali Geng, Qu Chen, Liqiong Niu, Liuping Cai, Shiyu Tao, Yingdong Ni and Ruqian Zhao

    Citation: BMC Microbiology 2018 18:112

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  5. Content type: Research article

    Campylobacter jejuni is one of the most common bacterial causes of food-borne enteritis worldwide. Chemotaxis in C. jejuni is known to be critical for the successful colonization of the host and key for the adapt...

    Authors: Anastasia-Lisa Lübke, Sabrina Minatelli, Thomas Riedel, Raimond Lugert, Isabel Schober, Cathrin Spröer, Jörg Overmann, Uwe Groß, Andreas E. Zautner and Wolfgang Bohne

    Citation: BMC Microbiology 2018 18:111

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  6. Content type: Research article

    The stability of intestinal microorganisms plays an important role in human health, as the intestines perform important functions in the human body. Staphylococcus aureus is a Gram-positive, facultative anaerobic...

    Authors: Dayong Ren, Shengjie Gong, Jingyan Shu, Jianwei Zhu, Hongyan Liu and Ping Chen

    Citation: BMC Microbiology 2018 18:109

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  7. Content type: Research article

    Corynebacterium diphtheriae is the etiologic agent of diphtheria and different systemic infections. The bacterium has been classically described as an extracellular pathogen. However, a number of studies revealed...

    Authors: Dulanthi Weerasekera, Franziska Stengel, Heinrich Sticht, Ana Luíza de Mattos Guaraldi, Andreas Burkovski and Camila Azevedo Antunes

    Citation: BMC Microbiology 2018 18:106

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  8. Content type: Research article

    The Gram-negative phytopathogenic bacterium Xanthomonas campestris pv. campestris recruits the hrp/T3SS system to inject pathogenicity effector proteins into host cells and uses the rpf/DSF cell-cell signaling sy...

    Authors: Bo-Le Jiang, Guo-Feng Jiang, Wei Liu, Li-Chao Yang, Li-Yan Yang, Lin Wang, Xiao-Hong Hang and Ji-Liang Tang

    Citation: BMC Microbiology 2018 18:103

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  9. Content type: Research article

    Phage therapy is the therapeutic use of bacteriophages to treat highly drug resistant bacterial infections. The current surge in bacteriophage therapy is motivated mainly because of the emergence of antibiotic...

    Authors: Prasanth Manohar, Ramesh Nachimuthu and Bruno S. Lopes

    Citation: BMC Microbiology 2018 18:97

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  10. Content type: Research article

    Colorectal cancer (CRC) is a common malignant gastrointestinal tumor. In China, CRC is the 5th most commonly diagnosed cancer. The vast majority of CRC cases are sporadic and evolve with the adenoma-carcinoma ...

    Authors: Yongzhen Zhang, Xin Yu, Enda Yu, Na Wang, Quancai Cai, Qun Shuai, Feihu Yan, Lufang Jiang, Hexing Wang, Jianxiang Liu, Yue Chen, Zhaoshen Li and Qingwu Jiang

    Citation: BMC Microbiology 2018 18:92

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  11. Content type: Research article

    Apple canker is a devastating branch disease caused by Valsa mali (Vm). The endophytic actinomycete Saccharothrix yanglingensis Hhs.015 (Sy Hhs.015) can effectively inhibit the growth of Vm. To reveal the mechani...

    Authors: Cong Liu, Dongying Fan, Yanfang Li, Yue Chen, Lili Huang and Xia Yan

    Citation: BMC Microbiology 2018 18:90

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  12. Content type: Research article

    Since recognizing the interaction between Brucella and host cells is crucial to the elucidation of the infectious process, Brucella researches have prioritized the investigation of genes related to pathogenicity....

    Authors: Myunghwan Jung, Soojin Shim, Young Bin Im, Woo Bin Park and Han Sang Yoo

    Citation: BMC Microbiology 2018 18:82

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  13. Content type: Research article

    Bovine tuberculosis (bTB) caused by Mycobacterium bovis is the most serious endemic disease affecting livestock in the UK. The European badger (Meles meles) is the most important wildlife reservoir of bTB transmi...

