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Clinical microbiology and vaccines

Section edited by Igor Mokrousov 

This section aims to publish studies looking at all aspects of clinical microbiology, including virology, epidemiology, antimicrobial resistance, vaccines and immune responses.

Page 1 of 7

  1. Despite vaccination programs, Streptococcus pneumoniae remains among the main microorganisms involved in bacterial pneumonia, notably in terms of severity. The prognosis of pneumococcal infections is conditioned ...

    Authors: Cyrille H. Haddar, Johan Joly, Anne Carricajo, Paul O. Verhoeven, Florence Grattard, Olivier Mory, Evelyne Begaud, Yves Germani, Aymeric Cantais and Bruno Pozzetto

    Citation: BMC Microbiology 2020 20:79

    Content type: Research article

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  2. Different diagnostic methods have been used for the laboratory confirmation of leptospirosis. Molecular diagnostic techniques are not only faster and more sensitive than culture analysis, but can also detect a Le...

    Authors: Daša Podgoršek, Eva Ružić-Sabljić, Mateja Logar, Andrea Pavlović, Tatjana Remec, Zvonko Baklan, Emil Pal and Tjaša Cerar

    Citation: BMC Microbiology 2020 20:59

    Content type: Research article

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  3. The treatment of Enterobacteriaceae family including diarrheagenic E. coli (DEC) has been increasingly complicated due to the emergence of resistant strains. Here we report on the phenotypic resistance profiles a...

    Authors: Nahla O. Eltai, Asmaa A. Al Thani, Sara H. Al Hadidi, Khalid Al Ansari and Hadi M. Yassine

    Citation: BMC Microbiology 2020 20:54

    Content type: Research article

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  4. The dogma that urine is sterile in healthy individuals has been overturned by recent studies applying molecular-based methods. Mounting evidences indicate that dysbiosis of the urinary microbiota is associated...

    Authors: Jing Xie, Jian-sheng Huang, Xiang-jiang Huang, Jun-ming Peng, Zhou Yu, Ye-qing Yuan, Ke-feng Xiao and Ji-nan Guo

    Citation: BMC Microbiology 2020 20:41

    Content type: Research article

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  5. Klebsiella pneumoniae is considered the most clinically relevant species of Enterobacteriaceae, known to cause severe infections including liver abscesses. To the best of our knowledge, a large proportion of iron...

    Authors: Tao Chen, Guofeng Dong, Siqin Zhang, Xiucai Zhang, Yajie Zhao, Jianming Cao, Tieli Zhou and Qing Wu

    Citation: BMC Microbiology 2020 20:36

    Content type: Research article

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  6. Bergeyella cardium infection is becoming increasingly prevalent in patients with infective endocarditis, suggesting its significance in disease pathogenesis. However, few studies have fully characterized this spe...

    Authors: Hongwei Pan, Wei Li, Enhua Sun and Yi Zhang

    Citation: BMC Microbiology 2020 20:32

    Content type: Research article

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  7. Some strains of Bacteroides fragilis species are associated with diarrhea as a result of enterotoxin production (bft or fragilysin). Fragilysin is activated by C11 protease (fpn) and together with C10 protease (b...

    Authors: Wafaa Jamal, Fatima Bibi Khodakhast, Ameerah AlAzmi, Jόzsef Sόki, Ghayda AlHashem and Vincent O. Rotimi

    Citation: BMC Microbiology 2020 20:14

    Content type: Research article

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  8. The exosporium of the anthrax-causing Bacillus anthracis endospores display a tetrasaccharide composed of three rhamnose residues and an unusual sugar termed anthrose. Anthrose is a proposed potential target for ...

    Authors: Diansy Zincke, Michael H. Norris, Berzhan Kurmanov, Ted L. Hadfield and Jason K. Blackburn

    Citation: BMC Microbiology 2020 20:6

    Content type: Methodology article

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  9. Antimicrobial combinations have been proven as a promising approach in the confrontation with multi-drug resistant bacterial pathogens. In the present study, we identify and characterize a synergistic interact...

    Authors: Vuong Van Hung Le, Catrina Olivera, Julian Spagnuolo, Ieuan G. Davies and Jasna Rakonjac

    Citation: BMC Microbiology 2020 20:5

    Content type: Research article

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  10. Trueperella pyogenes is one of the most clinically imperative bacteria responsible for severe cases of mastitis and metritis, particularly in postpartum dairy cows. The bacterium has emergence of antibiotic resis...

