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Table 2 Resistance of erythromycin, telithromycin and cethromycin against S. aureus clinical isolates with erm genes or MLSB phenotypes

From: The antimicrobial activity of cethromycin against Staphylococcus aureus and compared with erythromycin and telithromycin

erm or MLSB (No.)

Erythromycin resistance (MIC ≥ 8 mg/L)

Telithromycin resistance (MIC ≥ 4 mg/L)

P values*

Cethromycin resistance (MIC ≥ 4 mg/L)

P values#

MRSA

 ermA(56)

56 (100.0%)

32 (57.1%)

 

29 (51.8%)

 

 ermB(46)

46 (100.0%)

43 (93.5%)

< 0.001a

13 (28.3%)

0.016a

 ermC(14)

13 (92.9%)

12 (85.7%)

0.048b

3 (21.4%)

0.041b

 cMLSB (104)

103 (99.0%)

84 (80.8%)

0.025c

47 (45.2%)

< 0.001c

 iMLSB (17)

17 (100.0%)

9 (52.9%)

 

0 (0.0%)

 

MSSA

 ermA(9)

8 (88.9%)

1 (11.1%)

 

0 (0.0%)

 

 ermB (42)

42 (100.0%)

37 (88.1%)

< 0.001a

18 (42.9%)

0.019a

 ermC (72)

71 (98.6%)

54 (75.0%)

< 0.001b

27 (37.5%)

0.026b

 cMLSB (55)

54 (98.2%)

49 (89.1%)

0.002c

26 (47.3%)

0.036c

 iMLSB (69)

68 (98.6%)

45 (65.2%)

 

20 (29.0%)

 
  1. MLSB Macrolide-lincosamide-streptogramin B, cMLSB Constitutive MLSB; iMLSB, Inducible MLSB, MIC Minimum inhibitory concentration, MRSA Methicillin-resistant Staphylococcus aureus, MSSA Methicillin-sensitive Staphylococcus aureus, The data was reported as number (percentage, %) and was compared using the chi-square test or Fisher’s exact test
  2. *P values for telithromycin resistance group
  3. #P values for cethromycin resistance group
  4. aermB vs ermA
  5. bermC vs ermA
  6. ccMLSB vs iMLSB