    Authors: Anna Stedman, Carlos Maluquer de Motes, Sandrine Lesellier, Deanna Dalley, Mark Chambers and Jorge Gutierrez-Merino

    Citation: BMC Microbiology 2018 18:74

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  15. Content type: Research article

    Leptospira interrogans is a pathogenic, spirochetal bacterium that is responsible for leptospirosis, an emerging worldwide zoonosis. Leptospires colonize the renal proximal tubules and chronically infect the kidn...

    Authors: Takayoshi Yamaguchi, Naomi Higa, Nobuhiko Okura, Arina Matsumoto, Idam Hermawan, Tetsu Yamashiro, Toshihiko Suzuki and Claudia Toma

    Citation: BMC Microbiology 2018 18:64

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  16. Content type: Research article

    Galleria mellonella larvae were infected with conidia of Aspergillus fumigatus and the cellular and humoral immune responses of larvae to the pathogen were characterized as invasive aspergillosis developed.

    Authors: Gerard Sheehan, Gráinne Clarke and Kevin Kavanagh

    Citation: BMC Microbiology 2018 18:63

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  17. Content type: Methodology article

    The development of vaccines and evaluation of novel treatment strategies for invasive group A streptococcal (iGAS) disease requires suitable models of human infection that can be monitored longitudinally and a...

    Authors: L. E. Lamb, X. Zhi, F. Alam, M. Pyzio, C. L. Scudamore, S. Wiles and S. Sriskandan

    Citation: BMC Microbiology 2018 18:60

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  18. Content type: Research article

    Airway epithelium is the primary target for pathogens. It functions not only as a mechanical barrier, but also as an important sentinel of the innate immune system. However, the interactions and processes betw...

    Authors: Yinghua Li, Guangnan Liu, Jianquan Zhang, Xiaoning Zhong and Zhiyi He

    Citation: BMC Microbiology 2018 18:58

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  19. Content type: Research article

    Avian β-defensins (AvBD) are cationic antimicrobial peptides (CAMP) with broad-spectrum antimicrobial activity, chemotactic property, and low host cytotoxicity. However, their bactericidal activity is greatly ...

    Authors: Ming Yang, Chunye Zhang, Michael Z. Zhang and Shuping Zhang

    Citation: BMC Microbiology 2018 18:54

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  20. Content type: Database

    Recent research has provided fascinating indications and evidence that the host health is linked to its microbial inhabitants. Due to the development of high-throughput sequencing technologies, more and more d...

    Authors: Yorick Janssens, Joachim Nielandt, Antoon Bronselaer, Nathan Debunne, Frederick Verbeke, Evelien Wynendaele, Filip Van Immerseel, Yves-Paul Vandewynckel, Guy De Tré and Bart De Spiegeleer

    Citation: BMC Microbiology 2018 18:50

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  21. Content type: Research article

    Mice are a natural host for Rodentibacter (R.) pneumotropicus. Despite specific monitoring, it is still one of the most important infectious agents in laboratory animals. The objective of this study was to determ...

    Authors: Juliane Fornefett, Jaqueline Krause, Kristin Klose, Felix Fingas, Rayk Hassert, Laurentiu Benga, Thomas Grunwald, Uwe Müller, Wieland Schrödl and Christoph Georg Baums

    Citation: BMC Microbiology 2018 18:45

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  22. Content type: Research article

    Brucella causes a chronic and debilitating infection that leads to great economic losses and a public health burden. In this study, we demonstrated the brucellacidal effect of heat shock mediated by the induction...

    Authors: Huynh Tan Hop, Lauren Togonon Arayan, Alisha Wehdnesday Bernardo Reyes, Tran Xuan Ngoc Huy, Won Gi Min, Hu Jang Lee, Man Hee Rhee, Hong Hee Chang and Suk Kim

    Citation: BMC Microbiology 2018 18:44

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  23. Content type: Methodology Article

    Global warming has triggered an increase in the prevalence and severity of coral disease, yet little is known about coral/pathogen interactions in the early stages of infection. The point of entry of the patho...