    Authors: Mobin Rezanejad, Sepideh Karimi and Hassan Momtaz

    Citation: BMC Microbiology 2019 19:305

    Content type: Research article

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  11. Pneumococcus is exposed to a variety of temperature and oxygen levels in the upper respiratory tract and as it invades the lung, tissues, and blood. We sought to determine the effect of environmental variabili...

    Authors: Adrienn Tóthpál, Katherine Desobry, Shreyas S. Joshi, Anne L. Wyllie and Daniel M. Weinberger

    Citation: BMC Microbiology 2019 19:304

    Content type: Research article

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  12. Treatment of P. aeruginosa wound infection is challenging due to its inherent and acquired resistance to many conventional antibiotics. Cationic antimicrobial peptides (CAMPs) with distinct modes of antimicrobial...

    Authors: Ming Yang, Chunye Zhang, Sarah A. Hansen, William J. Mitchell, Michael Z. Zhang and Shuping Zhang

    Citation: BMC Microbiology 2019 19:293

    Content type: Research article

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  13. Human brucellosis has become a severe public health problem in China’s Guangxi Province, and there has been higher prevalence of brucellosis in this region after 2010. Both multiple locus variable-number tande...

    Authors: Zhi-guo Liu, Miao Wang, Hong-yan Zhao, Dong-ri Piao, Hai Jiang and Zhen-jun Li

    Citation: BMC Microbiology 2019 19:292

    Content type: Research article

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  14. Pseudomonas aeruginosa is a nosocomial pathogen that causes severe infections in immunocompromised patients. Biofilm plays a significant role in the resistance of this bacterium and complicates the treatment of i...

    Authors: Maryam Banar, Mohammad Emaneini, Reza Beigverdi, Rima Fanaei Pirlar, Narges Node Farahani, Willem B. van Leeuwen and Fereshteh Jabalameli

    Citation: BMC Microbiology 2019 19:291

    Content type: Research article

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  15. Blood stream infections (BSIs) are a major cause of morbidity and mortality. The time from taking blood cultures to obtain results of antibiotic sensitivity can be up to five days which impacts patient care. T...

    Authors: Vanesa Anton-Vazquez, Samuel Adjepong, Cristina Suarez and Timothy Planche

    Citation: BMC Microbiology 2019 19:268

    Content type: Research article

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  16. The application of matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) mass spectrometry (MS) to microbial identification has allowed the development of rapid methods for identification of m...

    Authors: Walter Florio, Susanna Cappellini, Cesira Giordano, Alessandra Vecchione, Emilia Ghelardi and Antonella Lupetti

    Citation: BMC Microbiology 2019 19:267

    Content type: Methodology article

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  17. The increase and spread of virulent-outbreak associated, methicillin and vancomycin resistant (MRSA/VRSA) Staphylococcus aureus require a better understanding of the resistance and virulence patterns of circulati...

    Authors: Cecilia Kyany’a, Justin Nyasinga, Daniel Matano, Valerie Oundo, Simon Wacira, Willie Sang and Lillian Musila

    Citation: BMC Microbiology 2019 19:245

    Content type: Research article

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  18. In light of rampant childhood diarrhoea, this study investigated bacterial pathogens from human and non-human sources in an urban informal settlement.

    Authors: John Bosco Kalule, Anthony M. Smith, Mjikisile Vulindhlu, Nomsa P. Tau, Mark P. Nicol, Karen H. Keddy and Lourens Robberts

    Citation: BMC Microbiology 2019 19:244

    Content type: Research article

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  19. Mycoplasma hyorhinis (Mhr) is the etiologic agent of lameness and polyserositis in swine. P37 is a membrane protein of Mhr that may be an important immunogen and is a potential target for diagnostic development. ...

    Authors: Hongzhen Zhu, Yanwu Wei, Liping Huang, Dan Liu, Yongxing Xie, Deli Xia, Haiqiao Bian, Li Feng and Changming Liu

    Citation: BMC Microbiology 2019 19:242

    Content type: Research article

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  20. Detection of ceftazidime/avibactam (CAZ/AVI) antibacterial activity is absolutely vital with the rapid growth of carbapenem resistant Enterobacteriaceae (CRE). But now, there is no available automated antimicrobi...

    Authors: Xianggui Yang, Dan Wang, Qin Zhou, Fang Nie, Hongfei Du, Xueli Pang, Yingzi Fan, Tingting Bai and Ying Xu

    Citation: BMC Microbiology 2019 19:240

    Content type: Research article

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  21. To evaluate the antibiotic resistance patterns of uropathogens isolated from adult women with acute community-acquired (CA) uncomplicated cystitis.

