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Clinical microbiology and vaccines

Section edited by Igor Mokrousov 

This section aims to publish studies looking at all aspects of clinical microbiology, including virology, epidemiology, antimicrobial resistance, vaccines and immune responses.

Page 1 of 6

  1. Content type: Research article

    Linezolid-resistant enterococci pose great challenges in clinical practice. The aim of this study is to study the mechanisms underlying the resistance and genetic environment of antimicrobial resistance gene o...

    Authors: Hongbin Chen, Xiaojuan Wang, Yuyao Yin, Shuguang Li, Yawei Zhang, Qi Wang and Hui Wang

    Citation: BMC Microbiology 2019 19:162

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  2. Content type: Research article

    Enterococcus species continues to be an important cause of hospital-acquired infection worldwide. This study was designed to determine the antibiotic resistance profiles, virulence genes and molecular characte...

    Authors: Azin Sattari-Maraji, Fereshteh Jabalameli, Narges Node Farahani, Reza Beigverdi and Mohammad Emaneini

    Citation: BMC Microbiology 2019 19:156

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  3. Content type: Research article

    The prevalence of antibiotic resistance is increasing, and multidrug-resistant Pseudomonas aeruginosa has been identified as a serious threat to human health. The production of β-lactamase is a key mechanism cont...

    Authors: Katherine Young, Ronald E. Painter, Susan L. Raghoobar, Nichelle N. Hairston, Fred Racine, Douglas Wisniewski, Carl J. Balibar, Artjohn Villafania, Rumin Zhang, Daniel F. Sahm, Timothy Blizzard, Nicholas Murgolo, Milton L. Hammond and Mary R. Motyl

    Citation: BMC Microbiology 2019 19:150

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  4. Content type: Research article

    Candidemia is an emerging hospital-acquired bloodstream infection (BSI). It is common among severely ill and immunocompromised patients. Even following appropriate therapy in candidemia, recent studies reveal ...

    Authors: Mahen Kothalawala, J. A. A. S. Jayaweera, Sinnapoo Arunan and Anuradha Jayathilake

    Citation: BMC Microbiology 2019 19:136

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  5. Content type: Research article

    Macrolides and lincosamides are two leading types of antibiotics commonly used in therapies. The study examines the differences in resistance to these antibiotics and their molecular bases in S. epidermidis as we...

    Authors: Magdalena Szemraj, Tomasz Czekaj, Jacek Kalisz and Eligia M. Szewczyk

    Citation: BMC Microbiology 2019 19:124

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  6. Content type: Research article

    Acinetobacter baumannii is a cosmopolitan bacterium that is frequently reported from hospitalized patients, especially those patients who admitted in the intensive care unit. Recently, multiplex real-time PCR has...

    Authors: Hossein Goudarzi, Elnaz Sadat Mirsamadi, Zohreh Ghalavand, Mojdeh Hakemi Vala, Hamed Mirjalali and Ali Hashemi

    Citation: BMC Microbiology 2019 19:122

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  7. Content type: Research article

    Shigella spp., facultative anaerobic bacilli of the family Enterobacteriaceae, are one of the most common causes of diarrheal diseases in human worldwide which have become a significant public health burden. So, ...

    Authors: Yang Wang, Qiuxia Ma, Ruie Hao, Qiuxiang Zhang, Suxia Yao, Jiting Han, Binzhi Ren, Ting Fan, Limin Chen, Xuebin Xu, Shaofu Qiu and Hongxia Yang

    Citation: BMC Microbiology 2019 19:116

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  8. Content type: Research article

    Although the most widely accepted mechanism of action for polymyxins is related to bacterial lysis via disruption, we hypothesized that this antimicrobial drug class could have other effects on Pseudomonas aerugi...