    Authors: E. Gibbin, A. Gavish, I. Domart-Coulon, E. Kramarsky-Winter, O. Shapiro, A. Meibom and A. Vardi

    Citation: BMC Microbiology 2018 18:39

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  24. Content type: Research

    Staphylococcus aureus cell wall anchored Serine Aspartate repeat containing protein D (SdrD) is a member of the microbial surface component recognising adhesive matrix molecules (MSCRAMMs). It is involved in the ...

    Authors: Clement Ajayi, Espen Åberg, Fatemeh Askarian, Johanna U. E. Sollid, Mona Johannessen and Anne-Merethe Hanssen

    Citation: BMC Microbiology 2018 18:34

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  25. Content type: Research article

    Porcine tonsils are lympho-epithelial tissues, colonized by numerous bacteria and viruses, that act as a reservoir for both host-specific pathogens and zoonotic pathogens with a high potential of transmission ...

    Authors: Luis Carlos Pena Cortes, Rhiannon M. LeVeque, Julie Funk, Terence L. Marsh and Martha H. Mulks

    Citation: BMC Microbiology 2018 18:35

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  26. Content type: Research article

    We and others have previously shown that alterations in the mammalian gut microbiome are associated with diet, notably early life exposure to a maternal high fat diet (HFD). Here, we aimed to further these stu...

    Authors: Ryan M. Pace, Amanda L. Prince, Jun Ma, Benjamin D. W. Belfort, Alexia S. Harvey, Min Hu, Karalee Baquero, Peter Blundell, Diana Takahashi, Tyler Dean, Paul Kievit, Elinor L. Sullivan, Jacob E. Friedman, Kevin Grove and Kjersti M. Aagaard

    Citation: BMC Microbiology 2018 18:28

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  27. Content type: Research article

    Porphyromonas gingivalis (P. gingivalis), one of the main pathogenic bacteria involved in periodontitis, induces the expression of intercellular adhesion molecule − 1 (ICAM-1) and monocyte-endothelial cell adhesi...

    Authors: Wanyue Xu, Yaping Pan, Qiufang Xu, Yun Wu, Jiayu Pan, Jingya Hou, Li Lin, Xiaolin Tang, Chen Li, Jingbo Liu and Dongmei Zhang

    Citation: BMC Microbiology 2018 18:16

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  28. Content type: Research article

    The intracellular bacterial pathogen Legionella pneumophila proliferates in human alveolar macrophages, resulting in a severe pneumonia termed Legionnaires’ disease. Throughout the course of infection, L. pneumop...

    Authors: Xiaobo Yu, Rebecca R. Noll, Barbara P. Romero Dueñas, Samual C. Allgood, Kristi Barker, Jeffrey L. Caplan, Matthias P. Machner, Joshua LaBaer, Ji Qiu and M. Ramona Neunuebel

    Citation: BMC Microbiology 2018 18:5

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  29. Content type: Research article

    Ustilago esculenta, a pathogenic basidiomycete fungus, infects Zizania latifolia to form edible galls named Jiaobai in China. The distinct growth conditions of U. esculenta induced Z. ...

    Authors: Yafen Zhang, Qianchao Cao, Peng Hu, Haifeng Cui, Xiaoping Yu and Zihong Ye

    Citation: BMC Microbiology 2017 17:228

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  30. Content type: Research article

    Helicobacter pylori (H. pylori) is a Gram-negative, microaerophilic bacterium that is recognized as a major cause of chronic gastritis, peptic ulcers, and gastric cancer. Comparable to...

    Authors: Kristy Leker, Ivonne Lozano-Pope, Keya Bandyopadhyay, Biswa P. Choudhury and Marygorret Obonyo

    Citation: BMC Microbiology 2017 17:226

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  31. Content type: Research article

    Although plants produce many secondary metabolites, currently none of these are commercial antibiotics. Insects feeding on specific plants can harbour bacterial strains resistant to known antibiotics suggestin...