    Authors: Jamaan Al-Zahrani, Khaled Al Dossari, Ahmed H. Gabr, Abul-fotouh Ahmed, Saad Abdulrahman Al Shahrani and Sameer Al-Ghamdi

    Citation: BMC Microbiology 2019 19:237

    Content type: Research article

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  22. Porcine enzootic pneumonia is a worldwide problem in swine production. The infected host demonstrates a respiratory disease whose etiologic agent is Mycoplasma hyopneumoniae (Mhp). A total of 266 lung samples wit...

    Authors: Viviane Sisdelli Assao, Thalita Moreira Scatamburlo, Elaine Nery Araujo, Marcus Rebouças Santos, Carlos Eduardo Real Pereira, Roberto Maurício Carvalho Guedes, Gustavo Costa Bressan, Juliana Lopes Rangel Fietto, Yung-Fu Chang, Maria Aparecida Scatamburlo Moreira and Abelardo Silva-Júnior

    Citation: BMC Microbiology 2019 19:234

    Content type: Research article

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    The Correction to this article has been published in BMC Microbiology 2019 19:258

  23. We aimed to determine the evolutionary pathways of rifampicin resistance in Staphylococcus aureus, and the impact of resistance mutations in the rpoB gene on fitness.

    Authors: Chong Wang, Renchi Fang, Beibei Zhou, Xuebin Tian, Xiucai Zhang, Xiangkuo Zheng, Siqin Zhang, Guofeng Dong, Jianming Cao and Tieli Zhou

    Citation: BMC Microbiology 2019 19:220

    Content type: Research article

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  24. Shiga toxin-producing Escherichia coli (STEC) are emerging foodborne pathogens that are public health concern. Cattle have been identified as the major STEC reservoir. In the present study, we investigated the pr...

    Authors: Ruyue Fan, Kun Shao, Xi Yang, Xiangning Bai, Shanshan Fu, Hui Sun, Yanmei Xu, Hong Wang, Qun Li, Bin Hu, Ji Zhang and Yanwen Xiong

    Citation: BMC Microbiology 2019 19:213

    Content type: Research article

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  25. Escherichia coli has found to be the predominant uropathogen (50–90%) in uncomplicated, community acquired urinary tract infection (UTI). Uropathogenic Escherichia coli (UPEC) express a multitude of virulence fac...

    Authors: Chhaya Shah, Ratna Baral, Bijay Bartaula and Lok Bahadur Shrestha

    Citation: BMC Microbiology 2019 19:204

    Content type: Research article

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  26. Salmonella has been considered as one of the most important foodborne pathogens that threatened breeding industry and public health. To investigate the prevalence and characterization of Salmonella isolated from ...

    Authors: Jie Yang, Zijing Ju, Yi Yang, Xiaonan Zhao, Zhiyu Jiang and Shuhong Sun

    Citation: BMC Microbiology 2019 19:202

    Content type: Research article

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  27. Candidatus Neoehrlichia mikurensis is an emerging tick-borne pathogen. It is widely distributed in Ixodes ricinus ticks in Europe, but knowledge of its distribution in Norway, where I. ricinus reaches its norther...

    Authors: Andrew Jenkins, Cecilie Raasok, Benedikte N. Pedersen, Kristine Jensen, Åshild Andreassen, Arnulf Soleng, Kristin Skarsfjord Edgar, Heidi Heggen Lindstedt, Vivian Kjelland, Snorre Stuen, Dag Hvidsten and Bjørn-Erik Kristiansen

    Citation: BMC Microbiology 2019 19:199

    Content type: Research article

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    The Correction to this article has been published in BMC Microbiology 2020 20:9

  28. The rise of methicillin-resistant Staphylococcus aureus (MRSA) is a global health concern. Paucity of data on MRSA carriage prevalence and diagnostic methods in resource-limited settings hampers efforts to define...

    Authors: A. Ayebare, L. M. Bebell, J. Bazira, S. Ttendo, V. Katawera, D. R. Bangsberg, M. J. Siedner, P. G. Firth and Y. Boum II

    Citation: BMC Microbiology 2019 19:194

    Content type: Research article

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  29. Human skin is an appropriate environment for the growth of different types of microbes that may inhabit the skin as commensal flora. This study aims at identifying the diversity of skin microbiota in healthy S...

    Authors: Ashwag Shami, Samiah Al-Mijalli, Pisut Pongchaikul, Ahmed Al-Barrag and Samah AbduRahim

    Citation: BMC Microbiology 2019 19:189

    Content type: Research article

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  30. Group B Streptococcus (GBS) is a leading cause of early-onset disease (EOD) and late-onset disease (LOD) in infants. We sought to investigate the antibiotic susceptibility profiles, resistance genes, virulence-re...