    Authors: Marlucy Rodrigues Lima, Gabriella Freitas Ferreira, Wallace Ribeiro Nunes Neto, Joveliane de Melo Monteiro, Áquila Rodrigues Costa Santos, Priscila Batista Tavares, Ângelo Márcio Leite Denadai, Maria Rosa Quaresma Bomfim, Vera Lúcia dos Santos, Sirlei Garcia Marques and Andrea de Souza Monteiro

    Citation: BMC Microbiology 2019 19:115

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  9. Content type: Research article

    Gut bacteria are an important component of the microbiota ecosystem in humans and other animals, and they play important roles in human health. The aim of this study was to investigate the relationship between...

    Authors: Wu Enqi, Zhao Huanhu, Wu Ritu, Xie Dan, Lin Han, Wang Baili, Shen Gangyi and Li Shuchun

    Citation: BMC Microbiology 2019 19:111

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  10. Content type: Research article

    Infection with Brucella melitensis (B. melitensis) is one of the most important causes of abortion in goats and sheep, and also causes severe systemic disease in exposed humans. In Ethiopia, based on seroepidemio...

    Authors: Muluken Tekle, Mengistu Legesse, Bedaso Mammo Edao, Gobena Ameni and Gezahegne Mamo

    Citation: BMC Microbiology 2019 19:108

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  11. Content type: Research article

    Staphylococcus aureus (S. aureus) with accessory gene regulator (agr) dysfunction occurs in health care settings. This study evaluated the prevalence and the molecular and drug resistance characteristics of S. au...

    Authors: Xin Yang, Fang Dong, Suyun Qian, Lijuan Wang, Yingchao Liu, Kaihu Yao, Wenqi Song, Jinghui Zhen, Wei Zhou, Hong Xu and Hongyan Zheng

    Citation: BMC Microbiology 2019 19:95

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  12. Content type: Research article

    Concern exists that frequent use of topically-applied fusidic acid (FA) and chlorhexidine (CHX) for canine pyoderma is driving clinically relevant resistance, despite rare description of FA and CHX genetic res...

    Authors: S-M Frosini, R. Bond, M. Rantala, T. Grönthal, S. C. Rankin, K. O’Shea, D. Timofte, V. Schmidt, J. Lindsay and A. Loeffler

    Citation: BMC Microbiology 2019 19:81

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  13. Content type: Research article

    Pythium insidiosum is a member of the oomycetes class of aquatic fungus-like microorganisms. It can infect humans and animals through skin wounds and the eyes, causing pythiosis, an infectious disease with high m...

    Authors: Kittiya Wittayapipath, Saline Laolit, Chavi Yenjai, Sirinart Chio-Srichan, Maitree Pakarasang, Ratree Tavichakorntrakool and Chularut Prariyachatigul

    Citation: BMC Microbiology 2019 19:78

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  14. Content type: Research article

    Phenotypic fluoroquinolone resistance was first reported in Western Kenya in 2009 and later in Coastal Kenya and Nairobi. Until recently gonococcal fluoroquinolone resistance mechanisms in Kenya had not been e...

    Authors: Mary Wandia Kivata, Margaret Mbuchi, Fredrick Lunyagi Eyase, Wallace Dimbuson Bulimo, Cecilia Katunge Kyanya, Valerie Oundo, Simon Wachira Muriithi, Ben Andagalu, Wilton Mwema Mbinda, Olusegun O. Soge, R. Scott McClelland, Willy Sang and James D. Mancuso

    Citation: BMC Microbiology 2019 19:76

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  15. Content type: Research article

    The potential of next-generation sequencing (NGS) for hypothesis-free pathogen diagnosis from (poly-)microbially contaminated, formalin-fixed, paraffin embedded tissue samples from patients with invasive funga...

    Authors: Hagen Frickmann, Carsten Künne, Ralf Matthias Hagen, Andreas Podbielski, Jana Normann, Sven Poppert, Mario Looso and Bernd Kreikemeyer

    Citation: BMC Microbiology 2019 19:75

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  16. Content type: Research article

    Mycobacterium tuberculosis (Mtb) is an etiological agent of tuberculosis (TB). Tuberculosis is a mounting problem worldwide. The only available vaccine BCG protects the childhood but not adulthood form of TB. The...

