Human liver microbiota modeling strategy at the early onset of fibrosis

BMC Microbiology

Table 4 Identification of clusters of cohort-independent 16S rRNA gene associated with the different low scores of fibrosis using corrected t-test

Family	Genus	Significance	P-value	CSS mean (F0,F1)
sPLSDA
Burkholderiaceae	Ralstonia	F0 VS F1	0.001	1.32/4.19
Xanthobacteraceae	Bradyrhizobium	F0 VS F1	0.001	1.13/5.09
Enterobacteriaceae	Multi-affiliation	F0 VS F1	0.001	1.01/4.66
Pseudomonadaceae	Pseudomonas	F0 VS F1	0.001	0.44/4.2
Enterobacteriaceae	Kluyvera	F0 VS F1	0.005	1.34/4.79
Xanthomonadaceae	Stenotrophomonas	F0 VS F1	0.0005	3.92/7.54
Enterobacteriaceae	Multi-affiliation	F0 VS F1	0.01	1.08/5.54
Pseudomonadaceae	Pseudomonas	F0 VS F1	0.02	1.47/5.53
Corynebacteriaceae	Corynebacterium 1	F0 VS F1	0.05	1.07/0.20
Flavobacteriaceae	Flavobacterium	F0 VS F1	0.001	8.84/3.68
Fair-tree
Pseudomonadaceae	Pseudomonas	F0 VS F1	0.004	1.13/5.09
Enterobacteriaceae	Multi-affiliation	F0 VS F1	0.004	0.44/4.2
Xanthobacteraceae	Bradyrhizobium	F0 VS F1	0.003	3.92/7.54
Xanthomonadaceae	Stenotrophomonas	F0 VS F1	0.05	1.08/5.54
Fair Random Forest
Xanthomonadaceae	Stenotrophomonas	F0 VS F1	0.007	1.01/4.66
Enterobacteriaceae	Multi-affiliation	F0 VS F1	0.004	1.34/4.79
Enterobacteriaceae	Multi-affiliation	F0 VS F1	0.004	1.08/5.54
Enterobacteriaceae	Kosakonia	F0 VS F1	0.01	0.44/2.07
Enterobacteriaceae	Kluyvera	F0 VS F1	0.0007	0.88/2.67
Fair l1_spectral clustering
Pseudomonadaceae	Pseudomonas	F0 VS F1	0.01	0.44/4.2
Xanthobacteraceae	Bradyrhizobium	F0 VS F1	0.005	1.13/5.09
Enterobacteriaceae	Enterobacter	F0 VS F1	0.04	2.59/1.37
Burkholderiaceae	Ralstonia	F0 VS F1	0.03	1.32/4.19
Enterobacteriaceae	Multi-affiliation	F0 VS F1	0.01	1.01/4.66
Enterobacteriaceae	Kluyvera	F0 VS F1	0.04	0.88/2.67
Enterobacteriaceae	Multi-affiliation	F0 VS F1	0.003	1.08/5.54

ISSN: 1471-2180