    Authors: Benqing Wu, Jinzhen Su, Li Li, Weiyuan Wu, Jingsong Wu, Yuemei Lu, Wenqing Li, Jin’e Cheng and Xunhong Liang

    Citation: BMC Microbiology 2019 19:185

    Content type: Research article

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  31. Early pathogen detection and identification are crucial for an effective and targeted antibiotic therapy in patients suffering from blood stream infection. Molecular diagnostic methods can accelerate pathogen ...

    Authors: Matthias Pilecky, Anita Schildberger, Ludwig Knabl, Dorothea Orth-Höller and Viktoria Weber

    Citation: BMC Microbiology 2019 19:180

    Content type: Methodology article

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  32. Clarithromycin-resistance is becoming a global health concern in the treatment of Helicobacter pylori (H. pylori). The mutant prevention concentration (MPC) represent the propensities of antimicrobial agents to s...

    Authors: Zi-Han Feng, Ling Fan, Jing Yang, Xing-Yue Huo, Yan Guo, Yi Zhang and Chun-Hui Lan

    Citation: BMC Microbiology 2019 19:176

    Content type: Research article

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  33. Food-producing animals, mainly poultry, have been associated with the maintenance and dissemination of antibiotic-resistant bacteria, such as plasmid-mediated AmpC (pAmpC)-producing Enterobacteriaceae, to huma...

    Authors: Vanessa L. Koga, Renato P. Maluta, Wanderley D. da Silveira, Renan A. Ribeiro, Mariangela Hungria, Eliana C. Vespero, Gerson Nakazato and Renata K. T. Kobayashi

    Citation: BMC Microbiology 2019 19:174

    Content type: Research article

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  34. Linezolid-resistant enterococci pose great challenges in clinical practice. The aim of this study is to study the mechanisms underlying the resistance and genetic environment of antimicrobial resistance gene o...

    Authors: Hongbin Chen, Xiaojuan Wang, Yuyao Yin, Shuguang Li, Yawei Zhang, Qi Wang and Hui Wang

    Citation: BMC Microbiology 2019 19:162

    Content type: Research article

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  35. Enterococcus species continues to be an important cause of hospital-acquired infection worldwide. This study was designed to determine the antibiotic resistance profiles, virulence genes and molecular characte...

    Authors: Azin Sattari-Maraji, Fereshteh Jabalameli, Narges Node Farahani, Reza Beigverdi and Mohammad Emaneini

    Citation: BMC Microbiology 2019 19:156

    Content type: Research article

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  36. The prevalence of antibiotic resistance is increasing, and multidrug-resistant Pseudomonas aeruginosa has been identified as a serious threat to human health. The production of β-lactamase is a key mechanism cont...

    Authors: Katherine Young, Ronald E. Painter, Susan L. Raghoobar, Nichelle N. Hairston, Fred Racine, Douglas Wisniewski, Carl J. Balibar, Artjohn Villafania, Rumin Zhang, Daniel F. Sahm, Timothy Blizzard, Nicholas Murgolo, Milton L. Hammond and Mary R. Motyl

    Citation: BMC Microbiology 2019 19:150

    Content type: Research article

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  37. Candidemia is an emerging hospital-acquired bloodstream infection (BSI). It is common among severely ill and immunocompromised patients. Even following appropriate therapy in candidemia, recent studies reveal ...

    Authors: Mahen Kothalawala, J. A. A. S. Jayaweera, Sinnapoo Arunan and Anuradha Jayathilake

    Citation: BMC Microbiology 2019 19:136

    Content type: Research article

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  38. Macrolides and lincosamides are two leading types of antibiotics commonly used in therapies. The study examines the differences in resistance to these antibiotics and their molecular bases in S. epidermidis as we...

    Authors: Magdalena Szemraj, Tomasz Czekaj, Jacek Kalisz and Eligia M. Szewczyk

    Citation: BMC Microbiology 2019 19:124

    Content type: Research article

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  39. Acinetobacter baumannii is a cosmopolitan bacterium that is frequently reported from hospitalized patients, especially those patients who admitted in the intensive care unit. Recently, multiplex real-time PCR has...

    Authors: Hossein Goudarzi, Elnaz Sadat Mirsamadi, Zohreh Ghalavand, Mojdeh Hakemi Vala, Hamed Mirjalali and Ali Hashemi

    Citation: BMC Microbiology 2019 19:122

    Content type: Research article

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  40. Shigella spp., facultative anaerobic bacilli of the family Enterobacteriaceae, are one of the most common causes of diarrheal diseases in human worldwide which have become a significant public health burden. So, ...