    Authors: Gurpreet Kaur, Atul Munish Chander, Gurwinder Kaur, Sudeep Kumar Maurya, Sajid Nadeem, Rakesh Kochhar, Sanjay Kumar Bhadada, Javed N. Agrewala and Shanmugam Mayilraj

    Citation: BMC Microbiology 2019 19:64

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  17. Content type: Research article

    Nontuberculous mycobacteria (NTM) are ubiquitous in nature and recognized agents of opportunistic infection, which is often aggravated by their intrinsic resistance to antimicrobials, poorly defined therapeuti...

    Authors: Sónia Gonçalves Pereira, Susana Alarico, Igor Tiago, Diogo Reis, Daniela Nunes-Costa, Olga Cardoso, Ana Maranha and Nuno Empadinhas

    Citation: BMC Microbiology 2019 19:62

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  18. Content type: Research article

    Fluoroquinolone resistance and ESBL-production are concurrently found in a limited number of Salmonella serotypes. The present study was aimed to characterize fluoroquinolone-resistant and ESBL-producing Salmonel...

    Authors: Zhaojun Xu, Qifa Song, Chunhua Li and Yefei Zhan

    Citation: BMC Microbiology 2019 19:61

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  19. Content type: Research article

    The recent description of the first plasmid-mediated colistin-resistant gene mcr-1, conferring transferable and low-level resistance to colistin, raised concern about the need to implement a rapid and reliable sc...

    Authors: Lucie Bardet, Liliane Okdah, Stéphanie Le Page, Sophie Alexandra Baron and Jean-Marc Rolain

    Citation: BMC Microbiology 2019 19:60

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  20. Content type: Research article

    Extended-spectrum cephalosporin resistance (ESC-R) in Escherichia coli and Klebsiella pneumoniae is a healthcare threat; high gastrointestinal carriage rates are reported from South-east Asia. Colonisation preval...

    Authors: J. J. van Aartsen, C. E. Moore, C. M. Parry, P. Turner, N. Phot, S. Mao, K. Suy, T. Davies, A. Giess, A. E. Sheppard, T. E. A. Peto, N. P. J. Day, D. W. Crook, A. S. Walker and N. Stoesser

    Citation: BMC Microbiology 2019 19:59

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  21. Content type: Research article

    Necrotising enterocolitis (NEC) is a common cause of death in preterm infants and is closely linked to the gut microbiota. Spontaneous intestinal perforation (SIP) also occurs in preterm neonates, but results ...

    Authors: Christopher J. Stewart, Roxana Fatemizadeh, Pamela Parsons, Christopher A. Lamb, Deborah A. Shady, Joseph F. Petrosino and Amy B. Hair

    Citation: BMC Microbiology 2019 19:52

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  22. Content type: Research article

    Enterococcus hirae is considered a part of the normal intestinal biota of several domestic animals, including poultry. However, this species is also associated with infective endocarditis in chickens, a disease t...

    Authors: Beata Dolka, Agata Anna Cisek and Piotr Szeleszczuk

    Citation: BMC Microbiology 2019 19:48

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  23. Content type: Research article

    Pseudomonas aeruginosa Sequence Type 235 is a clone that possesses an extraordinary ability to acquire mobile genetic elements and has been associated with the spread of resistance genes, including genes that enc...

    Authors: Deisy Abril, Ricaurte Alejandro Marquez-Ortiz, Betsy Castro-Cardozo, José Ignacio Moncayo-Ortiz, Narda María Olarte Escobar, Zayda Lorena Corredor Rozo, Niradiz Reyes, Catalina Tovar, Héctor Fabio Sánchez, Jaime Castellanos, Yina Marcela Guaca-González, Carmen Elisa Llanos-Uribe, Natasha Vanegas Gómez and Javier Escobar-Pérez

    Citation: BMC Microbiology 2019 19:45

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  24. Content type: Research article

    Postoperative complications are of great relevance in daily clinical practice, and the gut microbiome might play an important role by preventing pathogens from crossing the intestinal barrier. The two aims of ...