    Authors: Katarzyna Ignasiak and Anthony Maxwell

    Citation: BMC Microbiology 2017 17:223

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  32. Content type: Research article

    Vibrio anguillarum is an extracellular bacterial pathogen that is a causative agent of vibriosis in finfish and crustaceans with mortality rates ranging from 30% to 100%. Mutations in ...

    Authors: Xiangyu Mou, Edward J. Spinard, Shelby L. Hillman and David R. Nelson

    Citation: BMC Microbiology 2017 17:217

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  33. Content type: Research article

    During infection, inflammation is partially driven by the release of mediators which facilitate intercellular communication. Amongst these mediators are small membrane vesicles (MVs) that can be released by bo...

    Authors: Charlotte Volgers, Birke J. Benedikter, Gert E. Grauls, Paul H. M. Savelkoul and Frank R. M. Stassen

    Citation: BMC Microbiology 2017 17:216

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  34. Content type: Research article

    Streptococcus gallolyticus subsp. gallolyticus (S. gallolyticus) is the causative pathogen in up to 20% of streptococcal-induced infective endocarditis (IE) cases. However, the underly...

    Authors: Imke Grimm, Melanie Weinstock, Ingvild Birschmann, Jens Dreier, Cornelius Knabbe and Tanja Vollmer

    Citation: BMC Microbiology 2017 17:210

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  35. Content type: Research article

    Rice (Oryza sativa L. ssp. indica) seeds as plant microbiome present both an opportunity and a challenge to colonizing bacterial community living in close association with plants. Nevertheless, the roles and acti...

    Authors: Denver I. Walitang, Kiyoon Kim, Munusamy Madhaiyan, Young Kee Kim, Yeongyeong Kang and Tongmin Sa

    Citation: BMC Microbiology 2017 17:209

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  36. Content type: Research article

    Breast milk is a rich nutrient with a temporally dynamic nature. In particular, numerous alterations in the nutritional, immunological and microbiological content occur during the transition from colostrum to ...

    Authors: Marco Toscano, Roberta De Grandi, Diego Giampietro Peroni, Enzo Grossi, Valentina Facchin, Pasquale Comberiati and Lorenzo Drago

    Citation: BMC Microbiology 2017 17:205

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  37. Content type: Research article

    Outbreaks of infections caused by rapidly growing mycobacteria have been reported worldwide generally associated with medical procedures. Mycobacterium abscessus subsp. massiliense CRM0019 was obtained during an ...

    Authors: Giovanni Monteiro Ribeiro, Cristianne Kayoko Matsumoto, Fernando Real, Daniela Teixeira, Rafael Silva Duarte, Renato Arruda Mortara, Sylvia Cardoso Leão and Cristiane de Souza Carvalho-Wodarz

    Citation: BMC Microbiology 2017 17:195

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  38. Content type: Research article

    The complexity of the pathogenic mechanism underlying the host immune response to Actinobacillus pleuropneumonia (App) makes the use of preventive measures difficult, and a more global view of the host-pathogen i...

    Authors: Ping Li, Zhiwen Xu, Xiangang Sun, Yue Yin, Yi Fan, Jun Zhao, Xiyu Mao, Jianbo Huang, Fan Yang and Ling Zhu

    Citation: BMC Microbiology 2017 17:193

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  39. Content type: Research article

    Non-structural protein 1 (NS1) is a multifunctional protein and a crucial regulatory factor in the replication and pathogenesis of avian influenza virus (AIV). Studies have shown that NS1 can interact with a v...

    Authors: Yong Ma, Jiashan Sun, Linlin Gu, Hongmei Bao, Yuhui Zhao, Lin Shi, Wei Yao, Guobin Tian, Xiurong Wang and Hualan Chen

    Citation: BMC Microbiology 2017 17:191

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  40. Content type: Research article

    The bronchial epithelium serves as the first defendant line of host against respiratory inhaled pathogens, mainly through releasing chemokines (e.g. interleukin-8 (IL-8), interferon-induced protein 10 (IP-10) ...

