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Fig. 6 | BMC Microbiology

Fig. 6

From: Media component bovine serum albumin facilitates the formation of mycobacterial biofilms in response to reductive stress

Fig. 6

Model depicting the formation of biofilm by mycobacteria. BSA in the culture medium possesses several disulfide bonds, which are reduced by adding DTT. With the reoxidation of these reduced bonds, aggregate formation occurs, which leads to the formation of microscopic niches for the bacterial cells to initiate biofilm formation. Notably, intracellular TRS is required for biofilm formation as β-mercaptoethanol does not induce biofilm formation. Mycobacteria utilize cellulose to bind to the substratum and form a dense biofilm at maturation

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