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Table 2 PERMANOVA for microbial taxa, functional gene and metabolic pathways

From: Resilience and stability of the CF- intestinal and respiratory microbiome during nutritional and exercise intervention

  

Microbial taxa

Functional genes

Metabolic pathways

Parameter

DF

F

R2

FDR

F

R2

FDR

F

R2

FDR

Sputum

Severity

1

6.5

0.08

0.0030**

4.3

0.05

0.0300*

3.6

0.05

0.0660

Dominant taxa

3

15.6

0.55

0.0030**

15.2

0.56

0.0060**

9.8

0.45

0.0060**

Sex

1

2.2

0.03

0.1080

2.8

0.03

0.0920

3.4

0.05

0.0660

Age

1

1.2

0.01

0.3276

1.3

0.02

0.3108

1.2

0.02

0.3516

Visit

2

0.7

0.02

0.7540

0.4

0.01

0.9040

0.3

0.01

0.9270

BMI

1

1.8

0.02

0.1980

2.4

0.03

0.1170

2.6

0.04

0.0825

Residuals

24

-

0.29

-

-

0.30

-

-

0.37

-

Total

33

-

1.00

-

-

1.00

-

-

1.00

-

Stool

Severity

1

3.5

0.07

0.0020**

1.4

0.03

0.5000

1.0

0.03

0.6980

Dominant taxa

9

1.8

0.32

0.0020**

1.4

0.30

0.5000

1.4

0.31

0.5070

Sex

1

2.7

0.05

0.0020**

0.4

0.01

0.8712

0.5

0.01

0.7752

Age

1

1.3

0.03

0.1848

0.5

0.01

0.8712

0.5

0.01

0.7752

Visit

2

0.6

0.02

0.9990

0.3

0.02

0.9430

0.2

0.01

0.9820

BMI

1

1.9

0.04

0.0090**

2.9

0.07

0.3720

2.7

0.07

0.9820

Residuals

23

-

0.46

-

-

0.56

-

-

0.56

-

Total

38

-

1.00

-

-

1.00

-

-

1.00

-

  1. Displayed are PERMANOVA results on microbial taxa, functional gene and metabolic pathways composition in CF- sputum and stool samples in relation to disease severity, dominant taxa, sex, age, BMI and visit along the study. DF = degrees of freedom; F = F value by permutation and stratified by patient, p-values based on 999 permutations, FDR-corrected
  2. –-
  3. Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘’ 1
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BMC Microbiology

ISSN: 1471-2180

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