    Authors: Jiaqiong Zou, Long Zhou, Chunlan Hu, Peng Jing, Xiaolan Guo, Sulan Liu, Yan Lei, Shangyu Yang, Jiankang Deng and Hong Zhang

    Citation: BMC Microbiology 2017 17:187

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  41. Content type: Research article

    Intracellular bacterium, Mycobacterium tuberculosis (M. tb), infects specifically macrophages as host cells. IRAK-M, a member of IRAK family, is a negative regulator in TLR signaling and specifically expresses in...

    Authors: Pei Shen, Quan Li, Jilei Ma, Maopeng Tian, Fei Hong, Xinjie Zhai, Jianrong Li, Hanju Huang and Chunwei Shi

    Citation: BMC Microbiology 2017 17:185

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  42. Content type: Research article

    Penicillium marneffei (P. marneffei) is a thermally dimorphic fungus pathogen that causes fatal infection. Alveolar macrophages are innate immune cells that have critical roles in prot...

    Authors: Xiaoying Dai, Congzheng Mao, Xiuwan Lan, Huan Chen, Meihua Li, Jing Bai, Jingmin Deng, Qiuli Liang, Jianquan Zhang, Xiaoning Zhong, Yi Liang, Jiangtao Fan, Honglin Luo and Zhiyi He

    Citation: BMC Microbiology 2017 17:177

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  43. Content type: Research article

    Probiotics are increasingly applied to prevent and treat a range of infectious, immune related and gastrointestinal diseases. Despite this, the mechanisms behind the putative effects of probiotics are poorly u...

    Authors: Martin Frederik Laursen, Rikke Pilmann Laursen, Anni Larnkjær, Kim F. Michaelsen, Martin Iain Bahl and Tine Rask Licht

    Citation: BMC Microbiology 2017 17:175

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  44. Content type: Research article

    Bacterial blight of rice caused by Xanthomonas oryzae pv. oryzae (Xoo) is one of the most important crop diseases in the world. More insights into the mechanistic regulation of bacterial pathogenesis will help us...

    Authors: Chao Yu, Huamin Chen, Fang Tian, Fenghuan Yang and Chenyang He

    Citation: BMC Microbiology 2017 17:171

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  45. Content type: Research article

    The World Health Organization has categorized plague as a re-emerging disease and the potential for Yersinia pestis to also be used as a bioweapon makes the identification of new drug targets against this pathoge...

    Authors: Nicola J. Senior, Kalesh Sasidharan, Richard J. Saint, Andrew E. Scott, Mitali Sarkar-Tyson, Philip M. Ireland, Helen L Bullifent, Z. Rong Yang, Karen Moore, Petra C. F. Oyston, Timothy P. Atkins, Helen S. Atkins, Orkun S. Soyer and Richard W. Titball

    Citation: BMC Microbiology 2017 17:163

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  46. Content type: Research article

    Group B Streptococcus (GBS) is a major cause of invasive disease especially in neonates. In GBS three structurally distinct pilus polymers have been identified as important virulence factors and promising vacc...

    Authors: Maddalena Lazzarin, Rong Mu, Monica Fabbrini, Claudia Ghezzo, C. Daniela Rinaudo, Kelly S. Doran and Immaculada Margarit

    Citation: BMC Microbiology 2017 17:148

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  48. Content type: Research article

    The objective of this study was to better understand the effects of soluble factors from biofilm of single- and mixed-species Candida albicans (C. albicans) and methicillin-sensitive Staphylococcus aureus (MSSA) ...

    Authors: Kassia de Carvalho Dias, Paula Aboud Barbugli, Fernanda de Patto, Virginia Barreto Lordello, Letícia de Aquino Penteado, Alexandra Ivo Medeiros and Carlos Eduardo Vergani

    Citation: BMC Microbiology 2017 17:146

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  49. Content type: Research article

    The phytopathogenic Xanthomonas campestris pv.campestris is a gram-negative bacterium and the causal agent of black-rot disease of cruciferous crops. Many gram-negative bacteria possess a family of proteins, call...

    Authors: Lei Chen, Mingpeng Wang, Li Huang, Zhaojie Zhang, Fanghua Liu and Guangtao Lu

    Citation: BMC Microbiology 2017 17:142

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