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Fig. 5 | BMC Microbiology

Fig. 5

From: Promising biotherapeutic prospects of different probiotics and their derived postbiotic metabolites: in-vitro and histopathological investigation

Fig. 5

Inflammatory features in untreated and treated rat groups: (a) Sections in the rat paw tissue from group A showing almost no elicited inflammation. (b) Sections from group B showing significant edema and intense neutrophilic infiltrates (arrows) in the dermis, 5 h after the sub-plantar injection of carrageenan. (c) Sections from the indomethacin-treated group showing significant improvement in the inflammatory features compared to group B. (d, f) The probiotic culture-treated groups; (group D and group F) both showing a moderate anti-inflammatory response with a moderate number of inflammatory cellular infiltrates and edema seen in the deep dermis when compared to group B. (e, g) Sections from the probiotics CFS treated groups; Group E and group G showing mild improvement with dense inflammatory cells relative to the probiotic culture-treated groups (arrows), yet also showing a statistically significant difference (P < 0.001) when compared to the inflammation control group B

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