Fig. 3

Protein-protein interaction using STRING database. The different nodes in the network represent the proteins while the network edges represent specific and meaningful protein-protein associations. The network is a scalable vector graphic [SVG]; interactive. The different node colors show the different level of interactions whereas the edge colors show their known, predicted and other interactions. The colored nodes show the query proteins and first shell of interactors, the white nodes represent second shell of interactors, empty nodes represent proteins of unknown 3D structure and filled nodes represent some 3D structure is known or predicted. The edges indicate both functional and physical protein associations whereas line color indicates the type of interaction evidence and the line thickness indicates the strength of data support. Among the known Interactions, Cyan are from curated databases and Purple are experimentally determined. In Predicted Interactions, green is from gene neighborhood analyses, red are gene fusions events, and blue are from gene co-occurrence. The other remaining interactions are; Olive = text-mining, black = co-expression, Navy Blue = protein homology