    Authors: Felix C. F. Schmitt, Thorsten Brenner, Florian Uhle, Svenja Loesch, Thilo Hackert, Alexis Ulrich, Stefan Hofer, Alexander H. Dalpke, Markus A. Weigand and Sébastien Boutin

    Citation: BMC Microbiology 2019 19:42

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  25. Content type: Research article

    Interaction of spermatozoa and Chlamydiae spp. might contribute to reduced fertility in cattle. To proof this hypothesis, bovine semen was incubated with viable or heat inactivated Chlamydia (C.) abortus or psitt...

    Authors: Thomas Eckert, Sandra Goericke-Pesch, Carsten Heydel, Martin Bergmann, Johannes Kauffold, Klaus Failing and Axel Wehrend

    Citation: BMC Microbiology 2019 19:23

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  26. Content type: Research article

    The urinary tract is inhabited by a diversity of microorganisms, known as the genitourinary microbiota. Here, we investigated the association between the use of antimicrobial drugs and the composition of the g...

    Authors: M. Mulder, D. Radjabzadeh, R. J. Hassing, J. Heeringa, A. G. Uitterlinden, R. Kraaij, B. H. Stricker and A. Verbon

    Citation: BMC Microbiology 2019 19:9

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  27. Content type: Research article

    Pullorum disease, caused by Salmonella enterica serovar Pullorum (S. Pullorum), is one of the most important bacterial infections in the poultry industry in developing countries, including China. To examine the p...

    Authors: Xiaodong Guo, Honglin Wang, Yiluo Cheng, Wenting Zhang, Qingping Luo, Guoyuan Wen, Guijun Wang, Huabin Shao and Tengfei Zhang

    Citation: BMC Microbiology 2018 18:225

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  28. Content type: Research article

    For Yersinia pestis, Burkholderia pseudomallei, and Burkholderia mallei, conventional broth microdilution (BMD) is considered the gold standard for antimicrobial susceptibility testing (AST) and, depending on the...

    Authors: Heather P. McLaughlin and David Sue

    Citation: BMC Microbiology 2018 18:218

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  29. Content type: Research article

    Human granulocytic anaplasmosis (HGA) is a tick-borne disease caused by the etiologic agent Anaplasma phagocytophilum. HGA was designated a nationally notifiable disease in the United States in 1998. Currently th...

    Authors: Francy L. Crosby, Anna M. Lundgren, Carol Hoffman, David W. Pascual and Anthony F. Barbet

    Citation: BMC Microbiology 2018 18:217

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  30. Content type: Research article

    VanB-type vancomycin (VAN) resistance gene clusters confer VAN resistances on Enterococcus spp. over a wide range of MIC levels (MIC = 4–1000 mg/L). However, the epidemiology and the molecular characteristics of ...

    Authors: Yusuke Hashimoto, Jun Kurushima, Takahiro Nomura, Koichi Tanimoto, Kiyoko Tamai, Hideji Yanagisawa, Komei Shirabe, Yasuyoshi Ike and Haruyoshi Tomita

    Citation: BMC Microbiology 2018 18:213

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  31. Content type: Research article

    Mortality rates for patients with Staphylococcus aureus (S. aureus) infections have improved only modestly in recent decades and S. aureus infections remain a major clinical challenge This study investigated the ...

    Authors: Fan Zhang, Bing Bai, Guang-jian Xu, Zhi-wei Lin, Gui-qiu Li, Zhong Chen, Hang Cheng, Xiang Sun, Hong-yan Wang, Yan-wei Chen, Jin-xin Zheng, Qi-wen Deng and Zhi-jian Yu

    Citation: BMC Microbiology 2018 18:211

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  32. Content type: Research article

    USA300 methicillin-resistant Staphylococcus aureus (MRSA) is a community- and hospital-acquired pathogen that frequently causes infections but also can survive on the human body asymptomatically as a part of the ...