    Authors: Yang Wang, Qiuxia Ma, Ruie Hao, Qiuxiang Zhang, Suxia Yao, Jiting Han, Binzhi Ren, Ting Fan, Limin Chen, Xuebin Xu, Shaofu Qiu and Hongxia Yang

    Citation: BMC Microbiology 2019 19:116

    Content type: Research article

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  41. Although the most widely accepted mechanism of action for polymyxins is related to bacterial lysis via disruption, we hypothesized that this antimicrobial drug class could have other effects on Pseudomonas aerugi...

    Authors: Marlucy Rodrigues Lima, Gabriella Freitas Ferreira, Wallace Ribeiro Nunes Neto, Joveliane de Melo Monteiro, Áquila Rodrigues Costa Santos, Priscila Batista Tavares, Ângelo Márcio Leite Denadai, Maria Rosa Quaresma Bomfim, Vera Lúcia dos Santos, Sirlei Garcia Marques and Andrea de Souza Monteiro

    Citation: BMC Microbiology 2019 19:115

    Content type: Research article

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  42. Gut bacteria are an important component of the microbiota ecosystem in humans and other animals, and they play important roles in human health. The aim of this study was to investigate the relationship between...

    Authors: Wu Enqi, Zhao Huanhu, Wu Ritu, Xie Dan, Lin Han, Wang Baili, Shen Gangyi and Li Shuchun

    Citation: BMC Microbiology 2019 19:111

    Content type: Research article

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  43. Infection with Brucella melitensis (B. melitensis) is one of the most important causes of abortion in goats and sheep, and also causes severe systemic disease in exposed humans. In Ethiopia, based on seroepidemio...

    Authors: Muluken Tekle, Mengistu Legesse, Bedaso Mammo Edao, Gobena Ameni and Gezahegne Mamo

    Citation: BMC Microbiology 2019 19:108

    Content type: Research article

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  44. Staphylococcus aureus (S. aureus) with accessory gene regulator (agr) dysfunction occurs in health care settings. This study evaluated the prevalence and the molecular and drug resistance characteristics of S. au...

    Authors: Xin Yang, Fang Dong, Suyun Qian, Lijuan Wang, Yingchao Liu, Kaihu Yao, Wenqi Song, Jinghui Zhen, Wei Zhou, Hong Xu and Hongyan Zheng

    Citation: BMC Microbiology 2019 19:95

    Content type: Research article

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  45. Concern exists that frequent use of topically-applied fusidic acid (FA) and chlorhexidine (CHX) for canine pyoderma is driving clinically relevant resistance, despite rare description of FA and CHX genetic res...

    Authors: S-M Frosini, R. Bond, M. Rantala, T. Grönthal, S. C. Rankin, K. O’Shea, D. Timofte, V. Schmidt, J. Lindsay and A. Loeffler

    Citation: BMC Microbiology 2019 19:81

    Content type: Research article

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  46. Pythium insidiosum is a member of the oomycetes class of aquatic fungus-like microorganisms. It can infect humans and animals through skin wounds and the eyes, causing pythiosis, an infectious disease with high m...

    Authors: Kittiya Wittayapipath, Saline Laolit, Chavi Yenjai, Sirinart Chio-Srichan, Maitree Pakarasang, Ratree Tavichakorntrakool and Chularut Prariyachatigul

    Citation: BMC Microbiology 2019 19:78

    Content type: Research article

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  47. Phenotypic fluoroquinolone resistance was first reported in Western Kenya in 2009 and later in Coastal Kenya and Nairobi. Until recently gonococcal fluoroquinolone resistance mechanisms in Kenya had not been e...

    Authors: Mary Wandia Kivata, Margaret Mbuchi, Fredrick Lunyagi Eyase, Wallace Dimbuson Bulimo, Cecilia Katunge Kyanya, Valerie Oundo, Simon Wachira Muriithi, Ben Andagalu, Wilton Mwema Mbinda, Olusegun O. Soge, R. Scott McClelland, Willy Sang and James D. Mancuso

    Citation: BMC Microbiology 2019 19:76

    Content type: Research article

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  48. The potential of next-generation sequencing (NGS) for hypothesis-free pathogen diagnosis from (poly-)microbially contaminated, formalin-fixed, paraffin embedded tissue samples from patients with invasive funga...

    Authors: Hagen Frickmann, Carsten Künne, Ralf Matthias Hagen, Andreas Podbielski, Jana Normann, Sven Poppert, Mario Looso and Bernd Kreikemeyer

    Citation: BMC Microbiology 2019 19:75

    Content type: Research article

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