Table 1 Antimicrobial Susceptibility Testing of CRKP from HWW and Transconjugants
Antibiotics antimicrobial susceptibility (MICs(mg/L)) | W3A23 | W3A63 | W3A65 | W3A70 | W25A158 | W25A96 | W25A97 | W3A17 | W3A37 | W3A87 | W25A58 | Transconjugant (W25A96- blaKPC-2) | Transconjugant (W25A97- blaKPC-2) | Transconjugant (W25A158- blaKPC-2) | EC600 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ampicillin | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | 16/I |
Amoxicillin/Clavulanic Acid | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | \(\geqq\)32/R | 4/S |
Piperacillin/Tazobactam | \(\geqq\)128/R | \(\geqq\)128/R | 16/R | \(\geqq\)128/R | \(\geqq\)128/R | \(\geqq\)128/R | \(\geqq\)128/R | \(\geqq\)128/R | \(\geqq\)128/R | \(\geqq\)128/R | \(\geqq\)128/R | \(\geqq\)128/R | 64/R | \(\geqq\)128/R | \(\leqq\)4/S |
Cefazolin | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\leqq\)4/S |
Cefoxitin | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | 32/R | 32/R | 32/R | 8/S |
Ceftriaxone | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | 32/R | \(\geqq\)64/R | \(\leqq\)1/S |
Cefepime | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | 2/S | 2/S | 2/S | \(\leqq\)1/S |
Aztreonam | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64 R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\leqq\)1/S |
Ertapenem | 64/R | 64/R | 8/R | 64/R | 64/R | 128/R | 32/R | 64/R | 64/R | 64/R | 32/R | 16/R | 32/R | 4/R | 0.25/S |
Imipenem | 8/R | 16/R | 4/R | 16/R | 64/R | 64/R | 8/R | 8/R | 4/R | 8/R | 32/R | 8/R | 8/R | 8/R | 0.5/S |
meropenem | 32/R | 64/R | 64/R | 64/R | 8/R | 16/R | 8/R | 32/R | 16/R | 128/R | 64/R | 8/R | 8/R | 8/R | 0.25/R |
Amikacin | \(\geqq\)64/R | \(\leqq\)2/S | \(\geqq\)64/R | \(\leqq\)2/S | \(\geqq\)64/R | \(\geqq\)64/R | \(\geqq\)64/R | \(\leqq\)2/S | \(\leqq\)2/S | \(\leqq\)2/S | \(\geqq\)64/R | 4/S | \(\leqq\)2/S | 4/S | \(\leqq\)2/S |
Gentamicin | \(\geqq\)16/R | \(\leqq\)16/R | \(\geqq\)16/R | \(\geqq\)16/R | \(\geqq\)16/R | \(\geqq\)16/R | \(\geqq\)16/R | \(\leqq\)1/S | \(\leqq\)1/S | \(\leqq\)1/S | \(\geqq\)16/R | \(\leqq\)1/S | \(\leqq\)1/S | \(\leqq\)1/S | \(\leqq\)1/S |
Tobramycin | \(\geqq\)16/R | \(\geqq\)16 R | \(\geqq\)16/R | \(\geqq\)16/R | \(\geqq\)16/R | \(\geqq\)16/R | \(\geqq\)16/R | \(\leqq\)1/S | \(\leqq\)1/S | \(\geqq\)1/S | \(\geqq\)16/R | \(\leqq\)1/S | \(\leqq\)1/S | \(\leqq\)1/S | \(\leqq\)1/S |
Ciprofloxacin | \(\geqq\)4/R | 1/R | \(\geqq\)4/R | 1/R | \(\geqq\)4/R | \(\geqq\)4/R | 0.5/I | \(\geqq\)4/R | \(\geqq\)4/R | \(\geqq\)4/R | \(\geqq\)4/R | \(\leqq\)0.25/S | \(\leqq\)0.25/S | \(\leqq\)0.25/S | \(\leqq\)0.25/S |
Levofloxacin | \(\geqq\)8/R | 1/I | \(\geqq\)8/R | 1/I | \(\geqq\)8/R | \(\geqq\)8/R | 4/R | \(\geqq\)8/R | \(\geqq\)8/R | \(\geqq\)8/R | \(\geqq\)8/R | 0.5/S | 0.5/S | 0.5/S | 0.5/S |
Tigecycline | 16/R | 8/R | 4/I | 8/R | 8/R | 8/R | 8/R | 16/R | 8/R | 8/R | 8/R | 0.125/S | 0.125/S | 0.125/S | 0.125/S |
Nitrofurantoin | \(\geqq\)512/R | 256/R | \(\geqq\)512/R | 256/R | \(\geqq\)512/R | 64/I | 128/R | \(\geqq\)512/R | 256/R | \(\geqq\)512/R | 64/I | \(\geqq\)16/S | \(\leqq\)16/S | \(\leqq\)16/S | \(\leqq\)16/S |
Trimethoprim/Sulfamethoxazole | \(\geqq\)320/R | \(\geqq\)320/R | \(\geqq\)320/R | \(\geqq\)320/R | \(\leqq\)20/S | \(\geqq\)320/R | \(\geqq\)320/R | \(\geqq\)320/R | \(\geqq\)320/R | \(\geqq\)320/R | \(\geqq\)320/R | \(\geqq\)20/S | \(\leqq\)20/S | \(\leqq\)20/S | \(\leqq\)20/S |
Colistin | 2/I | 1/I | 2/I | 1/I | 1/I | 1/I | 1/I | 1/I | 1/I | 1/I | 64/R | 1/I | 1/I | 1/I | 0.25/I |