    Authors: Timothy D. Read, Robert A. Petit III, Zachary Yin, Tuyaa Montgomery, Moira C. McNulty and Michael Z. David

    Citation: BMC Microbiology 2018 18:206

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  33. Content type: Research article

    Typhoid fever remains a public health concern in developing countries especially among the poor who live in informal settlements devoid of proper sanitation and clean water supply. In addition antimicrobial re...

    Authors: Winnie C. Mutai, Anne W. T. Muigai, Peter Waiyaki and Samuel Kariuki

    Citation: BMC Microbiology 2018 18:187

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  34. Content type: Research article

    The emergence of carbapenem-resistant Klebsiella pneumoniae (CR-KP) has become a significant problem worldwide and also being a major threat to children and newborns. Here we report an outbreak of NDM-1-producing...

    Authors: Xu Huang, Xiangjun Cheng, Pengfei Sun, Chenjie Tang, Fang Ni and Genyan Liu

    Citation: BMC Microbiology 2018 18:186

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  35. Content type: Research article

    Rapid detection of sources and transmission routes by molecular methods provides key data for risk management of methicillin-resistant Staphylococcus aureus-induced infections acquired in both the community and h...

    Authors: Tülin Güven Gökmen, Yıldız Kalayci, Akgün Yaman and Fatih Köksal

    Citation: BMC Microbiology 2018 18:155

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  36. Content type: Research article

    The effects of gut microbiota on human traits are expected to be small to moderate and adding the complexity of the human diseases, microbiome research demands big sample sizes. Fecal samples for such studies ...

    Authors: Joanna W. Szopinska, Raphaële Gresse, Saskia van der Marel, Jos Boekhorst, Sabina Lukovac, Iris van Swam, Barbara Franke, Harro Timmerman, Clara Belzer and Alejandro Arias Vasquez

    Citation: BMC Microbiology 2018 18:110

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  37. Content type: Research article

    Hypervirulent Klebsiella pneumoniae (hvKP) is emerging around the Asian-Pacific region and it is the major cause of the community-acquired pyogenic liver abscesses. Multidrug-resistant hypervirulent Klebsiella pn...

    Authors: Qiucheng Shi, Peng Lan, Danyan Huang, Xiaoting Hua, Yan Jiang, Jiancang Zhou and Yunsong Yu

    Citation: BMC Microbiology 2018 18:94

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  38. Content type: Research article

    Chronic Lung Allograft Dysfunction (CLAD) is the main cause of morbidity and mortality after the first year following lung transplantation (LTx). Risk factors of CLAD have been extensively studied, but the ass...

    Authors: Sarah Orfanos, Carine Gomez, Sophie Baron, Ritesh Akkisetty, Nadine Dufeu, Bérengère Coltey, Pascal Alexandre Thomas, Jean Marc Rolain and Martine Reynaud-Gaubert

    Citation: BMC Microbiology 2018 18:88

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  39. Content type: Research article

    Gold nanoparticles (AuNP) have several biochemical advantageous properties especially for a candidate of drug carrier. However, the non-conjugated AuNP has a higher rate of cellular uptake than the conjugated ...

    Authors: Sujittra Taratummarat, Naunpun Sangphech, Chau Tran Bao Vu, Tanapat Palaga, Thunnicha Ondee, Saowapha Surawut, Amornpun Sereemaspun, Patcharee Ritprajak and Asada Leelahavanichkul

    Citation: BMC Microbiology 2018 18:85

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  40. Content type: Research

    Sepsis refers to clinical presentations ranging from mild body dysfunction to multiple organ failure. These clinical symptoms result from a systemic inflammatory response to pathogenic or potentially pathogeni...

    Authors: Monica Martins Pereira Faria, Brent Warren Winston, Michael Gordon Surette and John Maynard Conly

    Citation: BMC Microbiology 2018 18:79

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  41. Content type: Research article

    Salmonella vaccination is one of the control measure that farmers can use to reduce bacterial shedding in their flocks. This study aimed to examine the efficacy of the Vaxsafe® ST (Strain STM-1) attenuated live v...

    Authors: Pardeep Sharma, Charles Caraguel, Margaret Sexton, Andrea McWhorter, Greg Underwood, Karen Holden and Kapil Chousalkar

    Citation: BMC Microbiology 2018 18:78

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  42. Content type: Research article

    Moraxella catarrhalis (M. catarrhalis) is an important bacterial pathogen. However, its antibiotic susceptibility patterns in different areas are difficult to compare because of the use of different methods and j...

    Authors: Wei Shi, Denian Wen, Changhui Chen, Lin Yuan, Wei Gao, Ping Tang, Xiaoping Cheng and Kaihu Yao

    Citation: BMC Microbiology 2018 18:77

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  43. Content type: Research article

    Shiga toxin producing E. coli (STEC) is an emerging zoonotic pathogen that can cause acute renal failure, especially in children. Clinical microbiology laboratories may fail to detect STEC and other diarrhoeic E....

    Authors: John Bosco Kalule, Karen H. Keddy and Mark P. Nicol

    Citation: BMC Microbiology 2018 18:55

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  44. Content type: Research article

    Identification and characterization of non-typeable Haemophilus influenzae (NTHi) with reduced susceptibility to β-lactam antibiotics due to mutations in penicillin binding protein 3 (PBP3) is a clinical challeng...

    Authors: John Thegerström, Erika Matuschek, Yu-Ching Su, Kristian Riesbeck and Fredrik Resman

    Citation: BMC Microbiology 2018 18:48

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  45. Content type: Research article

    Antimicrobial resistant Coagulase-negative Staphylococci (CoNS) have limited treatment options, rendered diseases untreatable and made hospitals to be reservoirs of the resistant strains. The aim of this study...

    Authors: Serawit Deyno, Sintayehu Fekadu and Sisay Seyfe

    Citation: BMC Microbiology 2018 18:43

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  46. Content type: Research article

    Carbapenemases-producing Enterobacteriaceae (CPE) are a worldwide public health emergency. In Mexico, reports of CPE are limited, particularly in the pediatric population. Here, we describe the clinical, epide...

    Authors: Alejandra Aquino-Andrade, Jocelin Merida-Vieyra, Eduardo Arias de la Garza, Patricia Arzate-Barbosa and Agustín De Colsa Ranero

    Citation: BMC Microbiology 2018 18:38

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  47. Content type: Research article

    During the past decades, Streptococcus dysgalactiae subspecies equisimilis (SDSE) has been increasingly recognized as an important human pathogen. Osteoarticular infections is one of the predominant disease manif...

    Authors: Oddvar Oppegaard, Haima Mylvaganam, Steinar Skrede and Bård Reiakvam Kittang

    Citation: BMC Microbiology 2018 18:17

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  48. Content type: Research article

    Two-thirds of the world’s population is thought to be infected by Helicobacter pylori. Although most people infected with H. pylori are asymptomatic, this pathogen is associated with several gastric pathologies i...

    Authors: Phattharaphon Wongphutorn, Chariya Chomvarin, Banchob Sripa, Wises Namwat and Kiatichai Faksri

    Citation: BMC Microbiology 2018 18:10

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  49. Content type: Research article

    Hypervirulent K. pneumoniae (hvKp) causes severe community acquired infections, predominantly in Asia. Though initially isolated from liver abscesses, they are now prevalent among invasive infections such as bact...

    Authors: Chaitra Shankar, Balaji Veeraraghavan, Laura Eve Buchnan Nabarro, Raji Ravi, Naveen Kumar Devanga Ragupathi and Priscilla Rupali

    Citation: BMC Microbiology 2018 18:6

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